Oncotarget

Research Papers:

Aberrant expression of lncRNAs and mRNAs in patients with intracranial aneurysm

Wen Wang, Hao Li, Lanbing Yu, Zheng Zhao, Haoyuan Wang, Dong Zhang, Yan Zhang, Qing Lan, Jiangfei Wang and Jizong Zhao _

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Oncotarget. 2017; 8:2477-2484. https://doi.org/10.18632/oncotarget.13908

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Abstract

Wen Wang1,2,4,5,*, Hao Li1,4,5,*, Lanbing Yu1,4,5, Zheng Zhao3, Haoyuan Wang6, Dong Zhang1,4,5, Yan Zhang1,4,5, Qing Lan2, Jiangfei Wang1,4,5 and Jizong Zhao1,2,4,5

1 Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

2 Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China

3 Beijing Neurosurgical Institute, Capital Medical University, Beijing, China

4 China National Clinical Research Center for Neurological Diseases, Beijing, China

5 Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, China

6 Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China

* These authors have contributed equally to this work

Correspondence to:

Jizong Zhao, email:

Keywords: intracranial aneurysm; long non-coding RNA; microarray; gene ontology; pathway analysis

Received: September 26, 2016 Accepted: December 01, 2016 Published: December 11, 2016

Abstract

Intracranial aneurysm (IA) is pathological dilatations of the cerebral artery and rupture of IAs can cause subarachnoid hemorrhage, which has a high ratio of fatality and morbidity. However, the pathogenesis of IAs remains unknown. We performed long noncoding RNA (lncRNA) and messenger RNA (mRNA) expression profiles in IA tissues and superficial temporal arteries (STAs). A total of 4129 differentially expressed lncRNAs and 2926 differentially expressed mRNAs were obtained from the microarrays (P < 0.05). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses showed that up-regulated mRNAs were enriched in immune response, inflammatory response, regulation of immune response and lysosome, et al; while the down-regulated mRNAs were enriched in muscle contraction, smooth muscle contraction, cGMP-PKG signaling pathway and vascular smooth muscle contraction, et al. The lncRNA-mRNA co-expression networks were represented in immune response, inflammatory response, muscle contraction and vascular smooth muscle contraction. These findings may gain insight in the pathogenesis of IAs and provide clues to find key roles for IA patients.


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