Oncotarget

Research Papers:

Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations

Mengyun Wang, Qiaoxin Li, Chengyuan Gu, Yao Zhu, Yajun Yang, Jiucun Wang, Li Jin, Jing He, Dingwei Ye and Qingyi Wei _

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Oncotarget. 2017; 8:24362-24371. https://doi.org/10.18632/oncotarget.13848

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Abstract

Mengyun Wang1,8,*, Qiaoxin Li1,2,*, Chengyuan Gu3, Yao Zhu3, Yajun Yang4,5, Jiucun Wang4,5, Li Jin4,5, Jing He6, Dingwei Ye3, Qingyi Wei1,7,8

1Cancer Institute, Collaborative Innovation Center for Cancer Medicine, Fudan University Shanghai Cancer Center, Shanghai, China

2Department of Pathology, First Affiliated Hospital, Xinjiang Medical University, Urumqi, China

3Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China

4Ministry of Education Key Laboratory of Contemporary Anthropology, State Key Laboratory of Genetic Engineering, School of life Sciences, Fudan University, Shanghai, China

5Fudan-Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China

6Department of Hepatobiliary Oncology, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China

7Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA

8Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

*M. Wang and Q. Li contributed equally to this work and should be considered co-first authors

Correspondence to:

Dingwei Ye, email: [email protected]

Qingyi Wei, email: [email protected], [email protected]

Keywords: case-control study, prostate cancer, genetic susceptibility, nucleotide excision repair, polymorphism

Received: October 29, 2015    Accepted: November 21, 2016    Published: December 10, 2016

ABSTRACT

Genetic variants of nucleotide excision repair (NER) genes have been extensively investigated for their roles in the development of prostate cancer (PCa); however, the published results have been inconsistent. In a hospital-based case-control study of 1,004 PCa cases and 1,055 cancer-free controls, we genotyped eight potentially functional single nucleotide polymorphisms (SNPs) of NER genes (i.e., XPC, rs2228001 T>G and rs1870134 G>C; XPD, rs13181 T>G and rs238406 G>T; XPG, rs1047768 T>C, rs751402 C>T, and rs17655 G>C; and XPF, rs2276464 G>C) and assessed their associations with risk of PCa by using logistic regression analysis. Among these eight SNPs investigated, only XPC rs1870134 CG/CC variant genotypes were associated with a decreased risk of prostate cancer under a dominant genetic model (adjusted odds ratio [OR] = 0.77, 95% confidence interval [CI] = 0.64–1.91, P = 0.003). Phenotype-genotype analysis also suggested that the XPC rs1870134 CG/CC variant genotypes were associated with significantly decreased expression levels of XPC mRNA in a mix population of different ethnicities. These findings suggested that XPC SNPs may contribute to risk of PCa in Eastern Chinese men.


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