Research Papers:
Prognostic significance of pretreatment elevated platelet count in patients with colorectal cancer: a meta-analysis
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Abstract
Yu Long1, Ting Wang1,2, Qian Gao3, Chengya Zhou1
1Department of Medical Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
2Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
3Oncology Department, Du Jiang Yan Medical Center, Chengdu, Sichuan, China
Correspondence to:
Ting Wang, email: [email protected]
Keywords: colorectal cancer, platelet, thrombocytosis, prognosis, meta-analysis
Received: October 05, 2016 Accepted: October 24, 2016 Published: November 09, 2016
ABSTRACT
Background: The prognostic effect of pretreatment elevated platelet count remains controversial in colorectal cancer patients. We conducted this meta-analysis to evaluate the prognostic impact of it in these patients.
Methods: PubMed, EMBASE and Cochrane Library were searched and studies on the prognostic significance of pretreatment elevated platelet count in colorectal patients were identified. We performed the meta-analysis, using overall survival and disease-free survival as outcomes and presenting data with hazard ratio and its 95% confidence interval. Heterogeneity among studies and publication bias were also evaluated.
Results: Thirty studies were included in the meta-analysis. Compared with normal platelet count, pretreatment elevated platelet count was associated with poorer overall survival (Hazard ratio = 1.837, 95% confidence interval, 1.497 to 2.255, p = 0.000) and poorer disease-free survival (Hazard ratio = 1.635, 95% confidence interval, 1.237 to 2.160, p = 0.001) in patients with colorectal cancer. In subgroup analyses, pretreatment elevated platelet count was also associated with poorer overall survival and disease-free survival in most subgroups.
Conclusion: Pretreatment elevated platelet count was an independent prognostic factor of overall survival and disease-free survival in colorectal cancer patients. Large-scale prospective studies and a validation study are warranted.
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