Knockdown of long non-coding RNA CCAT2 suppressed proliferation and migration of glioma cells

Hua Guo; Qing Yang; Guowen Hu; Pei Zhang; Wei Kuang; Xingen Zhu; Lei Wu

doi:10.18632/oncotarget.13242

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Knockdown of long non-coding RNA CCAT2 suppressed proliferation and migration of glioma cells

Hua Guo _, Qing Yang, Guowen Hu, Pei Zhang, Wei Kuang, Xingen Zhu and Lei Wu

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2016; 7:81806-81814. https://doi.org/10.18632/oncotarget.13242

Metrics: PDF 2365 views | HTML 3314 views | ?

Abstract

Hua Guo1,*, Guowen Hu1,*, Qing Yang2, Pei Zhang1, Wei Kuang1, Xingen Zhu1, Lei Wu1

1Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China

2Department of Respiratory Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China

*These authors have contributed equally to this work

Correspondence to:

Lei Wu, email: [email protected]

Xingen Zhu, email: [email protected]

Keywords: qRT-PCR, quantitative real-time PCR; lncRNA, long non-coding RNA (lncRNAs); CCK-8, cell counting kit-8

Received: September 14, 2016 Accepted: October 14, 2016 Published: November 09, 2016

ABSTRACT

Long non-coding RNA colon cancer-associated transcript 2 (CCAT2) is commonly investigated in a number of cancers. However, little is known of its expression and biological function in glioma biology. In the current study, we used quantitative real-time PCR (qRT-PCR) to determine the expression of CCAT2 in glioma tissues. We found that expression of CCAT2 was up-regulated in glioma tissues and significantly correlated with the advanced tumor stage (III/IV). Functional assays in vitro and in vivo demonstrated that knockdown of CCAT2 could inhibit proliferation, cell cycle progression and migration of glioma cells. Further analysis indicated the effect of CCAT2 knockdown on glioma cell phenotype through inhibiting Wnt/β-catenin signal pathway activity. Thus, our study provides evidence that CCAT2 may function as a potential biomarker for glioma.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 13242

Publication Alerts

Post-Publication Promotion

Research Papers:

Knockdown of long non-coding RNA CCAT2 suppressed proliferation and migration of glioma cells

Abstract