Oncotarget

Research Papers:

IL-10 and PRKDC polymorphisms are associated with glioma patient survival

Mingjun Hu, Jieli Du, Lihong Cui, Tingqin Huang, Xiaoye Guo, Yonglin Zhao, Xudong Ma, Tianbo Jin, Gang Li and Jinning Song _

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Oncotarget. 2016; 7:80680-80687. https://doi.org/10.18632/oncotarget.13028

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Abstract

Mingjun Hu1,2, Jieli Du3,4, Lihong Cui5, Tingqin Huang1, Xiaoye Guo1, Yonglin Zhao1, Xudong Ma1, Tianbo Jin6, Gang Li7, Jinning Song1

1Department of Neurosurgery, First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061, China

2Department of Neurosurgery, Xi’an First Hospital, Xi’an 710002, China

3Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010050, China

4Department of Orthopedics and Traumatology, The 2nd Affiliated Hospital of Inner Mongolia University, Hohhot, Inner Mongolia, 010030, China

5Department of Neurology, Shangluo Central Hospital, Shangluo 726000, China

6Key Laboratory of Resource Biology and Biotechnology in Western China, Northwest University, Ministry of Education, School of Life Sciences, Northwest University, Xi’an 710069, China

7Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an 710038, China

Correspondence to:

Jinning Song, email: [email protected]

Keywords: IL-10, PRKDC, biomarker, glioma, polymorphism

Received: August 23, 2016     Accepted: October 24, 2016     Published: November 02, 2016

ABSTRACT

Interleukin-10 (IL-10) and DNA repair gene PRKDC mutations are implicated in the development of multiple human cancers, including glioma. We investigated associations between IL-10 and PRKDC gene polymorphisms and prognosis in low- and high-grade glioma patients. We analyzed the associations of one IL-10 and one PRKDC single nucleotide polymorphism with patient clinical factors in 481 glioma patients using Cox proportional hazard models and Kaplan-Meier curves. We also assessed associations between patient clinical characteristics and prognosis. Our data showed that the extent of tumor resection (gross-total resection) and application of chemotherapy were associated with improved patient outcomes in all glioma cases. Additionally, univariate (Log-rank p = 0.019) and multivariate Cox regression analyses (p = 0.022) showed that the IL-10 rs1800871 C/T genotype correlates with improved overall survival in cases of low-grade glioma, whereas the PRKDC rs7003908 C/C genotype correlated with reduced overall and progression-free survival in high-grade glioma patients in univariate (Log-rank p = 0.000 and p = 0.000, respectively) and multivariate Cox regression analyses (p = 0.001; p = 0.002, respectively). These results suggest that IL-10 rs1800871 and PRKDC rs7003908 may be useful biomarkers for predicting glioma patient outcome. Further functional studies are needed to evaluate the mechanisms by which these polymorphisms affect glioma progression.


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