Matrix metalloproteinase-13 refines pathological staging of precancerous colorectal lesions

Anna-Katharina Wernicke; Yuri Churin; Diana Sheridan; Anita Windhorst; Annette Tschuschner; Stefan Gattenlöhner; Martin Roderfeld; Elke Roeb

doi:10.18632/oncotarget.12429

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Research Papers:

Matrix metalloproteinase-13 refines pathological staging of precancerous colorectal lesions

Anna-Katharina Wernicke, Yuri Churin, Diana Sheridan, Anita Windhorst, Annette Tschuschner, Stefan Gattenlöhner, Martin Roderfeld and Elke Roeb _

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Oncotarget. 2016; 7:73552-73557. https://doi.org/10.18632/oncotarget.12429

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Abstract

Anna-Katharina Wernicke1, Yuri Churin1, Diana Sheridan2, Anita Windhorst3, Annette Tschuschner1, Stefan Gattenlöhner2, Martin Roderfeld1, Elke Roeb1

1Department of Gastroenterology, Justus-Liebig-University, Giessen, Germany

2Department of Pathology, Justus-Liebig-University, Giessen, Germany

3Institute for Medical Informatics, Justus-Liebig-University, Giessen, Germany

Correspondence to:

Elke Roeb, email: [email protected]

Keywords: MMP, neoplasia, colon cancer, adenoma, immunoreactive scoring

Received: May 30, 2016 Accepted: September 15, 2016 Published: October 04, 2016

ABSTRACT

An exact classification of precancerous stages of colorectal polyps might improve therapy and patients´ outcome. Here we investigate the association between grade of dysplasia and Matrix metalloproteinase-13 (MMP-13) expression in 137 biopsies from patients with cancerous and non-cancerous colorectal adenomas. A reproducible staining procedure for histologic MMP-13 analysis in routinely fixed colorectal biopsy specimens has been established. A newly adopted immunoreactive scoring system for MMP-13 was demonstrated as reliable readout.

The strength of the association between pathologic stage and immunoreactive MMP-13 scoring emphasizes its eligibility for diagnosis in precancerous colorectal lesions.

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Research Papers:

Matrix metalloproteinase-13 refines pathological staging of precancerous colorectal lesions

Abstract