Research Papers:
Thermo-sensitive composite hydrogels based on poloxamer 407 and alginate and their therapeutic effect in embolization in rabbit VX2 liver tumors
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Abstract
Lili Huang1, Ming Shen1, Rongxin Li1, Xiangyu Zhang1, Ying Sun1, Pei Gao1, Hao Fu1, Hongqiang Liu2, Yang He2, Yuqing Du3, Jun Cao2, Yourong Duan1
1State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Interventional Oncology, Dahua Hospital, Xuhui District, Shanghai, China
3Department of Interventional Radiology, Shanghai Pudong New District Punan Hospital, Shanghai, China
Correspondence to:
Yourong Duan, email: [email protected]
Jun Cao, email: [email protected]
Yuqing Du, email: [email protected]
Keywords: thermo-sensitive composite hydrogels, poloxamer 407, sodium alginate, sol-gel transition, transarterial embolization
Received: April 12, 2016 Accepted: August 25, 2016 Published: September 1, 2016
ABSTRACT
Interventional embolization therapy is an effective, most widely used method for inoperable liver tumors. Blood-vessel-embolic agents were essential in transarterial embolization (TAE). In this work, thermo-sensitive composite hydrogels based on poloxamer 407, sodium alginate, hydroxymethyl cellulose and iodixanol (PSHI), together with Ca2+ (PSHI-Ca2+) were prepared as liquid embolic agents for TAE therapy to liver cancer. With increasing temperature, PSHI exhibited two phase states: a flowing sol and a shrunken gel. Rheology tests showed good fluidity and excellent viscoelastic behavior with a gelation temperature (GT) of 26.5°C. The studies of erosion indicated that PSHI had calcium ion-related erosion characteristics and showed a slow erosion rate in an aqueous environment. When incubated with L929 cells, the thermo-sensitive composite hydrogels had low cytotoxicity in vitro. The results of analyzing the digital subtraction angiography and computed tomography images obtained from in vitro and in vivo assays indicated a good embolic effect in the renal arteries of normal rabbits. Angiography and histological studies on VX2 tumor-bearing rabbits indicated that PSHI-Ca2+ successfully occluded the tumors, including the peripheral vessels. In conclusion, PSHI-Ca2+ was a promising embolic agent for transarterial embolization therapy.
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