RhoGDIα suppresses self-renewal and tumorigenesis of glioma stem cells

Fan Wu; Peishan Hu; Dengke Li; Yan Hu; Yingjiao Qi; Bin Yin; Tao Jiang; Jiangang Yuan; Wei Han; Xiaozhong Peng

doi:10.18632/oncotarget.11423

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

RhoGDIα suppresses self-renewal and tumorigenesis of glioma stem cells

Fan Wu, Peishan Hu, Dengke Li, Yan Hu, Yingjiao Qi, Bin Yin, Tao Jiang, Jiangang Yuan, Wei Han and Xiaozhong Peng _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2016; 7:61619-61629. https://doi.org/10.18632/oncotarget.11423

Metrics: PDF 2074 views | HTML 2538 views | ?

Abstract

Fan Wu1, Peishan Hu1, Dengke Li1, Yan Hu1, Yingjiao Qi1, Bin Yin1, Tao Jiang2, Jiangang Yuan1, Wei Han1, Xiaozhong Peng1

1State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China

2Department of Neurosurgery, Beijing Tiantan Hospital, Beijing 100050, China

Correspondence to:

Xiaozhong Peng, email: [email protected]

Wei Han, email: [email protected]

Keywords: GSCs, RhoGDIα, self-renewal, ROCK1, Oct4

Received: October 07, 2015 Accepted: August 08, 2016 Published: August 19, 2016

ABSTRACT

Glioma stem cells (GSCs) are a subset of tumor cells that drive glioma initiation and progression. The molecular mechanisms underlying the maintenance of GSCs are still poorly understood. Here we investigated the role of Rho GDP dissociation inhibitor α (RhoGDIα) in GSCs. RhoGDIα was down-regulated in glioma stem cells. Over-expression of RhoGDIα suppressed the self-renewal and tumorigenesis of GSCs. Further data showed that RhoGDIα inhibited the transcription activity of stem cell marker Oct4. Moreover, inactivation of ROCK1, a downstream effector of RhoGDIα, also decreased the self-renewal and Oct4 transcription activity, and rescued the effects caused by RhoGDIα knockdown. Our results indicate that RhoGDIα is involved in the maintenance of GSCs.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 11423

Publication Alerts

Post-Publication Promotion

Publication Discount

Research Papers:

RhoGDIα suppresses self-renewal and tumorigenesis of glioma stem cells

Abstract