Oncotarget

Research Papers: Gerotarget (Focus on Aging):

Do human B-lymphocytes avoid aging until 60 years?

Andrea Knight, Pavel Nemec, Sona Bretzova, Lucie Valkova, Marketa Kolmanova, Renata Vytopilova, Marek Havelka, Pavla Vsianska, Lucie Rihova, Marta Krejci and Martin Piskacek _

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Oncotarget. 2016; 7:42873-42880. https://doi.org/10.18632/oncotarget.10146

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Abstract

Andrea Knight1,2,*, Pavel Nemec1, Sona Bretzova1,5, Lucie Valkova1,5, Marketa Kolmanova1,5, Renata Vytopilova1,5, Marek Havelka1,5, Pavla Vsianska3, Lucie Rihova3, Marta Krejci4 and Martin Piskacek1,5,*

1 Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic

2 Gamma-Delta T Cell Laboratory, University Hospital Brno, Brno, Czech Republic

3 Department of Clinical Haematology, University Hospital Brno, Brno, Czech Republic

4 Department of Internal Medicine, Haematology and Oncology, University Hospital Brno, Brno, Czech Republic

5 Laboratory of Cancer Biology and Genetics, University Hospital Brno, Brno, Czech Republic

* These authors have contributed equally to the study and should be considered as joint senior authors

Correspondence to:

Martin Piskacek, email:

Keywords: aging, B cell, naive B cells, IL7R, GEP, Gerotarget

Received: March 25, 2016 Accepted: June 03, 2016 Published: June 17, 2016

Abstract

Broad changes in human innate and adaptive immunity are associated with advanced age. The age-related alteration of gene expression was reported for both T and B lymphocytes. We analysed the genome-wide expression profiles (n=20) of naive and whole B cell populations from young and early aged healthy donors under 60 years. We revealed large homogeneity of all analysed genome-wide expression profiles but did not identified any significant gene deregulation between young (30-45 years) and early aged healthy donors (50-60 years). We argue that B cells avoid the aging program on molecular level until 60 years of age. Our results demonstrate the potential of hematopoietic stem cells to generate uncompromised lymphocytes in early elderly. These are very encouraging findings for the general health and the immunity maintenance would not need any intervention to naive B cells. Rather, a suitable immune stimulation in healthy body environment warrants further research into aging of older elderly.


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