Oncotarget

January 30, 2018

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About The Cover

The cover for issue 8 of Oncotarget features Figure 4D, "Representative images of mAb414 staining in DMSO (diffused) or BI (on chromosomes)–treated cells," from de Castro, et al.

Table of Contents

Research Papers: Gerotarget (Focus on Aging)

Possible mechanism underlying the association between height and vascular remodeling in elderly Japanese men

Possible mechanism underlying the association between height and vascular remodeling in elderly Japanese men

https://doi.org/10.18632/oncotarget.23660

Yuji Shimizu, Shimpei Sato, Jun Koyamatsu, Hirotomo Yamanashi, Mako Nagayoshi, Koichiro Kadota, Shin-Ya Kawashiri,  and Takahiro Maeda
7749-7757
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Research Papers: Pathology

Fabry disease and multiple sclerosis misdiagnosis: the role of family history and neurological signs

Fabry disease and multiple sclerosis misdiagnosis: the role of family history and neurological signs

https://doi.org/10.18632/oncotarget.23970

Paolo Colomba, Carmela Zizzo, Riccardo Alessandro, Giuseppe Cammarata, Simone Scalia, Antonello Giordano, Maurizio Pieroni, Luigi Sicurella, Luisa Amico, Alessandro Burlina,  and Giovanni Duro
7758-7762
Abstract  |  PDF  |  HTML  |  How to cite

Research Papers: Chromosome

CDK1 and PLK1 coordinate the disassembly and reassembly of the nuclear envelope in vertebrate mitosis

CDK1 and PLK1 coordinate the disassembly and reassembly of the nuclear envelope in vertebrate mitosis

https://doi.org/10.18632/oncotarget.23666

Ines J de Castro, Raquel Sales Gil, Lorena Ligammari, Maria Laura Di Giacinto,  and Paola Vagnarelli
7763-7773
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Research Papers

Temozolomide combined with irinotecan regresses a cisplatinum-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) precision-oncology mouse model

Temozolomide combined with irinotecan regresses a cisplatinum-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) precision-oncology mouse model

https://doi.org/10.18632/oncotarget.22892

Kentaro Igarashi, Kei Kawaguchi, Tasuku Kiyuna, Kentaro Miyake, Masuyo Miyake, Yunfeng Li, Scott D. Nelson, Sarah M. Dry, Arun S. Singh, Irmina A. Elliott, Tara A. Russell, Mark A. Eckardt, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Hiroyuki Tsuchiya, Fritz C. Eilber,  and Robert M. Hoffman
7774-7781
Abstract  |  PDF  |  HTML  |  How to cite

T-lymphokine-activated killer cell-originated protein kinase (TOPK) as a prognostic factor and a potential therapeutic target in glioma

T-lymphokine-activated killer cell-originated protein kinase (TOPK) as a prognostic factor and a potential therapeutic target in glioma

https://doi.org/10.18632/oncotarget.23674

Chuntao Quan, Juanjuan Xiao, Qiuhong Duan, Ping Yuan, Peipei Xue, Hui Lu, Meng Yan, Dongsheng Guo, Sanpeng Xu, Xiaohui Zhang, Xuan Lin, Yong Wang, Soner Dogan, Jianmin Zhang, Feng Zhu, Changshu Ke,  and Lin Liu
7782-7795
Abstract  |  PDF  |  HTML  |  How to cite

Use of deep neural network ensembles to identify embryonic-fetal transition markers: repression of COX7A1 in embryonic and cancer cells

Use of deep neural network ensembles to identify embryonic-fetal transition markers: repression of COX7A1 in embryonic and cancer cells

https://doi.org/10.18632/oncotarget.23748

Michael D. West, Ivan Labat, Hal Sternberg, Dana Larocca, Igor Nasonkin, Karen B. Chapman, Ratnesh Singh, Eugene Makarev, Alex Aliper, Andrey Kazennov, Andrey Alekseenko, Nikolai Shuvalov, Evgenia Cheskidova, Aleksandr Alekseev, Artem Artemov, Evgeny Putin, Polina Mamoshina, Nikita Pryanichnikov, Jacob Larocca, Karen Copeland, Evgeny Izumchenko, Mikhail Korzinkin,  and Alex Zhavoronkov
7796-7811
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Uncovering genetic and non-genetic biomarkers specific for exudative age-related macular degeneration: significant association of twelve variants

Uncovering genetic and non-genetic biomarkers specific for exudative age-related macular degeneration: significant association of twelve variants

https://doi.org/10.18632/oncotarget.23241

Raffaella Cascella, Claudia Strafella, Giuliana Longo, Michele Ragazzo, Laura Manzo, Cecilia De Felici, Valeria Errichiello, Valerio Caputo, Francesco Viola, Chiara Maria Eandi, Giovanni Staurenghi, Andrea Cusumano, Silvestro Mauriello, Luigi Tonino Marsella, Cinzia Ciccacci, Paola Borgiani, Federica Sangiuolo, Giuseppe Novelli, Federico Ricci,  and Emiliano Giardina
7812-7821
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Ependymomas overexpress chemoresistance and DNA repair-related proteins

Ependymomas overexpress chemoresistance and DNA repair-related proteins

https://doi.org/10.18632/oncotarget.23288

Sherise D. Ferguson, Shouhao Zhou, Joanne Xiu, Yuuri Hashimoto, Nader Sanai, Lyndon Kim, Santosh Kesari, John de Groot, David Spetzler,  and Amy B. Heimberger
7822-7831
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Rapid detection of BRCA1/2 recurrent mutations in Chinese breast and ovarian cancer patients with multiplex SNaPshot genotyping panels

Rapid detection of BRCA1/2 recurrent mutations in Chinese breast and ovarian cancer patients with multiplex SNaPshot genotyping panels

https://doi.org/10.18632/oncotarget.23471

Ava Kwong, John C.W. Ho, Vivian Y. Shin, Allison W. Kurian, Edmund Tai, Laura J. Esserman, Jeffery N. Weitzel, Po-Han Lin, Michael Field, Susan M. Domchek, Jessica Lo, Hextan Y.S. Ngan, Edmond S.K. Ma, Tsun L. Chan,  and James M. Ford
7832-7843
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

The evolutionary pattern of mutations in glioblastoma reveals therapy-mediated selection

The evolutionary pattern of mutations in glioblastoma reveals therapy-mediated selection

https://doi.org/10.18632/oncotarget.23541

Andrea M. Muscat, Nicholas C. Wong, Katharine J. Drummond, Elizabeth M. Algar, Mustafa Khasraw, Roel Verhaak, Kathryn Field, Mark A. Rosenthal,  and David M. Ashley
7844-7858
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

DPYD and UGT1A1 genotyping to predict adverse events during first-line FOLFIRI or FOLFOXIRI plus bevacizumab in metastatic colorectal cancer

DPYD and UGT1A1 genotyping to predict adverse events during first-line FOLFIRI or FOLFOXIRI plus bevacizumab in metastatic colorectal cancer

https://doi.org/10.18632/oncotarget.23559

Chiara Cremolini, Marzia Del Re, Carlotta Antoniotti, Sara Lonardi, Francesca Bergamo, Fotios Loupakis, Beatrice Borelli, Federica Marmorino, Valentina Citi, Enrico Cortesi, Roberto Moretto, Monica Ronzoni, Gianluca Tomasello, Alberto Zaniboni, Patrizia Racca, Angela Buonadonna, Giacomo Allegrini, Vincenzo Ricci, Samantha Di Donato, Vittorina Zagonel, Luca Boni, Alfredo Falcone,  and Romano Danesi
7859-7866
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Genetic and metabolic comparison of orthotopic and heterotopic patient-derived pancreatic-cancer xenografts to the original patient tumors

Genetic and metabolic comparison of orthotopic and heterotopic patient-derived pancreatic-cancer xenografts to the original patient tumors

https://doi.org/10.18632/oncotarget.23567

Eunsung Jun, Seung-Mo Hong, Hyun Ju Yoo, Moon-Bo Kim, Ji Sun Won, Soyeon An, In Kyong Shim, Suhwan Chang, Robert M. Hoffman,  and Song-Cheol Kim
7867-7881
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Molecular imaging of Toll-like receptor 4 detects ischemia-reperfusion injury during intussusception

Molecular imaging of Toll-like receptor 4 detects ischemia-reperfusion injury during intussusception

https://doi.org/10.18632/oncotarget.23609

Zhang-Chun Hu, Ya-Lan Tan, Shun-Gen Huang, Peng Pan, Xiao-Bo Liu, Jian Wang,  and Wan-Liang Guo
7882-7890
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Increased high mobility group A 2 expression promotes transition of cervical intraepithelial neoplasm into cervical cancer

Increased high mobility group A 2 expression promotes transition of cervical intraepithelial neoplasm into cervical cancer

https://doi.org/10.18632/oncotarget.24080

Liming Wang, Hui Shen, Da Zhu, Bei Feng, Lan Yu, Xun Tian, Ci Ren, Chun Gao, Xiaomin Li, Ding Ma, Zheng Hu,  and Hui Wang
7891-7901
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Antitumor activity of HPA3P through RIPK3-dependent regulated necrotic cell death in colon cancer

Antitumor activity of HPA3P through RIPK3-dependent regulated necrotic cell death in colon cancer

https://doi.org/10.18632/oncotarget.24083

Eugene Cho, Jong-Kook Lee, Eunji Park, Chang Ho Seo, Tudor Luchian,  and Yoonkyung Park
7902-7917
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

C-Kit receptor and tryptase expressing mast cells correlate with angiogenesis in breast cancer patients

C-Kit receptor and tryptase expressing mast cells correlate with angiogenesis in breast cancer patients

https://doi.org/10.18632/oncotarget.23722

Ilaria Marech, Michele Ammendola, Christian Leporini, Rosa Patruno, Maria Luposella, Nicola Zizzo, Giuseppe Passantino, Rosario Sacco, Ammad Ahmad Farooqi, Valeria Zuccalà, Silvana Leo, Rosalba Dentamaro, Mariangela Porcelli, Pietro Gadaleta, Giovambattista De Sarro, Cosmo Damiano Gadaleta,  and Girolamo Ranieri
7918-7927
Abstract  |  PDF  |  HTML  |  How to cite

Network analysis of microRNAs, genes and their regulation in diffuse and follicular B-cell lymphomas

Network analysis of microRNAs, genes and their regulation in diffuse and follicular B-cell lymphomas

https://doi.org/10.18632/oncotarget.23974

Oshrat Hershkovitz-Rokah, Polina Geva, Mali Salmon-Divon, Ofer Shpilberg,  and Stella Liberman-Aronov
7928-7941
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

The effectiveness of PD-1 inhibitors in non-small cell lung cancer (NSCLC) patients of different ages

The effectiveness of PD-1 inhibitors in non-small cell lung cancer (NSCLC) patients of different ages

https://doi.org/10.18632/oncotarget.23678

Yingcheng Wu, Qianqian Ju, Bei Qian, Feng Zhang,  and Hui Shi
7942-7948
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Mutations in DNA repair genes are associated with increased neo-antigen load and activated T cell infiltration in lung adenocarcinoma

Mutations in DNA repair genes are associated with increased neo-antigen load and activated T cell infiltration in lung adenocarcinoma

https://doi.org/10.18632/oncotarget.23742

Young Kwang Chae, Jonathan F. Anker, Preeti Bais, Sandeep Namburi, Francis J. Giles,  and Jeffrey H. Chuang
7949-7960
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Clinical, prognostic, and therapeutic significance of heat shock protein 27 in bladder cancer

Clinical, prognostic, and therapeutic significance of heat shock protein 27 in bladder cancer

https://doi.org/10.18632/oncotarget.24091

Myung-Shin Lee, Jisu Lee, Suhyuk Lee, Seung-Min Yoo, Joo Heon Kim, Won Tae Kim, Wun-Jae Kim,  and Jinsung Park
7961-7974
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Intrahepatic cholangiocarcinoma in the setting of HBV-related cirrhosis: Differentiation with hepatocellular carcinoma by using Intravoxel incoherent motion diffusion-weighted MR imaging

Intrahepatic cholangiocarcinoma in the setting of HBV-related cirrhosis: Differentiation with hepatocellular carcinoma by using Intravoxel incoherent motion diffusion-weighted MR imaging

https://doi.org/10.18632/oncotarget.23807

Yi Wei, Feifei Gao, Dandan Zheng, Zixing Huang, Min Wang, Fubi Hu, Chenyang Chen, Ting Duan, Jie Chen, Likun Cao,  and Bin Song
7975-7983
Abstract  |  PDF  |  HTML  |  How to cite

A metabolomic study on early detection of steroid-induced avascular necrosis of the femoral head

A metabolomic study on early detection of steroid-induced avascular necrosis of the femoral head

https://doi.org/10.18632/oncotarget.24150

Xiangnan Ren, Wu Fan, Zixing Shao, Kaiyun Chen, Xuefeng Yu,  and Qionglin Liang
7984-7995
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

SIRT1 increases cardiomyocyte binucleation in the heart development

SIRT1 increases cardiomyocyte binucleation in the heart development

https://doi.org/10.18632/oncotarget.23847

Alexandra N Shin, Limin Han, Chiranjib Dasgupta, Lei Huang, Shumei Yang,  and Lubo Zhang
7996-8010
Abstract  |  PDF  |  HTML  |  How to cite

The “bad” cholesterol can predict abnormal apolipoprotein B levels in a large unselected outpatient cohort

The “bad” cholesterol can predict abnormal apolipoprotein B levels in a large unselected outpatient cohort

https://doi.org/10.18632/oncotarget.23759

Guo-Ming Zhang, Hemant Goyal, Gao-Ming Zhang, Xiao-Bo Ma,  and Ye-Ting Zhou
8011-8015
Abstract  |  PDF  |  HTML  |  How to cite

Identification of BAG3 target proteins in anaplastic thyroid cancer cells by proteomic analysis

Identification of BAG3 target proteins in anaplastic thyroid cancer cells by proteomic analysis

https://doi.org/10.18632/oncotarget.23858

Francesca Galdiero, Anna Maria Bello, Anna Spina, Anna Capiluongo, Sophie Liuu, Margot De Marco, Alessandra Rosati, Mario Capunzo, Maria Napolitano, Emilia Vuttariello, Mario Monaco, Daniela Califano, Maria Caterina Turco, Gennaro Chiappetta, Joëlle Vinh,  and Giovanni Chiappetta
8016-8026
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Inhibition of mTORC1/C2 signaling improves anti-leukemia efficacy of JAK/STAT blockade in CRLF2 rearranged and/or JAK driven Philadelphia chromosome–like acute B-cell lymphoblastic leukemia

Inhibition of mTORC1/C2 signaling improves anti-leukemia efficacy of JAK/STAT blockade in CRLF2 rearranged and/or JAK driven Philadelphia chromosome–like acute B-cell lymphoblastic leukemia

https://doi.org/10.18632/oncotarget.24261

Qi Zhang, Ce Shi, Lina Han, Nitin Jain, Kathryn G. Roberts, Helen Ma, Tianyu Cai, Antonio Cavazos, Yoko Tabe, Rodrigo O. Jacamo, Hong Mu, Yang Zhao, Jing Wang, Shuo-Chieh Wu, Fenglin Cao, Zhihong Zeng, Jin Zhou, Yingchang Mi, Elias J. Jabbour, Ross Levine, Sarah K. Tasian, Charles G. Mullighan, David M. Weinstock, David A. Fruman,  and Marina Konopleva
8027-8041
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

MMTV-NeuT/ATTAC mice: a new model for studying the stromal tumor microenvironment

MMTV-NeuT/ATTAC mice: a new model for studying the stromal tumor microenvironment

https://doi.org/10.18632/oncotarget.24233

Hongyan Yuan, Xiaoyi Wang, Jin Lu, Qiongsi Zhang, Irina Brandina, Ilya Alexandrov,  and Robert I. Glazer
8042-8053
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Ribavirin as a potential therapeutic for atypical teratoid/rhabdoid tumors

Ribavirin as a potential therapeutic for atypical teratoid/rhabdoid tumors

https://doi.org/10.18632/oncotarget.23883

Joshua Casaos, Sakibul Huq, Tarik Lott, Raphael Felder, John Choi, Noah Gorelick, Michael Peters, Yuanxuan Xia, Russell Maxwell, Tianna Zhao, Chenchen Ji, Thomas Simon, Julie Sesen, Sarah J. Scotland, Richard E. Kast, Jeffrey Rubens, Eric Raabe, Charles G. Eberhart, Eric M. Jackson, Henry Brem, Betty Tyler,  and Nicolas Skuli
8054-8067
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Biophysical studies and NMR structure of YAP2 WW domain - LATS1 PPxY motif complexes reveal the basis of their interaction

Biophysical studies and NMR structure of YAP2 WW domain - LATS1 PPxY motif complexes reveal the basis of their interaction

https://doi.org/10.18632/oncotarget.23909

Apoorva Verma, Fan Jing-Song, Megan L. Finch-Edmondson, Adrian Velazquez-Campoy, Shanker Balasegaran, J. Sivaraman Sivaraman,  and Jayaraman Sivaraman
8068-8080
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Meta-Analysis

The prognostic value of HPV combined p16 status in patients with anal squamous cell carcinoma: a meta-analysis

The prognostic value of HPV combined p16 status in patients with anal squamous cell carcinoma: a meta-analysis

https://doi.org/10.18632/oncotarget.23545

Guorui Sun, Xiaoyuan Dong, Xiaolong Tang, Hui Qu, Hao Zhang,  and Ensheng Zhao
8081-8088
Abstract  |  PDF  |  HTML  |  How to cite

Meta-analysis of the effects of ischemic postconditioning on structural pathology in ST-segment elevation acute myocardial infarction

Meta-analysis of the effects of ischemic postconditioning on structural pathology in ST-segment elevation acute myocardial infarction

https://doi.org/10.18632/oncotarget.23450

Baohui Lou, Yadong Cui, Haiyang Gao,  and Min Chen
8089-8099
Abstract  |  PDF  |  HTML  |  How to cite

Meta-analysis of the prognostic value of long non-coding RNA AFAP1-AS1 for cancer patients in China

Meta-analysis of the prognostic value of long non-coding RNA AFAP1-AS1 for cancer patients in China

https://doi.org/10.18632/oncotarget.23568

Rui-Hua Liu, Ming-Ying Wang, Ling-Yun Chen, Zhi-Jie Yin, Qian-Kun Ji, Yang-Yang Wang,  and Bao-Zhe Jin
8100-8110
Abstract  |  PDF  |  HTML  |  How to cite

Prognostic role of tumor-infiltrating CD57-positive lymphocytes in solid tumors: a meta-analysis

Prognostic role of tumor-infiltrating CD57-positive lymphocytes in solid tumors: a meta-analysis

https://doi.org/10.18632/oncotarget.23621

Guoming Hu,  and Shimin Wang
8111-8119
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Efficacy and safety of targeting VEGFR drugs in treatment for advanced or metastatic gastric cancer: a systemic review and meta-analysis

Efficacy and safety of targeting VEGFR drugs in treatment for advanced or metastatic gastric cancer: a systemic review and meta-analysis

https://doi.org/10.18632/oncotarget.23429

Duanrui Liu, Xiaoli Ma, Dongjie Xiao, Yanfei Jia,  and Yunshan Wang
8120-8132
Abstract  |  PDF  |  HTML  |  How to cite

Clinical Research Papers

Clinicopathological characteristics and survival outcomes in adenosquamous carcinoma of the lung: a population-based study from the SEER database

Clinicopathological characteristics and survival outcomes in adenosquamous carcinoma of the lung: a population-based study from the SEER database

https://doi.org/10.18632/oncotarget.23550

Jian Wang, Bi Lian, Ling Ye, Jie Hu,  and Yuanlin Song
8133-8146
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Prognostic role of the primary tumour site in patients with operable small intestine and gastrointestinal stromal tumours: a large population-based analysis

Prognostic role of the primary tumour site in patients with operable small intestine and gastrointestinal stromal tumours: a large population-based analysis

https://doi.org/10.18632/oncotarget.23692

Hua Ye, Hua Xin, Qi Zheng, Qijun Shen, Wenyu Dai, Feng Wu, Cheng Zheng,  and Ping Chen
8147-8154
Abstract  |  PDF  |  HTML  |  How to cite

A randomized phase II study of pelareorep and docetaxel or docetaxel alone in men with metastatic castration resistant prostate cancer: CCTG study IND 209

A randomized phase II study of pelareorep and docetaxel or docetaxel alone in men with metastatic castration resistant prostate cancer: CCTG study IND 209

https://doi.org/10.18632/oncotarget.24263

Bernhard Josef Eigl, Kim Chi, Dongsheng Tu, Sebastien J. Hotte, Eric Winquist, Christopher M. Booth, Christina Canil, Kylea Potvin, Richard Gregg, Scott North, Muhammad Zulfiqar, Susan Ellard, Joseph Dean Ruether, Lyly Le, Saranya A. Kakumanu, Mohammad Salim, Alison L. Allan, Harriet Feilotter, Ashley Theis,  and Lesley Seymour
8155-8164
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Reviews

FOXC1, the new player in the cancer sandbox

FOXC1, the new player in the cancer sandbox

https://doi.org/10.18632/oncotarget.22742

Fahed A. Elian, Elizabeth Yan,  and Michael A. Walter
8165-8178
Abstract  |  PDF  |  HTML  |  How to cite

microRNA involvement in the onset and progression of Barrett’s esophagus: a systematic review

microRNA involvement in the onset and progression of Barrett’s esophagus: a systematic review

https://doi.org/10.18632/oncotarget.24145

Reilly J. Clark, Michael P. Craig, Sangeeta Agrawal,  and Madhavi Kadakia
8179-8196
Abstract  |  PDF  |  HTML  |  How to cite

Case Reports

Complete response in a patient with liver metastases from breast cancer employing hepatic arterial infusion 5-fluorouracil based chemotherapy plus systemic nab-paclitaxel

Complete response in a patient with liver metastases from breast cancer employing hepatic arterial infusion 5-fluorouracil based chemotherapy plus systemic nab-paclitaxel

https://doi.org/10.18632/oncotarget.23793

Girolamo Ranieri, Ilaria Marech, Mariangela Porcelli, Francesco Giotta, Gennaro Palmiotti, Giuseppe Laricchia, Vito Fazio,  and Cosmo Damiano Gadaleta
8197-8203
Abstract  |  PDF  |  HTML  |  How to cite


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