Neurons from skin mimic brain holes

Neurotropic alphaviruses can propagate without capsid

α-synuclein and p53 functional interplay in physiopathological contexts

Approaching Alzheimer’s disease from a network level

Synthetic microneurotrophins in therapeutics of neurodegeneration

15-deoxy-Δ^12,14-prostaglandin J₂ in neurodegenerative diseases and cancers

Neurodevelopmental effects of anesthesia and environmental factors

Protecting the developing brain by 17β-estradiol

An insight of rapamycin against cadmium’s neurotoxicity

DJ1 at the interface between neuro-degeneration and cancer

The involvement of endoplasmic reticulum stress response in immune dysfunction of dendritic cells after severe thermal injury in mice

Loss of RUNX3 expression inhibits bone invasion of oral squamous cell carcinoma

Combined and individual tumor-specific expression of insulin-like growth factor-I receptor, insulin receptor and phospho-insulin-like growth factor-I receptor/insulin receptor in primary breast cancer: Implications for prognosis in different treatment groups

SORBS1 suppresses tumor metastasis and improves the sensitivity of cancer to chemotherapy drug

A novel histone deacetylase inhibitor, CKD5, has potent anti-cancer effects in glioblastoma

Anti-tumor activity of high-dose EGFR tyrosine kinase inhibitor and sequential docetaxel in wild type EGFR non-small cell lung cancer cell nude mouse xenografts

The impact of reproductive life on breast cancer risk in women with family history or BRCA mutation

Neuroinflammatory and cognitive consequences of combined radiation and immunotherapy in a novel preclinical model

Targeting the pro-angiogenic forms of VEGF or inhibiting their expression as anti-cancer strategies

Mesothelin-targeted immunotoxin RG7787 has synergistic anti-tumor activity when combined with taxanes

The matricellular protein CYR61 promotes breast cancer lung metastasis by facilitating tumor cell extravasation and suppressing anoikis

MutY-Homolog (MYH) inhibition reduces pancreatic cancer cell growth and increases chemosensitivity

Detection of 14-3-3 sigma (σ) promoter methylation as a noninvasive biomarker using blood samples for breast cancer diagnosis

S4S8-RPA phosphorylation as an indicator of cancer progression in oral squamous cell carcinomas

LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer

Reducing Smad3/ATF4 was essential for Sirt1 inhibiting ER stress-induced apoptosis in mice brown adipose tissue

Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress

Expression and clinical relevance of epithelial and mesenchymal markers in circulating tumor cells from colorectal cancer

Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice

Livin/BIRC7 expression as malignancy marker in adrenocortical tumors

Antagonizing functions of BARD1 and its alternatively spliced variant BARD1δ in telomere stability

Prognostic value and clinicopathological features of PD-1/PD-L1 expression with mismatch repair status and desmoplastic stroma in Chinese patients with pancreatic cancer

Vamorolone, a dissociative steroidal compound, reduces pro-inflammatory cytokine expression in glioma cells and increases activity and survival in a murine model of cortical tumor

Targeted delivery of CRISPR/Cas9 to prostate cancer by modified gRNA using a flexible aptamer-cationic liposome

Pharmacogenetic analysis of high-dose methotrexate treatment in children with osteosarcoma

Resveratrol-induced antinociception is involved in calcium channels and calcium/caffeine-sensitive pools

Overendocytosis of superparamagnetic iron oxide particles increases apoptosis and triggers autophagic cell death in human osteosarcoma cell under a spinning magnetic field

Gene expression profiling of tumor-initiating stem cells from mouse Krebs-2 carcinoma using a novel marker of poorly differentiated cells

Nuclear overexpression of the overexpressed in lung cancer 1 predicts worse prognosis in gastric adenocarcinoma

Long non-coding RNA AK058003, as a precursor of miR-15a, interacts with HuR to inhibit the expression of γ-synuclein in hepatocellular carcinoma cells

Identification of mTOR as a primary resistance factor of the IAP antagonist AT406 in hepatocellular carcinoma cells

V-ATPase inhibition increases cancer cell stiffness and blocks membrane related Ras signaling - a new option for HCC therapy

Chimeric antigen receptor-modified T Cells inhibit the growth and metastases of established tissue factor-positive tumors in NOG mice

Chrysophanic acid reduces testosterone-induced benign prostatic hyperplasia in rats by suppressing 5α-reductase and extracellular signal-regulated kinase

LMO2 promotes tumor cell invasion and metastasis in basal-type breast cancer by altering actin cytoskeleton remodeling

Identification of laryngeal cancer prognostic biomarkers using an inflammatory gene-related, competitive endogenous RNA network

HIF-1α induces the epithelial-mesenchymal transition in gastric cancer stem cells through the Snail pathway

Systematic evaluation of supervised classifiers for fecal microbiota-based prediction of colorectal cancer

EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect

A novel non-canonical Wnt signature for prostate cancer aggressiveness

Association between metformin use and mortality in patients with type 2 diabetes mellitus and localized resectable pancreatic cancer: a nationwide population-based study in korea

Down-regulation of 14q32-encoded miRNAs and tumor suppressor role for miR-654-3p in papillary thyroid cancer

The tumor microenvironment promotes cancer progression and cell migration

Androgen receptor transcriptionally regulates semaphorin 3C in a GATA2-dependent manner

Inhibition of long non-coding RNA UCA1 by CRISPR/Cas9 attenuated malignant phenotypes of bladder cancer

Histone deacetylase inhibitor SAHA mediates mast cell death and epigenetic silencing of constitutively active D816V KIT in systemic mastocytosis

Diagnostic accuracy of urine HE4 in patients with ovarian cancer: a meta-analysis

Increased risk of poor survival in ovarian cancer patients with high expression of SNAI2 and lymphovascular space invasion

Elevated plasma interleukin-37 playing an important role in acute coronary syndrome through suppression of ROCK activation

Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival

Prognostic value of expression of nuclear factor kappa-B/p65 in non-GCB DLBCL patients

The expression of Nectin-4 on the surface of ovarian cancer cells alters their ability to adhere, migrate, aggregate, and proliferate

Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22–CCR4 axis

Multicellular spheroids from normal and neoplastic thyroid tissues as a suitable model to test the effects of multikinase inhibitors

The Netrin-4/ Neogenin-1 axis promotes neuroblastoma cell survival and migration

Loss of FOXN3 in colon cancer activates beta-catenin/TCF signaling and promotes the growth and migration of cancer cells

Homeobox A11 hypermethylation indicates unfavorable prognosis in breast cancer

NFKB1 -94insertion/deletion ATTG polymorphism and cancer risk: Evidence from 50 case-control studies

Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models

SETMAR isoforms in glioblastoma: A matter of protein stability

Genetic polymorphisms in the telomere length-related gene ACYP2 are associated with the risk of colorectal cancer in a Chinese Han population

Phosphorylation of EB1 regulates the recruitment of CLIP-170 and p150^glued to the plus ends of astral microtubules

Targeting cancer stem cell propagation with palbociclib, a CDK4/6 inhibitor: Telomerase drives tumor cell heterogeneity

Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer

Visualization of exosome-mediated miR-210 transfer from hypoxic tumor cells

MiR-21 as prognostic biomarker in head and neck squamous cell carcinoma patients undergoing an organ preservation protocol

Antagonism of Interleukin-17A ameliorates experimental hepatic fibrosis by restoring the IL-10/STAT3-suppressed autophagy in hepatocytes

Risk assessment models to evaluate the necessity of prostate biopsies in North Chinese patients with 4-50 ng/mL PSA

Nutrient-induced FNIP degradation by SCFβ-TRCP regulates FLCN complex localization and promotes renal cancer progression

PDGF-D promotes cell growth, aggressiveness, angiogenesis and EMT transformation of colorectal cancer by activation of Notch1/Twist1 pathway

TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress

Sulodexide pretreatment attenuates renal ischemia-reperfusion injury in rats

Cost-effectiveness of gefitinib, icotinib, and pemetrexed-based chemotherapy as first-line treatments for advanced non-small cell lung cancer in China

The RNA-binding protein ESRP1 promotes human colorectal cancer progression

Hsp90 N- and C-terminal double inhibition synergistically suppresses Bcr-Abl-positive human leukemia cells

Abnormal expression of TGF-beta type II receptor isoforms contributes to acute myeloid leukemia

Spermatogonial stem cells and progenitors are refractory to reprogramming to pluripotency by the transcription factors Oct3/4, c-Myc, Sox2 and Klf4

Single nucleotide polymorphisms in ZNRD1-AS1 increase cancer risk in an Asian population

Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure–activity relationships

ITPR3 gene haplotype is associated with cervical squamous cell carcinoma risk in Taiwanese women

A novel splice variant of the protein tyrosine phosphatase PTPRJ that encodes for a soluble protein involved in angiogenesis

Antidepressant effect of recombinant NT4-NAP/AAV on social isolated mice through intranasal route

BRCA1-IRIS overexpression promotes and maintains the tumor initiating phenotype: implications for triple negative breast cancer early lesions

Retrospective analysis of 85 cases of intermediate-risk gastrointestinal stromal tumor

Angiomotin regulates prostate cancer cell proliferation by signaling through the Hippo-YAP pathway

Protective effect of tanshinone IIA against cardiac hypertrophy in spontaneously hypertensive rats through inhibiting the Cys-C/Wnt signaling pathway

Competing endogenous RNA network analysis identifies critical genes among the different breast cancer subtypes

COX-2/mPGES-1/PGE₂ cascade activation mediates uric acid-induced mesangial cell proliferation

VHL missense mutations in the p53 binding domain show different effects on p53 signaling and HIFα degradation in clear cell renal cell carcinoma

EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions

Genetic disruption of the pH_i-regulating proteins Na⁺/H⁺ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells

The biological properties of different Epstein-Barr virus strains explain their association with various types of cancers

Association of genetic polymorphisms with laryngeal carcinoma prognosis in a Chinese population

MET overexpression, gene amplification and relevant clinicopathological features in gastric adenocarcinoma

miR-124 represses the mesenchymal features and suppresses metastasis in Ewing sarcoma

Dual inhibition of PCDH9 expression by miR-215-5p up-regulation in gliomas

Cycling hypoxia affects cell invasion and proliferation through direct regulation of claudin1 / claudin7 expression, and indirect regulation of P18 through claudin7

Genomic analysis of exceptional responders to radiotherapy reveals somatic mutations in ATM

Src promotes castration-recurrent prostate cancer through androgen receptor-dependent canonical and non-canonical transcriptional signatures

Expression of Notch1 and Numb in small cell lung cancer

Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels

Is the pathological regression level of metastatic lymph nodes associated with oncologic outcomes following preoperative chemoradiotherapy in rectal cancer?

NIDO, AMOP and vWD domains of MUC4 play synergic role in MUC4 mediated signaling

The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells

Elevated spondin-2 expression correlates with progression and prognosis in gastric cancer

Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity

Blockade of the malignant phenotype by β-subunit selective noncovalent inhibition of immuno- and constitutive proteasomes

Associations between genetic variants in immunoregulatory genes and risk of non-Hodgkin lymphoma in a Chinese population

Folate intake, serum folate levels and esophageal cancer risk: an overall and dose-response meta-analysis

Baicalein has protective effects on the 17β-estradiol-induced transformation of breast epithelial cells

A potential prognostic lncRNA signature for predicting survival in patients with bladder urothelial carcinoma

Investigating the utility of human melanoma cell lines as tumour models

Elevated UHRF1 expression contributes to poor prognosis by promoting cell proliferation and metastasis in hepatocellular carcinoma

Genetic polymorphisms in TERT are associated with increased risk of esophageal cancer

Opposing roles of PIK3CA gene alterations to EZH2 signaling in non-muscle invasive bladder cancer

Targeted activation of AMPK by GSK621 ameliorates H₂O₂-induced damages in osteoblasts

Cytotoxic T-lymphocyte-associated protein 4 +49A/G polymorphisms contribute to the risk of type 1 diabetes in children: An updated systematic review and meta-analysis with trial sequential analysis

A short-term intervention with selenium affects expression of genes implicated in the epithelial-to-mesenchymal transition in the prostate

Establishment of a normal-derived estrogen receptor-positive cell line comparable to the prevailing human breast cancer subtype

Fertility-sparing surgery for patients with low-grade endometrial stromal sarcoma

The microbial community shifts of subgingival plaque in patients with generalized aggressive periodontitis following non-surgical periodontal therapy: a pilot study

Quantitative assessment of background parenchymal enhancement in breast magnetic resonance images predicts the risk of breast cancer

Effects of continuous renal replacement therapy on serum cytokines, neutrophil gelatinase-associated lipocalin, and prognosis in patients with severe acute kidney injury after cardiac surgery

Macrophage migration inhibitory factor: a potential driver and biomarker for head and neck squamous cell carcinoma

FoxO1: a novel insight into its molecular mechanisms in the regulation of skeletal muscle differentiation and fiber type specification

Mammary gland stem cells and their application in breast cancer

A systematic review and meta-analysis: Does hepatitis C virus infection predispose to the development of chronic kidney disease?

Bevacizumab combined with chemotherapy for ovarian cancer: an updated systematic review and meta-analysis of randomized controlled trials

FDA-approved medications that impair human spermatogenesis

Long noncoding RNAs in head and neck cancer

Clinical outcomes of laparoscopic-assisted synchronous bowel anastomoses for synchronous colorectal cancer: initial clinical experience

Magic year for multiple myeloma therapeutics: Key takeaways from the ASH 2015 annual meeting