Olaparib and somatic BRCA mutations

T315I⁺ tyrosine-kinase independent CML cells resistance

Chronic diabetic states worsen Alzheimer neuropathology and cognitive deficits accompanying disruption of calcium signaling in leptin-deficient APP/PS1 mice

Functional characterization of the lysosomal membrane protein TMEM192 in mice

Biological and clinical evidence for somatic mutations in BRCA1 and BRCA2 as predictive markers for olaparib response in high-grade serous ovarian cancers in the maintenance setting

Targeting BCR-ABL⁺ stem/progenitor cells and BCR-ABL-T315I mutant cells by effective inhibition of the BCR-ABL-Tyr177-GRB2 complex

Biological specificity of CDK4/6 inhibitors: dose response relationship, in vivo signaling, and composite response signature

Mitochondrial ASncmtRNA-1 and ASncmtRNA-2 as potent targets to inhibit tumor growth and metastasis in the RenCa murine renal adenocarcinoma model

Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway

Whole-exome sequencing identified genetic risk factors for asparaginase-related complications in childhood ALL patients

LncRNA RSU1P2 contributes to tumorigenesis by acting as a ceRNA against let-7a in cervical cancer cells

Recombinant TAT-BMI-1 fusion protein induces ex vivo expansion of human umbilical cord blood-derived hematopoietic stem cells

Resveratrol alleviates FFA and CCl₄ induced apoptosis in HepG2 cells via restoring endoplasmic reticulum stress

inFRank: a ranking-based identification of influential genes in biological networks

Rabies viruses leader RNA interacts with host Hsc70 and inhibits virus replication

Cell cycle protein Bora serves as a novel poor prognostic factor in multiple adenocarcinomas

Tumor suppressor BLU promotes TRAIL-induced apoptosis by downregulating NF-κB signaling in nasopharyngeal carcinoma

Development of diagnostic SCAR markers for genomic DNA amplifications in breast carcinoma by DNA cloning of high-GC RAMP-PCR fragments

Hsa_circ_0005986 inhibits carcinogenesis by acting as a miR-129-5p sponge and is used as a novel biomarker for hepatocellular carcinoma

MDI 301, a synthetic retinoid, depressed levels of matrix metalloproteinases and oxidative stress in diabetic dermal fibroblasts

miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A

A meta-analysis of HLA peptidome composition in different hematological entities: entity-specific dividing lines and "pan-leukemia" antigens

Risk of hepatitis C virus related hepatocellular carcinoma between subjects with spontaneous and treatment-induced viral clearance

Exome-based genome-wide association study and risk assessment using genetic risk score to prostate cancer in the Korean population

Circulating asymmetric dimethylarginine and the risk of preeclampsia: a meta-analysis based on 1338 participants

SNORD47, a box C/D snoRNA, suppresses tumorigenesis in glioblastoma

Exploring the key genes and pathways in enchondromas using a gene expression microarray

Clinical verification of plasma messenger RNA as novel noninvasive biomarker identified through bioinformatics analysis for lung cancer

Variant 2 of KIAA0101, antagonizing its oncogenic variant 1, might be a potential therapeutic strategy in hepatocellular carcinoma

Radioimmunotherapy for CD133(+) colonic cancer stem cells inhibits tumor development in nude mice

Survival benefit of glioblastoma patients after FDA approval of temozolomide concomitant with radiation and bevacizumab: A population-based study

Nano-pulse stimulation (NPS) ablate tumors and inhibit lung metastasis on both canine spontaneous osteosarcoma and murine transplanted hepatocellular carcinoma with high metastatic potential

The combination of prostate imaging reporting and data system version 2 (PI-RADS v2) and periprostatic fat thickness on multi-parametric MRI to predict the presence of prostate cancer

Circulating miR-21 serves as a serum biomarker for hepatocellular carcinoma and correlated with distant metastasis

Simultaneous in vitro generation of CD8 and CD4 T cells specific to three universal tumor associated antigens of WT1, survivin and TERT and adoptive T cell transfer for the treatment of acute myeloid leukemia

Olaparib in combination with irinotecan, cisplatin, and mitomycin C in patients with advanced pancreatic cancer

POU2F1 over-expression correlates with poor prognoses and promotes cell growth and epithelial-to-mesenchymal transition in hepatocellular carcinoma

Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer

Modulation of goat monocyte function by HCcyst-2, a secreted cystatin from Haemonchus contortus

A phase II trial of regorafenib in patients with metastatic and/or a unresectable gastrointestinal stromal tumor harboring secondary mutations of exon 17

Radium-223 for primary bone metastases in patients with hormone-sensitive prostate cancer after radical prostatectomy

Differentially expressed proteins in glioblastoma multiforme identified with a nanobody-based anti-proteome approach and confirmed by OncoFinder as possible tumor-class predictive biomarker candidates

Epigenetic modifiers upregulate MHC II and impede ovarian cancer tumor growth

Knockdown of PKM2 and GLS1 expression can significantly reverse oxaliplatin-resistance in colorectal cancer cells

IRF5 is associated with adverse postoperative prognosis of patients with non-metastatic clear cell renal cell carcinoma

DDX11-AS1 as potential therapy targets for human hepatocellular carcinoma

Risk of cancer in patients with heart failure who use digoxin: a 10-year follow-up study and cell-based verification

Urinary exosomes reveal protein signatures in hypertensive patients with albuminuria

Synergistic targeting of malignant pleural mesothelioma cells by MDM2 inhibitors and TRAIL agonists

An herbal formula attenuates collagen-induced arthritis via inhibition of JAK2-STAT3 signaling and regulation of Th17 cells in mice

Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1

Leflunomide/teriflunomide inhibit Epstein-Barr virus (EBV)-induced lymphoproliferative disease and lytic viral replication

The optimization of cell therapy by combinational application with apicidin-treated mesenchymal stem cells after myocardial infarction

Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer

The impact of EpCAM expression on response to chemotherapy and clinical outcomes in patients with epithelial ovarian cancer

Increased expression of long non-coding RNA CCEPR is associated with poor prognosis and promotes tumorigenesis in urothelial bladder carcinoma

EGF receptor lysosomal degradation is delayed in the cells stimulated with EGF-Quantum dot bioconjugate but earlier key events of endocytic degradative pathway are similar to that of native EGF

Impact of chronic unpredicted mild stress-induced depression on repaglinide fate via glucocorticoid signaling pathway

New interleukin-15 superagonist (IL-15SA) significantly enhances graft-versus-tumor activity

Histone modifications affect differential regulation of TGFβ- induced NADPH oxidase 4 (NOX4) by wild-type and mutant p53

Methylation regulates HEY1 expression in glioblastoma

Dexmedetomidine alleviates lipopolysaccharide-induced lung injury in Wistar rats

Characterization of tumor-associated T-lymphocyte subsets and immune checkpoint molecules in head and neck squamous cell carcinoma

Socioeconomic status is associated with global diabetes prevalence

FGF21 functions as a sensitive biomarker of APAP-treated patients and mice

Vitamin D receptor activation reduces VCaP xenograft tumor growth and counteracts ERG activity despite induction of TMPRSS2:ERG

M2 tumor-associated macrophages produce interleukin-17 to suppress oxaliplatin-induced apoptosis in hepatocellular carcinoma

Associations between APOE genotype and cerebral small-vessel disease: a longitudinal study

Interleukin-6-174G>C gene promoter polymorphism and prognosis in patients with cancer

Cell type-dependent HIF1 α-mediated effects of hypoxia on proliferation, migration and metastatic potential of human tumor cells

Methionine restriction on oxidative stress and immune response in dss-induced colitis mice

Actual over 10-year survival after liver resection for patients with intrahepatic cholangiocarcinoma

U94 of human herpesvirus 6 down-modulates Src, promotes a partial mesenchymal-to-epithelial transition and inhibits tumor cell growth, invasion and metastasis

Rapalogs can promote cancer cell stemness in vitro in a Galectin-1 and H-ras-dependent manner

The bidirectional association between oral cancer and esophageal cancer: A population-based study in Taiwan over a 28-year period

Intravoxel incoherent motion diffusion-weighted MR imaging parameters predict pathological classification in thymic epithelial tumors

The effect of thermal dose on hyperthermia-mediated inhibition of DNA repair through homologous recombination

The collagen receptor uPARAP/Endo180 as a novel target for antibody-drug conjugate mediated treatment of mesenchymal and leukemic cancers

Dimethyl fumarate reduces the risk of mycotoxins via improving intestinal barrier and microbiota

Riluzole exerts distinct antitumor effects from a metabotropic glutamate receptor 1-specific inhibitor on breast cancer cells

Stable and high expression of Galectin-8 tightly controls metastatic progression of prostate cancer

BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity

Ginkgolide K attenuates neuronal injury after ischemic stroke by inhibiting mitochondrial fission and GSK-3β-dependent increases in mitochondrial membrane permeability

FOXP3 inhibits cancer stem cell self-renewal via transcriptional repression of COX2 in colorectal cancer cells

Genome-wide methylome and chromatin interactome identify abnormal enhancer to be risk factor of breast cancer

Antagonistic effects of lycopene on cadmium-induced hippocampal dysfunctions in autophagy, calcium homeostatis and redox

Catecholamines facilitate VEGF-dependent angiogenesis via β₂-adrenoceptor-induced Epac1 and PKA activation

Dynamic changes in clonal cytogenetic architecture during progression of chronic lymphocytic leukemia in patients and patient-derived murine xenografts

Legume intake and risk of prostate cancer: a meta-analysis of prospective cohort studies

Hormonal therapy followed by chemotherapy or the reverse sequence as first-line treatment of hormone-responsive, human epidermal growth factor receptor-2 negative metastatic breast cancer patients: results of an observational study

Safety and efficacy of canaloplasty versus trabeculectomy in treatment of glaucoma

After microvascular decompression to treat trigeminal neuralgia, both immediate pain relief and recurrence rates are higher in patients with arterial compression than with venous compression

Predictive value of hematological markers of systemic inflammation for managing cervical cancer

Conversion to mammalian target of rapamycin inhibitors in kidney transplant recipients with de novo cancers

Phase III randomized trial of preoperative concurrent chemoradiotherapy versus preoperative radiotherapy for patients with locally advanced head and neck squamous cell carcinoma

Young breast cancer patients who develop distant metastasis after surgery have better survival outcomes compared with elderly counterparts

Endoscopic therapy for patients with pancreaticobiliary maljunction: a follow-up study

The lymph node ratio as an independent prognostic factor for node-positive triple-negative breast cancer

The clinical role of microRNA-21 as a promising biomarker in the diagnosis and prognosis of colorectal cancer: a systematic review and meta-analysis

Association between HIF1A rs11549465 polymorphism and risk of prostate cancer: a meta-analysis

The dark side of SOX2: cancer - a comprehensive overview

Dose dependent effects of cadmium on tumor angiogenesis

Mechanisms of PD-1/PD-L1 expression and prognostic relevance in non-Hodgkin lymphoma: a summary of immunohistochemical studies

Thalidomide combined with transcatheter artierial chemoembolzation for primary hepatocellular carcinoma: a systematic review and meta-analysis

Meta-analysis of the association between variants in MAPT and neurodegenerative diseases

Physical activity and telomere length: Impact of aging and potential mechanisms of action

Association between MMP2-1306 C/T polymorphism and prostate cancer susceptibility: a meta-analysis based on 3906 subjects

Correction: High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma