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Molecular signatures of age-associated chronic degeneration of shoulder muscles. See Raz et al.

Table of Contents

Research Perspectives

Integrative microRNA and gene profiling data analysis reveals novel biomarkers and mechanisms for lung cancer

https://doi.org/10.18632/oncotarget.7264

Ling Hu, Junmei Ai, Hui Long, Weijun Liu, Xiaomei Wang, Yi Zuo, Yan Li, Qingming Wu, and Youping Deng
8441-8454
Abstract  |  PDF  |  Full Text  |  How to cite

Research Perspectives: Neuroscience

Acute stress enhances the expression of neuroprotection and neurogenesisassociated genes in the hippocampus of a mouse restraint model

https://doi.org/10.18632/oncotarget.7225

Giuseppina Sannino, Lorenza Pasqualini, Eugenia Ricciardelli, Patricia Montilla, Laura Soverchia, Barbara Ruggeri, Silvia Falcinelli, Alessandra Renzi, Colleen Ludka, Thomas Kirchner, Thomas G. P. Grünewald, Roberto Ciccocioppo, Massimo Ubaldi, and Gary Hardiman
8455-8465
Abstract  |  PDF  |  Full Text  |  How to cite

Research Papers: Gerotarget (Focus on Aging)

Age and brain regiondependent αsynuclein oligomerization is attributed to alterations in intrinsic enzymes regulating αsynuclein phosphorylation in aging monkey brains

https://doi.org/10.18632/oncotarget.6445

Min Chen, Weiwei Yang, Xin Li, Xuran Li, Peng Wang, Feng Yue, Hui Yang, Piu Chan, and Shun Yu
8466-8480
Abstract  |  PDF  |  Full Text  |  How to cite

Potential role of PCTAIRE2 PCTAIRE3 and PHistone H4 in amyloid precursor proteindependent Alzheimer pathology

https://doi.org/10.18632/oncotarget.7380

Dale Chaput, Lisa Kirouac, Stanley M. Stevens, Jr., and Jaya Padmanabhan
8481-8497
Abstract  |  PDF  |  Full Text  |  How to cite

Moderate treadmill running exercise prior to tendon injury enhances wound healing in aging rats

https://doi.org/10.18632/oncotarget.7381

Jianying Zhang, Ting Yuan, and James H-C. Wang
8498-8512
Abstract  |  PDF  |  Full Text  |  How to cite

Molecular signatures of ageassociated chronic degeneration of shoulder muscles

https://doi.org/10.18632/oncotarget.7382

Yotam Raz, Jan Ferdinand Henseler, Arjen Kolk, Zuotian Tatum, Niels Kuipers Groosjohan, Nisha E. Verwey, Wibowo Arindrarto, Szymon M. Kielbasa, Jochem Nagels, Peter A. C. ’t Hoen, Rob G. H. H. Nelissen, and Vered Raz
8513-8523
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite  |  Press Release

Epigenetic clock analyses of cellular senescence and ageing

https://doi.org/10.18632/oncotarget.7383

Donna Lowe, Steve Horvath, and Kenneth Raj
8524-8531
Abstract  |  PDF  |  Full Text  |  How to cite

Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of agerelated macular degeneration

https://doi.org/10.18632/oncotarget.7384

Ahmed S. Ibrahim, Suchreet Mander, Khaled A. Hussein, Nehal M. Elsherbiny, Sylvia B. Smith, Mohamed Al-Shabrawey, and Amany Tawfik
8532-8545
Abstract  |  PDF  |  Full Text  |  How to cite

Highlighting the impact of aging on type I collagen: labelfree investigation using confocal reflectance microscopy and diffuse reflectance spectroscopy in 3D matrix model

https://doi.org/10.18632/oncotarget.7385

Marie Guilbert, Blandine Roig, Christine Terryn, Roselyne Garnotel, Pierre Jeannesson, Ganesh D. Sockalingum, Michel Manfait, François Perraut, Jean-Marc Dinten, Anne Koenig, and Olivier Piot
8546-8555
Abstract  |  PDF  |  Full Text  |  How to cite

Investigating the specific core geneticandepigenetic networks of cellular mechanisms involved in human aging in peripheral blood mononuclear cells

https://doi.org/10.18632/oncotarget.7388

Cheng-Wei Li, Wen-Hsin Wang, and Bor-Sen Chen
8556-8579
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Research Papers: Pathology

Integrative analysis of genomewide association studies and gene expression analysis identifies pathways associated with rheumatoid arthritis

https://doi.org/10.18632/oncotarget.7390

Mingming Zhang, Hongbo Mu, Hongchao Lv, Lian Duan, Zhenwei Shang, Jin Li, Yongshuai Jiang, and Ruijie Zhang
8580-8589
Abstract  |  PDF  |  Full Text  |  How to cite

Research Papers: Immunology

GITRL modulates the activities of p38 MAPK and STAT3 to promote Th17 cell differentiation in autoimmune arthritis

https://doi.org/10.18632/oncotarget.6535

Xinyi Tang, Jie Tian, Jie Ma, Jiemin Wang, Chen Qi, Ke Rui, Yungang Wang, Huaxi Xu, Liwei Lu, and Shengjun Wang
8590-8600
Abstract  |  PDF  |  Full Text  |  How to cite

Reviews

Molecular mechanisms of long noncoding RNAs on gastric cancer

https://doi.org/10.18632/oncotarget.6926

Tianwen Li, Xiaoyan Mo, Liyun Fu, Bingxiu Xiao, and Junming Guo
8601-8612
Abstract  |  PDF  |  Full Text  |  How to cite

The second European interdisciplinary Ewing sarcoma research summit – A joint effort to deconstructing the multiple layers of a complex disease

https://doi.org/10.18632/oncotarget.6937

Heinrich Kovar, James Amatruda, Erika Brunet, Stefan Burdach, Florencia Cidre-Aranaz, Enrique de Alava, Uta Dirksen, Wietske van der Ent, Patrick Grohar, Thomas G. P. Grünewald, Lee Helman, Peter Houghton, Kristiina Iljin, Eberhard Korsching, Marc Ladanyi, Elizabeth Lawlor, Stephen Lessnick, Joseph Ludwig, Paul Meltzer, Markus Metzler, Jaume Mora, Richard Moriggl, Takuro Nakamura, Theodore Papamarkou, Branka Radic Sarikas, Francoise Rédini, Guenther H. S. Richter, Claudia Rossig, Keri Schadler, Beat W. Schäfer, Katia Scotlandi, Nathan C. Sheffield, Anang Shelat, Ewa Snaar-Jagalska, Poul Sorensen, Kimberly Stegmaier, Elizabeth Stewart, Alejandro Sweet-Cordero, Karoly Szuhai, Oscar M. Tirado, Franck Tirode, Jeffrey Toretsky, Kalliopi Tsafou, Aykut Üren, Andrei Zinovyev, and Olivier Delattre
8613-8624
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Evolving roles of circadian rhythms in liver homeostasis and pathology

https://doi.org/10.18632/oncotarget.7065

Dexi Zhou, Yaqin Wang, Lu Chen, Leijuan Jia, Jie Yuan, Mei Sun, Wen Zhang, Peipei Wang, Jian Zuo, Zhenyu Xu, and Jiajie Luan
8625-8639
Abstract  |  PDF  |  Full Text  |  How to cite

Research Papers

Irsogladine maleate a gastric mucosal protectant suppresses intestinal polyp development in Apcmutant mice

https://doi.org/10.18632/oncotarget.7082

Wakana Onuma, Susumu Tomono, Shinngo Miyamoto, Gen Fujii, Takahiro Hamoya, Kyoko Fujimoto, Noriyuki Miyoshi, Fumio Fukai, Keiji Wakabayashi, and Michihiro Mutoh
8640-8652
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Small molecule screen for inhibitors of expression from canonical CREB response elementcontaining promoters

https://doi.org/10.18632/oncotarget.7085

Bryan Mitton, Katie Hsu, Ritika Dutta, Bruce C. Tiu, Nick Cox, Kevin G. McLure, Hee-Don Chae, Mark Smith, Elizabeth A. Eklund, David E. Solow-Cordero, and Kathleen M. Sakamoto
8653-8662
Abstract  |  PDF  |  Full Text  |  How to cite

The long noncoding RNA MALAT1 promotes tumordriven angiogenesis by upregulating proangiogenic gene expression

https://doi.org/10.18632/oncotarget.6675

Andrew E. Tee, Bing Liu, Renhua Song, Jinyan Li, Eddy Pasquier, Belamy B. Cheung, Cizhong Jiang, Glenn M. Marshall, Michelle Haber, Murray D. Norris, Jamie I. Fletcher, Marcel E. Dinger, and Tao Liu
8663-8675
Abstract  |  PDF  |  Full Text  |  How to cite

Hyperactive ERK and persistent mTOR signaling characterize vemurafenib resistance in papillary thyroid cancer cells

https://doi.org/10.18632/oncotarget.6779

Elyse K. Hanly, Neha Y. Tuli, Robert B. Bednarczyk, Robert Suriano, Jan Geliebter, Augustine L. Moscatello, Zbigniew Darzynkiewicz, and Raj K. Tiwari
8676-8687
Abstract  |  PDF  |  Full Text  |  How to cite

Identification of cancer chemopreventive isothiocyanates as direct inhibitors of the arylamine Nacetyltransferasedependent acetylation and bioactivation of aromatic amine carcinogens

https://doi.org/10.18632/oncotarget.7086

Romain Duval, Ximing Xu, Linh-Chi Bui, Cécile Mathieu, Emile Petit, Kevin Cariou, Robert H. Dodd, Jean-Marie Dupret, and Fernando Rodrigues-Lima
8688-8699
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Pololike kinase 1 inhibition sensitizes neuroblastoma cells for vinca alkaloidinduced apoptosis

https://doi.org/10.18632/oncotarget.3901

Sebastian Czaplinski, Manuela Hugle, Valerie Stiehl, and Simone Fulda
8700-8711
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

TERT promoter mutations and long telomere length predict poor survival and radiotherapy resistance in gliomas

https://doi.org/10.18632/oncotarget.6007

Ke Gao, Gang Li, Yiping Qu, Maode Wang, Bo Cui, Meiju Ji, Bingyin Shi, and Peng Hou
8712-8725
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

MicroRNAs 125a and 125b inhibit ovarian cancer cells through posttranscriptional inactivation of EIF4EBP1

https://doi.org/10.18632/oncotarget.6474

Maria Lee, Eun Jae Kim, and Myung Jae Jeon
8726-8742
Abstract  |  PDF  |  Full Text  |  How to cite

An individualized prognostic signature for gastric cancer patients treated with 5Fluorouracilbased chemotherapy and distinct multiomics characteristics of prognostic groups

https://doi.org/10.18632/oncotarget.7087

Xiangyu Li, Hao Cai, Weicheng Zheng, Mengsha Tong, Hongdong Li, Lu Ao, Jing Li, Guini Hong, Mengyao Li, Qingzhou Guan, Sheng Yang, Da Yang, Xu Lin, and Zheng Guo
8743-8755
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Overexpression of miR199a5p decreases esophageal cancer cell proliferation through repression of mitogenactivated protein kinase kinase kinase11 MAP3K11

https://doi.org/10.18632/oncotarget.6752

Kimberly A. Byrnes, Pornima Phatak, Daniel Mansour, Lan Xiao, Tongtong Zou, Jaladanki N. Rao, Douglas J. Turner, Jian-Ying Wang, and James M. Donahue
8756-8770
Abstract  |  PDF  |  Full Text  |  How to cite

Tumor sialylation impedes T cell mediated antitumor responses while promoting tumor associatedregulatory T cells

https://doi.org/10.18632/oncotarget.6822

Maurizio Perdicchio, Lenneke A. M. Cornelissen, Ingeborg Streng-Ouwehand, Steef Engels, Marleen I. Verstege, Louis Boon, Dirk Geerts, Yvette van Kooyk, and Wendy W. J. Unger
8771-8782
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

microRNA1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis

https://doi.org/10.18632/oncotarget.7088

Cen Zhang, Juan Liu, Chunwen Tan, Xuetian Yue, Yuhan Zhao, Jiaping Peng, Xiaolong Wang, Saurabh V. Laddha, Chang S. Chan, Shu Zheng, Wenwei Hu, and Zhaohui Feng
8783-8796
Abstract  |  PDF  |  Full Text  |  How to cite

Oblongifolin M an active compound isolated from a Chinese medical herb Garcinia oblongifolia potently inhibits enterovirus 71 reproduction through downregulation of ERp57

https://doi.org/10.18632/oncotarget.7122

Mengjie Wang, Qi Dong, Hua Wang, Yaqing He, Ying Chen, Hong Zhang, Rong Wu, Xinchun Chen, Boping Zhou, Jason He, Hsiang-Fu Kung, Canhua Huang, Yuquan Wei, Jian-dong Huang, Hongxi Xu, and Ming-Liang He
8797-8808
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

TGFβ/Smad3 signalling regulates the transition of bone marrowderived macrophages into myofibroblasts during tissue fibrosis

https://doi.org/10.18632/oncotarget.6604

Shuang Wang, Xiao-Ming Meng, Yee-Yung Ng, Frank Y. Ma, Shuang Zhou, Yang Zhang, Chen Yang, Xiao-Ru Huang, Jun Xiao, Ying-Ying Wang, Shuk-Man Ka, Yong-Jiang Tang, Arthur C.K. Chung, Ka-Fai To, David J. Nikolic-Paterson, and Hui-Yao Lan
8809-8822
Abstract  |  PDF  |  Full Text  |  How to cite

Epithelial but not stromal expression of collagen alpha1III is a diagnostic and prognostic indicator of colorectal carcinoma

https://doi.org/10.18632/oncotarget.6815

Xiao-Qing Wang, Zu-Xiong Tang, Dong Yu, Shu-Jian Cui, Ying-Hua Jiang, Qian Zhang, Jie Wang, Peng-Yuan Yang, and Feng Liu
8823-8838
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Prostate extracellular vesicles in patient plasma as a liquid biopsy platform for prostate cancer using nanoscale flow cytometry

https://doi.org/10.18632/oncotarget.6983

Colleen N. Biggs, Khurram M. Siddiqui, Ali A. Al-Zahrani, Siddika Pardhan, Sabine I. Brett, Qiu Q. Guo, Jun Yang, Philipp Wolf, Nicholas E. Power, Paul N. Durfee, Connor D. MacMillan, Jason L. Townson, Jeffrey C. Brinker, Neil E. Fleshner, Jonathan I. Izawa, Ann F. Chambers, Joseph L. Chin, and Hon S. Leong
8839-8849
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

NogoB receptor promotes the chemoresistance of human hepatocellular carcinoma via the ubiquitination of p53 protein

https://doi.org/10.18632/oncotarget.7091

Chengyong Dong, Baofeng Zhao, Fei Long, Ying Liu, Zhenzhen Liu, Song Li, Xuejun Yang, Deguang Sun, Haibo Wang, Qinlong Liu, Rui Liang, Yan Li, Zhenming Gao, Shujuan Shao, Qing Robert Miao, and Liming Wang
8850-8865
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Activated hepatic stellate cells promote liver cancer by induction of myeloidderived suppressor cells through cyclooxygenase2

https://doi.org/10.18632/oncotarget.6839

Yaping Xu, Wenxiu Zhao, Jianfeng Xu, Jie Li, Zaifa Hong, Zhenyu Yin, and Xiaomin Wang
8866-8878
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Generation of functional hepatocytes from human spermatogonial stem cells

https://doi.org/10.18632/oncotarget.7092

Zheng Chen, Min Sun, Qingqing Yuan, Minghui Niu, Chencheng Yao, Jingmei Hou, Hong Wang, Liping Wen, Yun Liu, Zheng Li, and Zuping He
8879-8895
Abstract  |  PDF  |  Full Text  |  How to cite

Bufalin enhances antitumor effect of paclitaxel on cervical tumorigenesis via inhibiting the integrin α2/β5/FAK signaling pathway

https://doi.org/10.18632/oncotarget.6840

Fei Liu, Duo Tong, Haoran Li, Mingming Liu, Jiajia Li, Ziliang Wang, and Xi Cheng
8896-8907
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Chromosomal anomalies at 1q 3 16q and mutations of SIX1 and DROSHA genes underlie Wilms tumor recurrences

https://doi.org/10.18632/oncotarget.6950

Filippo Spreafico, Sara Ciceri, Beatrice Gamba, Federica Torri, Monica Terenziani, Paola Collini, Fabio Macciardi, Paolo Radice, and Daniela Perotti
8908-8915
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Gene 33/Mig6 inhibits hexavalent chromiuminduced DNA damage and cell transformation in human lung epithelial cells

https://doi.org/10.18632/oncotarget.6866

Soyoung Park, Cen Li, Hong Zhao, Zbigniew Darzynkiewicz, and Dazhong Xu
8916-8930
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Tristetraprolin suppresses the EMT through the downregulation of Twist1 and Snail1 in cancer cells

https://doi.org/10.18632/oncotarget.7094

Nal Ae Yoon, Hyun Gun Jo, Unn Hwa Lee, Ji Hye Park, Ji Eun Yoon, Jinhyun Ryu, Sang Soo Kang, Young Joo Min, Seong-A Ju, Eun Hui Seo, In Young Huh, Byung Ju Lee, Jeong Woo Park, and Wha Ja Cho
8931-8943
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Expression of programmed cell deathligand 1 and its correlation with clinical outcomes in gliomas

https://doi.org/10.18632/oncotarget.6884

Jing Zeng, Xin-Ke Zhang, Hua-Dong Chen, Zhi-Hai Zhong, Qiu-Liang Wu, and Su-Xia Lin
8944-8955
Abstract  |  PDF  |  Full Text  |  How to cite

Adenovirusmediated downregulation of the ubiquitin ligase RNF8 sensitizes bladder cancer to radiotherapy

https://doi.org/10.18632/oncotarget.6909

Mei-Jun Zhao, Yan-Feng Song, Hai-Tao Niu, Ying-Xia Tian, Xu-Guang Yang, Kun Xie, Yu-Hong Jing, and De-Gui Wang
8956-8967
Abstract  |  PDF  |  Full Text  |  How to cite

Development of a metabolites risk score for oneyear mortality risk prediction in pancreatic adenocarcinoma patients

https://doi.org/10.18632/oncotarget.7108

Andrea Fontana, Massimiliano Copetti, Iole Maria Di Gangi, Tommaso Mazza, Francesca Tavano, Domenica Gioffreda, Fulvio Mattivi, Angelo Andriulli, Urska Vrhovsek, and Valerio Pazienza
8968-8978
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Multipolar mitosis and aneuploidy after chrysotile treatment: a consequence of abscission failure and cytokinesis regression

https://doi.org/10.18632/oncotarget.6924

Beatriz Araujo Cortez, Paula Rezende Teixeira, Sambra Redick, Stephen Doxsey, and Glaucia Maria Machado-Santelli
8979-8992
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Preclinical evaluation of a nanoformulated antihelminthic niclosamide in ovarian cancer

https://doi.org/10.18632/oncotarget.7113

Chi-Kang Lin, Meng-Yi Bai, Teh-Min Hu, Yu-Chi Wang, Tai-Kuang Chao, Shao-Ju Weng, Rui-Lan Huang, Po-Hsuan Su, and Hung-Cheng Lai
8993-9006
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

High level of αBcrystallin contributes to the progression of osteosarcoma

https://doi.org/10.18632/oncotarget.6928

Qing-Ming Shi, Jun Luo, Kai Wu, Ming Yin, Yu-Rong Gu, and Xi-Gao Cheng
9007-9016
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

EGFRactivating mutations DNA copy number abundance of ErbB family and prognosis in lung adenocarcinoma

https://doi.org/10.18632/oncotarget.7029

Hsuan-Yu Chen, Chia-Hsin Liu, Ya-Hsuan Chang, Sung-Liang Yu, Bing- Ching Ho, Chung-Ping Hsu, Tsung-Ying Yang, Kun-Chieh Chen, Kuo-Hsuan Hsu, Jeng-Sen Tseng, Jiun-Yi Hsia, Cheng-Yen Chuang, Chi-Sheng Chang, Yu-Cheng Li, Ker-Chau Li, Gee-Chen Chang, and Pan-Chyr Yang
9017-9025
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Parthenolide induces MITFM downregulation and senescence in patientderived MITFMhigh melanoma cell populations

https://doi.org/10.18632/oncotarget.7030

Mariusz L. Hartman, Beata Talar, Malgorzata Sztiller-Sikorska, Dariusz Nejc, and Malgorzata Czyz
9026-9040
Abstract  |  PDF  |  Full Text  |  How to cite

Medical Machiavellianism: the tradeoff between benefit and harm with targeted chemotherapy

https://doi.org/10.18632/oncotarget.6984

Bryan Oronsky, Corey Carter, Anna Scicinska, Arnold Oronsky, Neil Oronsky, Michelle Lybeck, and Jan Scicinski
9041-9045
Abstract  |  PDF  |  Full Text  |  How to cite

Delivery of improved oncolytic adenoviruses by mesenchymal stromal cells for elimination of tumorigenic pancreatic cancer cells

https://doi.org/10.18632/oncotarget.7031

Adam Kaczorowski, Katharina Hammer, Li Liu, Sabine Villhauer, Clifford Nwaeburu, Pei Fan, Zhefu Zhao, Jury Gladkich, Wolfgang Groß, Dirk M. Nettelbeck, and Ingrid Herr
9046-9059
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Common and distinct features of mammary tumors driven by Ptendeletion or activating Pik3ca mutation

https://doi.org/10.18632/oncotarget.6985

Jeff C. Liu, Dong-Yu Wang, Sean E. Egan, and Eldad Zacksenhaus
9060-9068
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

CDK9 inhibitors selectively target estrogen receptorpositive breast cancer cells through combined inhibition of MYB and MCL1 expression

https://doi.org/10.18632/oncotarget.6997

Partha Mitra, Ren-Ming Yang, James Sutton, Robert G. Ramsay, and Thomas J. Gonda
9069-9083
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Splicing factor mutations predict poor prognosis in patients with de novo acute myeloid leukemia

https://doi.org/10.18632/oncotarget.7000

Hsin-An Hou, Chieh-Yu Liu, Yuan-Yeh Kuo, Wen-Chien Chou, Cheng-Hong Tsai, Chien-Chin Lin, Liang-In Lin, Mei-Hsuan Tseng, Ying-Chieh Chiang, Ming-Chih Liu, Chia-Wen Liu, Jih-Luh Tang, Ming Yao, Chi-Cheng Li, Shang-Yi Huang, Bor-Sheng Ko, Szu-Chun Hsu, Chien-Yuan Chen, Chien-Ting Lin, Shang-Ju Wu, Woei Tsay, and Hwei-Fang Tien
9084-9101
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

High efficacy of intravesical treatment of metformin on bladder cancer in preclinical model

https://doi.org/10.18632/oncotarget.6933

Mei Peng, Qiongli Su, Qing Zeng, Le Li, Zhihong Liu, Lei Xue, Yan Cheng, Yanjun Huang, Ting Tao, Hongwei Lv, Xiaohui Li, Xiaojun Tao, Peng Guo, Alex F. Chen, and Xiaoping Yang
9102-9117
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

MIIP accelerates epidermal growth factor receptor protein turnover and attenuates proliferation in nonsmall cell lung cancer

https://doi.org/10.18632/oncotarget.7001

Jing Wen, Jianhua Fu, Yihong Ling, and Wei Zhang
9118-9134
Abstract  |  PDF  |  Full Text  |  How to cite

Lapatinib inhibits CIP2A/PP2A/pAkt signaling and induces apoptosis in triple negative breast cancer cells

https://doi.org/10.18632/oncotarget.7035

Chun-Yu Liu, Ming-Hung Hu, Chia-Jung Hsu, Chun-Teng Huang, Duen-Shian Wang, Wen-Chun Tsai, Yi-Ting Chen, Chia-Han Lee, Pei-Yi Chu, Chia-Chi Hsu, Ming-Huang Chen, Chung-Wai Shiau, Ling-Ming Tseng, and Kuen-Feng Chen
9135-9149
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Exo70 is transcriptionally upregulated by hepatic nuclear factor 4α and contributes to cell cycle control in hepatoma cells

https://doi.org/10.18632/oncotarget.7133

Yujie Zhao, Jihuan Hou, Panying Mi, Liyuan Mao, Liang Xu, Youyu Zhang, Li Xiao, Hanwei Cao, Wenqing Zhang, Bing Zhang, Gang Song, Tianhui Hu, and Yan-yan Zhan
9150-9162
Abstract  |  PDF  |  Full Text  |  How to cite

Differential regulation of mTOR signaling determines sensitivity to AKT inhibition in diffuse large B cell lymphoma

https://doi.org/10.18632/oncotarget.7036

Scott A. Ezell, Suping Wang, Teeru Bihani, Zhongwu Lai, Shaun E. Grosskurth, Suprawee Tepsuporn, Barry R. Davies, Dennis Huszar, and Kate F. Byth
9163-9174
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Cold inducible RNA binding protein upregulation in pituitary corticotroph adenoma induces corticotroph cell proliferation via Erk signaling pathway

https://doi.org/10.18632/oncotarget.7037

Fangfang Jian, Yufan Chen, Guang Ning, Wei Fu, Hao Tang, Xiao Chen, Yao Zhao, Lili Zheng, Sijian Pan, Weiqing Wang, Liuguan Bian, and Qingfang Sun
9175-9187
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells

https://doi.org/10.18632/oncotarget.6942

Maria Goulielmaki, Evangelos Koustas, Eirini Moysidou, Margarita Vlassi, Takehiko Sasazuki, Senji Shirasawa, George Zografos, Eftychia Oikonomou, and Alexander Pintzas
9188-9221
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

MiR129 triggers autophagic flux by regulating a novel Notch1/ E2F7/Beclin1 axis to impair the viability of human malignant glioma cells

https://doi.org/10.18632/oncotarget.7003

Xiong Chen, Yingying Zhang, Yingying Shi, Haiwei Lian, Huilin Tu, Song Han, Jun Yin, Biwen Peng, Beiyan Zhou, Xiaohua He, and Wanhong Liu
9222-9235
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The correlation between microRNA4903p and TGFα in endometrial carcinoma tumorigenesis and progression

https://doi.org/10.18632/oncotarget.7061

Kai-Xuan Sun, Ying Chen, Shuo Chen, Bo-Liang Liu, Miao-Xiao Feng, Zhi-Hong Zong, and Yang Zhao
9236-9249
Abstract  |  PDF  |  Full Text  |  How to cite

In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO GDC0449 or GLI GANT61 inhibitors

https://doi.org/10.18632/oncotarget.7062

Monica Benvenuto, Laura Masuelli, Enrico De Smaele, Massimo Fantini, Rosanna Mattera, Danilo Cucchi, Elena Bonanno, Enrica Di Stefano, Giovanni Vanni Frajese, Augusto Orlandi, Isabella Screpanti, Alberto Gulino, Andrea Modesti, and Roberto Bei
9250-9270
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

MicroRNA497 impairs the growth of chemoresistant neuroblastoma cells by targeting cell cycle survival and vascular permeability genes

https://doi.org/10.18632/oncotarget.7005

Aroa Soriano, Laia París-Coderch, Luz Jubierre, Alba Martínez, Xiangyu Zhou, Olga Piskareva, Isabella Bray, Isaac Vidal, Ana Almazán-Moga, Carla Molist, Josep Roma, José R. Bayascas, Oriol Casanovas, Raymond L. Stallings, José Sánchez de Toledo, Soledad Gallego, and Miguel F. Segura
9271-9287
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

[68Ga]PentixaforPET/CT for imaging of chemokine receptor 4 expression in small cell lung cancer initial experience

https://doi.org/10.18632/oncotarget.7063

Constantin Lapa, Katharina Lückerath, Martina Rudelius, Jan-Stefan Schmid, Alexander Schoene, Andreas Schirbel, Samuel Samnick, Theo Pelzer, Andreas K. Buck, Saskia Kropf, Hans-Jürgen Wester, and Ken Herrmann
9288-9295
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

A novel small molecule agent displays potent antimyeloma activity by inhibiting the JAK2STAT3 signaling pathway

https://doi.org/10.18632/oncotarget.6974

Zubin Zhang, Hongwu Mao, Xiaolin Du, Jingyu Zhu, Yujia Xu, Siyu Wang, Xin Xu, Peng Ji, Yang Yu, Biyin Cao, Kunkun Han, Tingjun Hou, Zhuan Xu, Yan Kong, Gaofeng Jiang, Xiaowen Tang, Chunhua Qiao, and Xinliang Mao
9296-9308
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Does bevacizumab impact antiEGFR therapy efficacy in metastatic colorectal cancer

https://doi.org/10.18632/oncotarget.7008

Valentin Derangère, Jean David Fumet, Romain Boidot, Leila Bengrine, Emeric Limagne, Angélique Chevriaux, Julie Vincent, Sylvain Ladoire, Lionel Apetoh, Cédric Rébé, and François Ghiringhelli
9309-9321
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Fatty acid activated PPARγ promotes tumorigenicity of prostate cancer cells by up regulating VEGF via PPAR responsive elements of the promoter

https://doi.org/10.18632/oncotarget.6975

Farzad S. Forootan, Shiva S. Forootan, Xiaojun Gou, Jin Yang, Bichong Liu, Danqing Chen, Majed Saad Al Fayi, Waseem Al-Jameel, Philip S. Rudland, Syed A. Hussain, and Youqiang Ke
9322-9339
Abstract  |  PDF  |  Full Text  |  How to cite

Altered Hepa16 cells by dimethyl sulfoxide DMSOtreatment induce antitumor immunity in vivo

https://doi.org/10.18632/oncotarget.7009

Zhengyu Jiang, Hongxia Zhang, Ye Wang, Bin Yu, Chen Wang, Changcheng Liu, Juan Lu, Fei Chen, Minjun Wang, Xinlu Yu, Jiahao Lin, Xinghua Pan, Pin Wang, and Haiying Zhu
9340-9352
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Paracrine effect of GTP cyclohydrolase and angiopoietin1 interaction in stromal fibroblasts on tumor Tie2 activation and breast cancer growth

https://doi.org/10.18632/oncotarget.6981

Liye Chen, Xin Zeng, Esther Kleibeuker, Francesca Buffa, Alessandro Barberis, Russell D. Leek, Ioannis Roxanis, Wei Zhang, Andrew Worth, John S. Beech, Adrian L. Harris, and Shijie Cai
9353-9367
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

miR143 or miR145 overexpression increases cetuximabmediated antibodydependent cellular cytotoxicity in human colon cancer cells

https://doi.org/10.18632/oncotarget.7010

Sofia E. Gomes, André E. S. Simões, Diane M. Pereira, Rui E. Castro, Cecília M. P. Rodrigues, and Pedro M. Borralho
9368-9387
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

A 20Sprotopanoxadiol derivative overcomes multidrug resistance by antagonizing ATPbinding cassette subfamily B member 1 transporter function

https://doi.org/10.18632/oncotarget.7011

Gang Chen, Junhua Liu, Wantao Chen, Qin Xu, Meng Xiao, Lihong Hu, Li Mao, and Xu Wang
9388-9403
Abstract  |  PDF  |  Full Text  |  How to cite

Identifying anticancer drug response related genes using an integrative analysis of transcriptomic and genomic variations with cell linebased drug perturbations

https://doi.org/10.18632/oncotarget.7012

Yi Sun, Wei Zhang, Yunqin Chen, Qin Ma, Jia Wei, and Qi Liu
9404-9419
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population

https://doi.org/10.18632/oncotarget.7137

Li-Xin Qiu, Lei Cheng, Jing He, Zhi-Rui Zhou, Meng-Yun Wang, Fei Zhou, Wei-Jian Guo, Jin Li, Meng-Hong Sun, Xiao-Yan Zhou, Ya-Nong Wang, Ya-Jun Yang, Jiu-Cun Wang, Li Jin, Xiao-Dong Zhu, and Qing-Yi Wei
9420-9428
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

A novel smallmolecule compound targeting CD147 inhibits the motility and invasion of hepatocellular carcinoma cells

https://doi.org/10.18632/oncotarget.6990

Zhi-guang Fu, Li Wang, Hong-yong Cui, Jian-long Peng, Shi-jie Wang, Jie-jie Geng, Ji-de Liu, Fei Feng, Fei Song, Ling Li, Ping Zhu, Jian-li Jiang, and Zhi-nan Chen
9429-9447
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

HBV polymerase overexpression due to large core gene deletion enhances hepatoma cell growth by binding inhibition of microRNA100

https://doi.org/10.18632/oncotarget.7021

Ya-Hui Huang, Ying-Hsin Tseng, Wey-Ran Lin, George Hung, Tse-Ching Chen, Tong-Hong Wang, Wei-Chen Lee, and Chau-Ting Yeh
9448-9461
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Physalin A exerts antitumor activity in nonsmall cell lung cancer cell lines by suppressing JAK/STAT3 signaling

https://doi.org/10.18632/oncotarget.7051

Fanfan Zhu, Chunyan Dai, Yufei Fu, Jacky F.C. Loo, Dajin Xia, Sizhi P. Gao, Zhongjun Ma, and Zhe Chen
9462-9476
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Inactivation of BRCA2 in human cancer cells identifies a subset of tumors with enhanced sensitivity towards death receptormediated apoptosis

https://doi.org/10.18632/oncotarget.7053

Enrico N. De Toni, Andreas Ziesch, Antonia Rizzani, Helga-Paula Török, Sandra Hocke, Shuai Lü, Shao-Chun Wang, Tomas Hucl, Burkhard Göke, Christiane Bruns, and Eike Gallmeier
9477-9490
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

High level of BRD4 promotes nonsmall cell lung cancer progression

https://doi.org/10.18632/oncotarget.7068

Yun-Fei Liao, Yong-Bing Wu, Xiang Long, Shu-Qiang Zhu, Chun Jin, Jian-Jun Xu, and Jian-Yong Ding
9491-9500
Abstract  |  PDF  |  Full Text  |  How to cite

Dehydropeptidase 1 promotes metastasis through regulation of Ecadherin expression in colon cancer

https://doi.org/10.18632/oncotarget.7033

Sang Yoon Park, Seon-Jin Lee, Hee Jun Cho, Tae Woo Kim, Jong-Tae Kim, Jae Wha Kim, Chul-Ho Lee, Bo-Yeon Kim, Young Il Yeom, Jong-Seok Lim, Younghee Lee, and Hee Gu Lee
9501-9512
Abstract  |  PDF  |  Full Text  |  How to cite

Depletion of CABYRa/b sensitizes lung cancer cells to TRAILinduced apoptosis through YAP/p73mediated DR5 upregulation

https://doi.org/10.18632/oncotarget.7069

Qianqian Xiao, Zunlei Qian, Weiqing Zhang, Jin Liu, Enze Hu, Jinsan Zhang, Mingying Li, Junhao Wang, Fei Kong, Yunguang Li, Rui Wang, Xiaohua Tan, Dacheng He, and Xueyuan Xiao
9513-9524
Abstract  |  PDF  |  Full Text  |  How to cite

The Notch pathway promotes the cancer stem cell characteristics of CD90+ cells in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.6672

Jing Luo, Peng Wang, Ronghua Wang, Jinlin Wang, Man Liu, Si Xiong, Yawen Li, and Bin Cheng
9525-9537
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint

https://doi.org/10.18632/oncotarget.7070

Laura Di Magno, Alessio Basile, Sonia Coni, Simona Manni, Giulia Sdruscia, Davide D’Amico, Laura Antonucci, Paola Infante, Enrico De Smaele, Danilo Cucchi, Elisabetta Ferretti, Lucia Di Marcotullio, Isabella Screpanti, and Gianluca Canettieri
9538-9549
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

A TET2 rs3733609 C/T genotype is associated with predisposition to the myeloproliferative neoplasms harboring JAK2V617F and confers a proliferative potential on erythroid lineages

https://doi.org/10.18632/oncotarget.7072

Xiao-hui Shen, Nan-nan Sun, Ya-fei Yin, Su-fang Liu, Xiao-liu Liu, Hong-ling Peng, Chong-wen Dai, Yun-xiao Xu, Ming-yang Deng, Yun-ya Luo, Wen-li Zheng, and Guang-sen Zhang
9550-9560
Abstract  |  PDF  |  Full Text  |  How to cite

Antibody targeting facilitates effective intratumoral siRNA nanoparticle delivery to HER2overexpressing cancer cells

https://doi.org/10.18632/oncotarget.7076

Maria C. Palanca-Wessels, Garrett C. Booth, Anthony J. Convertine, Brittany B. Lundy, Geoffrey Y. Berguig, Michael F. Press, Patrick S. Stayton, and Oliver W. Press
9561-9575
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Risk stratification based on change in plasma EpsteinBarr virus DNA load after treatment in nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.7083

Yuan Zhang, Wen-Fei Li, Yan-Ping Mao, Rui Guo, Ling-Long Tang, Hao Peng, Ying Sun, Qing Liu, Lei Chen, and Jun Ma
9576-9585
Abstract  |  PDF  |  Full Text  |  How to cite

Polycomb complex protein BMI1 promotes invasion and metastasis of pancreatic cancer stem cells by activating PI3K/AKT signaling an ex vivo in vitro and in vivo study

https://doi.org/10.18632/oncotarget.7078

Min-Cong Wang, Min Jiao, Tao Wu, Li Jing, Jie Cui, Hui Guo, Tao Tian, Zhi-ping Ruan, Yong-Chang Wei, Li-Li Jiang, Hai-Feng Sun, Lan-Xuan Huang, Ke-Jun Nan, and Chun-Li Li
9586-9599
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Clinical Research Papers

Prevalence and spectrum of BRCA germline variants in mainland Chinese familial breast and ovarian cancer patients

https://doi.org/10.18632/oncotarget.7144

Yeong C. Kim, Linli Zhao, Hanwen Zhang, Ye Huang, Jian Cui, Fengxia Xiao, Bradley Downs, and San Ming Wang
9600-9612
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Case Reports

Nasal NK/T cell lymphoma presents with longterm nasal blockage and fever: a rare case report and literature review

https://doi.org/10.18632/oncotarget.7386

Hai Zou, Ke-Hua Pan, Liang Wu, Hong-Ying Pan, Ya-Hui Ding, and Ming-Hua Zheng
9613-9617
Abstract  |  PDF  |  Full Text  |  How to cite


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