Targeted next generation sequencing identifies two novel mutations in SEPN1 in rigid spine muscular dystrophy 1

Probucol prevents atrial ion channel remodeling in an alloxan-induced diabetes rabbit model

P120 regulates beta-catenin nuclear translocation through E-cadherin endocytosis in ventilator-induced lung injury

Effects of dietary vitamin E deficiency on systematic pathological changes and oxidative stress in fish

A novel mechanism underlies atrazine toxicity in quails (Coturnix Coturnix coturnix): triggering ionic disorder via disruption of ATPases

Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells

Recombinant Haemonchus contortus 24 kDa excretory/secretory protein (rHcES-24) modulate the immune functions of goat PBMCs in vitro

Interleukin-8 holds promise to serve as a molecular adjuvant in DNA vaccination model against Streptococcus iniae infection in fish

Chenodeoxycholic acid activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis

Relapsed diffuse large B-cell lymphoma present different genomic profiles between early and late relapses

Two subtypes of colorectal tumor with distinct molecular features in familial adenomatous polyposis

MiRNA203 suppresses the expression of protumorigenic STAT1 in glioblastoma to inhibit tumorigenesis

Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surface

Efficacy of splint therapy for the management of temporomandibular disorders: a meta-analysis

E-cadherin downregulation sensitizes PTEN-mutant tumors to PI3Kβ silencing

Acquisition cancer stemness, mesenchymal transdifferentiation, and chemoresistance properties by chronic exposure of oral epithelial cells to arecoline

In vitro comparison of conventional hyperthermia and modulated electro-hyperthermia

Activation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cells

IPMK and β-catenin mediate PLC-β1-dependent signaling in myogenic differentiation

Lunasin is a novel therapeutic agent for targeting melanoma cancer stem cells

Application of pharmacologically induced transcriptomic profiles to interrogate PI3K-Akt-mTOR pathway activity associated with cancer patient prognosis

The pathological behaviors and prognostic factors of Chinese and Japanese colorectal cancers from general hospitals: a comparative study of the inpatients with surgical operation

Circulating microRNA124-3p, microRNA9-3p and microRNA196b-5p may be potential signatures for differential diagnosis of thyroid nodules

Meta-analysis of gene expression and integrin-associated signaling pathways in papillary renal cell carcinoma subtypes

Metformin potentiates anti-tumor effect of resveratrol on pancreatic cancer by down-regulation of VEGF-B signaling pathway

The andean anticancer herbal product BIRM causes destabilization of androgen receptor and induces caspase-8 mediated-apoptosis in prostate cancer

Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia

Interaction between susceptibility loci in cGAS-STING pathway, MHC gene and HPV infection on the risk of cervical precancerous lesions in Chinese population

Upregulation of HSF1 in estrogen receptor positive breast cancer

Generation of V α13/β21⁺T cell specific target CML cells by TCR gene transfer

LDB1 overexpression is a negative prognostic factor in colorectal cancer

Impact of Polo-like kinase 1 inhibitors on human adipose tissue-derived mesenchymal stem cells

The hedgehog inhibitor GANT61 sensitizes prostate cancer cells to ionizing radiation both in vitro and in vivo

Dicer suppresses MMP-2-mediated invasion and VEGFA-induced angiogenesis and serves as a promising prognostic biomarker in human clear cell renal cell carcinoma

Compound genetically engineered mouse models of cancer reveal dual targeting of ALK1 and endoglin as a synergistic opportunity to impinge on angiogenic TGF-β signaling

Ral A, via activating the mitotic checkpoint, sensitizes cells lacking a functional Nf1 to apoptosis in the absence of protein kinase C

H₂S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair

Inducible expression of cancer-testis antigens in human prostate cancer

FOXC1 promotes melanoma by activating MST1R/PI3K/AKT pathway and is associated with poor prognosis in melanoma

Celastrol increases osteosarcoma cell lysis by γδ T cells through up-regulation of death receptors

Next-generation sequencing identifies articular cartilage and subchondral bone miRNAs after ESWT on early osteoarthritis knee

Diagnostic and prognostic value of serum MACC1 in breast cancer patients

Hypermethylation of the HIC1 promoter and aberrant expression of HIC1/SIRT1 contribute to the development of thyroid papillary carcinoma

MED12 mutations in breast phyllodes tumors: evidence of temporal tumoral heterogeneity and identification of associated critical signaling pathways

Ammonium tetrathiomolybdate treatment targets the copper transporter ATP7A and enhances sensitivity of breast cancer to cisplatin

EZH2 inhibition promotes epithelial-to-mesenchymal transition in ovarian cancer cells

A network meta-analysis on the efficacy of sixteen targeted drugs in combination with chemotherapy for treatment of advanced/metastatic colorectal cancer

Upregulation of long noncoding RNA HOTTIP promotes metastasis of esophageal squamous cell carcinoma via induction of EMT

Human sulfatase 1 exerts anti-tumor activity by inhibiting the AKT/ CDK4 signaling pathway in melanoma

p16^INK4a suppresses BRCA1-deficient mammary tumorigenesis

MiR-21 and MiR-155 promote non-small cell lung cancer progression by downregulating SOCS1, SOCS6, and PTEN

Vitexin suppresses autophagy to induce apoptosis in hepatocellular carcinoma via activation of the JNK signaling pathway

A network meta-analysis for toxicity of eight chemotherapy regimens in the treatment of metastatic/advanced breast cancer

Meta-analysis of laparoscopic versus open liver resection for colorectal liver metastases

Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling

Small heterodimer partner 1 directly interacts with NS5A viral protein and has a key role in HCV related liver cell transformation

FGFR3, as a receptor tyrosine kinase, is associated with differentiated biological functions and improved survival of glioma patients

Combining a GSI and BCL-2 inhibitor to overcome melanoma’s resistance to current treatments

Heparan sulfate hexasaccharide selectively inhibits cancer stem cells self-renewal by activating p38 MAP kinase

PPARα, a predictor of patient survival in glioma, inhibits cell growth through the E2F1/miR-19a feedback loop

Unraveling the expression of the oncogene YAP1, a Wnt/beta-catenin target, in adrenocortical tumors and its association with poor outcome in pediatric patients

Keratin 13 expression reprograms bone and brain metastases of human prostate cancer cells

Pyroptosis is involved in the pathogenesis of human hepatocellular carcinoma

Clinical data from the real world: efficacy of Crizotinib in Chinese patients with advanced ALK-rearranged non-small cell lung cancer and brain metastases

OTX015 (MK-8628), a novel BET inhibitor, exhibits antitumor activity in non-small cell and small cell lung cancer models harboring different oncogenic mutations

MTOR inhibition reversed drug resistance after combination radiation with erlotinib in lung adenocarcinoma

Enhanced circulating transforming growth factor beta 1 is causally associated with an increased risk of hepatocellular carcinoma: a mendelian randomization meta-analysis

KCNJ3 is a new independent prognostic marker for estrogen receptor positive breast cancer patients

The Aurora kinase A inhibitor TC-A2317 disrupts mitotic progression and inhibits cancer cell proliferation

A phase 1 study of oral ridaforolimus in pediatric patients with advanced solid tumors

Gremlin inhibits UV-induced skin cell damages via activating VEGFR2-Nrf2 signaling

Blood and lung microRNAs as biomarkers of pulmonary tumorigenesis in cigarette smoke-exposed mice

Dot1l expression predicts adverse postoperative prognosis of patients with clear-cell renal cell carcinoma

DNA methylation promotes paired box 2 expression via myeloid zinc finger 1 in endometrial cancer

C5a receptor (CD88) promotes motility and invasiveness of gastric cancer by activating RhoA

Different BCR/Abl protein suppression patterns as a converging trait of chronic myeloid leukemia cell adaptation to energy restriction

MiR-384 inhibits human colorectal cancer metastasis by targeting KRAS and CDC42

H₂O₂ treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway

Diagnostic value of fibulin-3 for malignant pleural mesothelioma: A systematic review and meta-analysis

Heregulin-expressing HER2-positive breast and gastric cancer exhibited heterogeneous susceptibility to the anti-HER2 agents lapatinib, trastuzumab and T-DM1

Nucleotide excision repair pathway gene polymorphisms are linked to breast cancer risk in a Chinese population

Hepatitis B virus X protein influences enrichment profiles of H3K9me3 on promoter regions in human hepatoma cell lines

Elevated expression of ZNF217 promotes prostate cancer growth by restraining ferroportin-conducted iron egress

MKP-1 attenuates LPS-induced blood-testis barrier dysfunction and inflammatory response through p38 and IκBα pathways

Ultraviolet radiation-induced differential microRNA expression in the skin of hairless SKH1 mice, a widely used mouse model for dermatology research

Alteration of colonic epithelial cell differentiation in mice deficient for glucosaminyl N-deacetylase/N-sulfotransferase 4

PD 0332991, a selective cyclin D kinase 4/6 inhibitor, sensitizes lung cancer cells to treatment with epidermal growth factor receptor tyrosine kinase inhibitors

Oncolytic adenovirus coexpressing interleukin-12 and shVEGF restores antitumor immune function and enhances antitumor efficacy

Mutation analysis of a Chinese family with oculocutaneous albinism

Induction of mitochondria-mediated apoptosis and PI3K/Akt/ mTOR-mediated autophagy by aflatoxin B₂ in hepatocytes of broilers

PTEN dephosphorylates AKT to prevent the expression of GLUT1 on plasmamembrane and to limit glucose consumption in cancer cells

EGF induces epithelial-mesenchymal transition through phospho-Smad2/3-Snail signaling pathway in breast cancer cells

Inhibition of Chk1 with the small molecule inhibitor V158411 induces DNA damage and cell death in an unperturbed S-phase

Mechanisms of transcriptional activation of the stimulator of interferon genes by transcription factors CREB and c-Myc

Expressions of miR-30c and let-7a are inversely correlated with HMGA2 expression in squamous cell carcinoma of the vulva

Targeted depletion of PIK3R2 induces regression of lung squamous cell carcinoma

IL-37 suppresses hepatocellular carcinoma growth by converting pSmad3 signaling from JNK/pSmad3L/c-Myc oncogenic signaling to pSmad3C/P21 tumor-suppressive signaling

Subsite-specific association of DEAD box RNA helicase DDX60 with the development and prognosis of oral squamous cell carcinoma

RanBPM (RanBP9) regulates mouse c-Kit receptor level and is essential for normal development of bone marrow progenitor cells

Combination of COX-2 expression and PIK3CA mutation as prognostic and predictive markers for celecoxib treatment in breast cancer

Elevated serum granulocyte-macrophage colony-stimulating factor levels during radiotherapy predict favorable outcomes in lung and esophageal cancer

Jumonji domain-containing protein 1A promotes cell growth and progression via transactivation of c-Myc expression and predicts a poor prognosis in cervical cancer

Tumor specific delivery and therapy mediate by integrin β6-target immunoliposomes for β6-siRNA in colon carcinoma

Folate intake and the risk of endometrial cancer: A meta-analysis

CXCR4 antagonists suppress small cell lung cancer progression

Prognostic significance of L1 cell adhesion molecule in cancer patients: A systematic review and meta-analysis

Sulforaphane inhibits proliferation and invasive activity of everolimus-resistant kidney cancer cells in vitro

Laricitrin ameliorates lung cancer-mediated dendritic cell suppression by inhibiting signal transducer and activator of transcription 3

Prognostic and predictive values of CDK1 and MAD2L1 in lung adenocarcinoma

Overexpression of ATPase Na+/K+ transporting alpha 1 polypeptide, ATP1A1, correlates with clinical diagnosis and progression of esophageal squamous cell carcinoma

Ribosomal protein L34 promotes the proliferation, invasion and metastasis of pancreatic cancer cells

Tumor-targeting adenovirus OBP-401 inhibits primary and metastatic tumor growth of triple-negative breast cancer in orthotopic nude-mouse models

The relationship between polymorphisms of XRCC5 genes with astrocytoma prognosis in the Han Chinese population

Thrombin inhibition and cisplatin block tumor progression in ovarian cancer by alleviating the immunosuppressive microenvironment

Sunitinib for the treatment of benign and malignant neoplasms from von Hippel-Lindau disease: A single-arm, prospective phase II clinical study from the PREDIR group

Isoliquiritigenin decreases the incidence of colitis-associated colorectal cancer by modulating the intestinal microbiota

Kallikrein-related peptidase 6 induces chemotherapeutic resistance by attenuating auranofin-induced cell death through activation of autophagy in gastric cancer

Enumeration and targeted analysis of KRAS, BRAF and PIK3CA mutations in CTCs captured by a label-free platform: Comparison to ctDNA and tissue in metastatic colorectal cancer

TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress

Pin1 induces the ADP-induced migration of human dental pulp cells through P2Y1 stabilization

YWHAE silencing induces cell proliferation, invasion and migration through the up-regulation of CDC25B and MYC in gastric cancer cells: new insights about YWHAE role in the tumor development and metastasis process

Identification of an HSP90 modulated multi-step process for ERBB2 degradation in breast cancer cells

Quantification of tumor-derived cell free DNA(cfDNA) by digital PCR (DigPCR) in cerebrospinal fluid of patients with BRAF^V600 mutated malignancies

Cancer cell CCL5 mediates bone marrow independent angiogenesis in breast cancer

Sorafenib pretreatment enhances radiotherapy through targeting MEK/ERK/NF-κB pathway in human hepatocellular carcinoma-bearing mouse model

Impact of diabetes-related gene polymorphisms on the clinical characteristics of type 2 diabetes Chinese Han population

Diisononyl phthalate aggravates allergic dermatitis by activation of NF-kB

Association of multiple genetic variants with breast cancer susceptibility in the Han Chinese population

Synergistic antitumor activity of the combination of salubrinal and rapamycin against human cholangiocarcinoma cells

Expression analysis and clinical significance of eIF4E, VEGF-C, E-cadherin and MMP-2 in colorectal adenocarcinoma

Low dose triptolide reverses chemoresistance in adult acute lymphoblastic leukemia cells via reactive oxygen species generation and DNA damage response disruption

Prevalence and clinical significance of BRCA1/2 germline and somatic mutations in Taiwanese patients with ovarian cancer

EGFR kinase inhibitors and gastric acid suppressants in EGFR-mutant NSCLC: a retrospective database analysis of potential drug interaction

Exosomal long noncoding RNA CRNDE-h as a novel serum-based biomarker for diagnosis and prognosis of colorectal cancer

Bendamustine for the treatment of relapsed or refractory peripheral T cell lymphomas: A French retrospective multicenter study

Phase II trial of concurrent chemoradiotherapy with L-asparaginase and MIDLE chemotherapy for newly diagnosed stage I/II extranodal NK/T-cell lymphoma, nasal type (CISL-1008)

Low-dose green tea intake reduces incidence of atrial fibrillation in a Chinese population

Is chronic hepatitis B infection a protective factor for the progression of advanced pancreatic ductal adenocarcinoma? An analysis from a large multicenter cohort study

Epigenetic regulation of cancer biology and anti-tumor immunity by EZH2

Role of DNA repair machinery and p53 in the testicular germ cell cancer: a review

MicroRNAs for osteosarcoma in the mouse: a meta-analysis