Serotonin and sleep-promoting neurons

Perineuronal nets in neurodegeneration

CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins

p73 expression is regulated by ribosomal protein RPL26 through mRNA translation and protein stability

A randomized phase II trial comparing chemoimmunotherapy with or without bevacizumab in previously untreated patients with chronic lymphocytic leukemia

Expression of functional alternative telomerase RNA component gene in mouse brain and in motor neurons cells protects from oxidative stress

Presence of lacunar infarctions is associated with the spatial navigation impairment in patients with mild cognitive impairment: a DTI study

Targeting EZH1 and EZH2 contributes to the suppression of fibrosis-associated genes by miR-214-3p in cardiac myofibroblasts

Dysregulation of macrophage polarization is associated with the metastatic process in osteosarcoma

High frequency of clonal IG and T-cell receptor gene rearrangements in histiocytic and dendritic cell neoplasms

Novel mutations c.28G>T (p.Ala10Ser) and c.189G>T (p.Glu63Asp) in WDR62 associated with early onset acanthosis and hyperkeratosis in a patient with autosomal recessive microcephaly type 2

Ischemic preconditioning attenuates ischemia/reperfusion injury in rat steatotic liver: role of heme oxygenase-1-mediated autophagy

New conception for the development of hypertension in preeclampsia

Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential

MiR-99b-5p expression and response to tyrosine kinase inhibitor treatment in clear cell renal cell carcinoma patients

Clinical outcomes of advanced-stage glassy cell carcinoma of the uterine cervix: a need for reappraisal

Endoplasmic reticulum stress-induced neuronal inflammatory response and apoptosis likely plays a key role in the development of diabetic encephalopathy

The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma

A scoring system basing pathological parameters to predict regional lymph node metastasis after preoperative chemoradiotherapy for locally advanced rectal cancer: implication for local excision

A rational approach for cancer stem-like cell isolation and characterization using CD44 and prominin-1(CD133) as selection markers

Inhibition of autophagy inhibits the conversion of cardiac fibroblasts to cardiac myofibroblasts

Copy number gain of VCX, X-linked multi-copy gene, leads to cell proliferation and apoptosis during spermatogenesis

Analysis of angiogenesis related factors in glioblastoma, peritumoral tissue and their derived cancer stem cells

Simultaneous high expression of PLD1 and Sp1 predicts a poor prognosis for pancreatic ductal adenocarcinoma patients

Fatty acid synthase is a primary target of MiR-15a and MiR-16-1 in breast cancer

A functional signal profiling test for identifying a subset of HER2-negative breast cancers with abnormally amplified HER2 signaling activity

In Vivo magnetic resonance imaging of xenografted tumors using FTH1 reporter gene expression controlled by a tet-on switch

CCR10/CCL27 crosstalk contributes to failure of proteasome-inhibitors in multiple myeloma

Inhibition of calcium-activated chloride channel ANO1 suppresses proliferation and induces apoptosis of epithelium originated cancer cells

Quantitative assessment of polymorphisms in H19 lncRNA and cancer risk: a meta-analysis of 13,392 cases and 18,893 controls

The microRNA miR-33a suppresses IL-6-induced tumor progression by binding Twist in gallbladder cancer

Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy

miR-125b regulates differentiation and metabolic reprogramming of T cell acute lymphoblastic leukemia by directly targeting A20

Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease

Serum carboxypeptidaseA4 levels predict liver metastasis in colorectal carcinoma

CD133⁺CD24^lo defines a 5-Fluorouracil-resistant colon cancer stem cell-like phenotype

SIN3A and SIN3B differentially regulate breast cancer metastasis

MFHAS1 promotes colorectal cancer progress by regulating polarization of tumor-associated macrophages via STAT6 signaling pathway

Optimization of radiotherapy for neck carcinoma metastasis from unknown primary sites: a meta-analysis

PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway

Fasudil, an inhibitor of Rho-associated coiled-coil kinase, improves cognitive impairments induced by smoke exposure

A 5-day cytoreductive chemotherapy followed by haplo-identical hsct (FA5-BUCY) as a tumor-ablative regimen improved the survival of patients with advanced hematological malignancies

Metformin treatment reduces temozolomide resistance of glioblastoma cells

Nuclear transcription factor Nrf2 suppresses prostate cancer cells growth and migration through upregulating ferroportin

miR128-1 inhibits the growth of glioblastoma multiforme and glioma stem-like cells via targeting BMI1 and E2F3

KRAS mutations in blood circulating cell-free DNA: a pancreatic cancer case-control

Comparative analysis of protein interactome networks prioritizes candidate genes with cancer signatures

Identification of a serum circulating lncRNA panel for the diagnosis and recurrence prediction of bladder cancer

Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathogenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma

Premalignant alteration assessment in liver-like tissue derived from embryonic stem cells by aristolochic acid I exposure

Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death

XPO1 inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IκBα and overcomes acquired proteasome inhibitor resistance in human multiple myeloma

c-Myc is regulated by HIF-2α in chronic hypoxia and influences sensitivity to 5-FU in colon cancer

DDR2 overexpression in urothelial carcinoma indicates an unfavorable prognosis: a large cohort study

Transcriptional upregulation of c-MET is associated with invasion and tumor budding in colorectal cancer

Attenuation of cancer-initiating cells stemness properties by abrogating S100A4 calcium binding ability in head and neck cancers

Mitotic arrest-induced phosphorylation of Mcl-1 revisited using two-dimensional gel electrophoresis and phosphoproteomics: nine phosphorylation sites identified

The nuclear corepressor 1 and the thyroid hormone receptor β suppress breast tumor lymphangiogenesis

The prevalence of EGFR mutation in patients with non-small cell lung cancer: a systematic review and meta-analysis

Overexpression of stathmin promotes metastasis and growth of malignant solid tumors: a systemic review and meta-analysis

Dietary iron intake and breast cancer risk: modulation by an antioxidant supplementation

ING4 suppresses tumor angiogenesis and functions as a prognostic marker in human colorectal cancer

Antagonizing miR-218-5p attenuates Wnt signaling and reduces metastatic bone disease of triple negative breast cancer cells

Autophagy negatively regulates tumor cell proliferation through phosphorylation dependent degradation of the Notch1 intracellular domain

Synergistic targeting of Sp1, a critical transcription factor for myeloma cell growth and survival, by panobinostat and proteasome inhibitors

Antitumor activity of curcumin is involved in down-regulation of YAP/TAZ expression in pancreatic cancer cells

Radiosensitizing effect of lapatinib in human epidermal growth factor receptor 2-positive breast cancer cells

GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity

Defective ciliogenesis in thyroid hürthle cell tumors is associated with increased autophagy

Therapeutic effects of umbilical cord blood plasma in a rat model of acute ischemic stroke

Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism

Proteomic analysis reveals diverse proline hydroxylation-mediated oxygen-sensing cellular pathways in cancer cells

Anti-metastatic effect of the TM4SF5-specific peptide vaccine and humanized monoclonal antibody on colon cancer in a mouse lung metastasis model

The anti-tumor role of NK cells in vivo pre-activated and re-stimulated by interleukins in acute lymphoblastic leukemia

Spatio-temporal regulation of EGFR signaling by the Eps15 homology domain-containing protein 3 (EHD3)

The BET bromodomain inhibitor exerts the most potent synergistic anticancer effects with quinone-containing compounds and anti-microtubule drugs

Genetic interactions between the hedgehog co-receptors Gas1 and Boc regulate cell proliferation during murine palatogenesis

Resveratrol post-treatment protects against neonatal brain injury after hypoxia-ischemia

Notch1-WISP-1 axis determines the regulatory role of mesenchymal stem cell-derived stromal fibroblasts in melanoma metastasis

Differentially expressed miRNAs in triple negative breast cancer between African-American and non-Hispanic white women

Targeting heterogeneity of adrenocortical carcinoma: Evaluation and extension of preclinical tumor models to improve clinical translation

Lentivirus-mediated RNAi knockdown of insulin-like growth factor-1 receptor inhibits the growth and invasion of hepatocellular carcinoma via down-regulating midkine expression

Downregulation of osteoprotegerin expression in metastatic colorectal carcinoma predicts recurrent metastasis and poor prognosis

Preclinical activity of MBM-5 in gastrointestinal cancer by inhibiting NEK2 kinase activity

DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation

Intravoxel incoherent motion (IVIM) in diffusion-weighted imaging (DWI) for Hepatocellular carcinoma: correlation with histologic grade

Association between miR-199a rs74723057 and MET rs1621 polymorphisms and the risk of hepatocellular carcinoma

A combined gene expression and functional study reveals the crosstalk between N-Myc and differentiation-inducing microRNAs in neuroblastoma cells

ON 01910.Na (rigosertib) inhibits PI3K/Akt pathway and activates oxidative stress signals in head and neck cancer cell lines

Delivery of a peptide-drug conjugate targeting the blood brain barrier improved the efficacy of paclitaxel against glioma

Near-infrared photoimmunotherapy with galactosyl serum albumin in a model of diffuse peritoneal disseminated ovarian cancer

Identification of DNA-PKcs as a primary resistance factor of salinomycin in osteosarcoma cells

Targeted NGS, array-CGH, and patient-derived tumor xenografts for precision medicine in advanced breast cancer: a single-center prospective study

Effect of marital status on the survival of patients with hepatocellular carcinoma treated with surgical resection: an analysis of 13,408 patients in the surveillance, epidemiology, and end results (SEER) database

Investigating the mechanism of hepatocellular carcinoma progression by constructing genetic and epigenetic networks using NGS data identification and big database mining method

Utilization of leukapheresis and CD4 positive selection in Treg isolation and the ex-vivo expansion for a clinical application in transplantation and autoimmune disorders

OutLyzer: software for extracting low-allele-frequency tumor mutations from sequencing background noise in clinical practice

Identification of KLK10 as a therapeutic target to reverse trastuzumab resistance in breast cancer

KRAS-mutation status dependent effect of zoledronic acid in human non-small cell cancer preclinical models

Deubiquitinase USP9X deubiquitinates β-catenin and promotes high grade glioma cell growth

In pursuit of synergy: An investigation of the PI3K/mTOR/MEK co-targeted inhibition strategy in NSCLC

WM130 preferentially inhibits hepatic cancer stem-like cells by suppressing AKT/GSK3β/β-catenin signaling pathway

Epigallocatechin-3-gallate(EGCG) suppresses melanoma cell growth and metastasis by targeting TRAF6 activity

Stimulation of prolactin receptor induces STAT-5 phosphorylation and cellular invasion in glioblastoma multiforme

MicroRNA-101 reverses temozolomide resistance by inhibition of GSK3β in glioblastoma

DIRC3 and near NABP1 genetic polymorphisms are associated laryngeal squamous cell carcinoma patient survival

Comparison of the expression and function of Lin28A and Lin28B in colon cancer

miR-31 affects colorectal cancer cells by inhibiting autophagy in cancer-associated fibroblasts

Multiple mutations of lung squamous cell carcinoma shared common mechanisms

Therapeutic efficacy of the bromodomain inhibitor OTX015/MK-8628 in ALK-positive anaplastic large cell lymphoma: an alternative modality to overcome resistant phenotypes

SIRT1 promotes metastasis of human osteosarcoma cells

Enhancement of 5-FU sensitivity by the proapoptotic rpL3 gene in p53 null colon cancer cells through combined polymer nanoparticles

Breast cancer cells obtain an osteomimetic feature via epithelial-mesenchymal transition that have undergone BMP2/RUNX2 signaling pathway induction

Increased phosphorylation of eIF2α in chronic myeloid leukemia cells stimulates secretion of matrix modifying enzymes

Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes

Glypican-5 suppresses Epithelial-Mesenchymal Transition of the lung adenocarcinoma by competitively binding to Wnt3a

Nickel chloride-induced apoptosis via mitochondria- and Fas-mediated caspase-dependent pathways in broiler chickens

Volatile oil from Saussurea lappa exerts antitumor efficacy by inhibiting epithelial growth factor receptor tyrosine kinase-mediated signaling pathway in hepatocellular carcinoma

Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis

The survival and clinicopathological differences between patients with stage IIIA and stage II rectal cancer: An analysis of 12,036 patients in the SEER database

Novel mutations in CRB1 gene identified in a chinese pedigree with retinitis pigmentosa by targeted capture and next generation sequencing

MicroRNA-206 attenuates the growth and angiogenesis in non-small cell lung cancer cells by blocking the 14-3-3ζ/STAT3/HIF-1α/VEGF signaling

Orthoreovirus outer-fiber proteins are substrates for SUMO-conjugating enzyme Ubc9

Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models

Synergistic effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway or NUP214-ABL1 fusion protein in human Acute Lymphoblastic Leukemia

TRIM71 suppresses tumorigenesis via modulation of Lin28B-let-7-HMGA2 signaling

RSK2 activity mediates glioblastoma invasiveness and is a potential target for new therapeutics

Cellular effects of fluorodeoxyglucose: Global changes in the lipidome and alteration in intracellular transport

Tumor necrosis factor-alpha promoter polymorphism 308 G/A is not significantly associated with esophageal cancer risk: a meta-analysis

Interleukin-13 suppresses interleukin-10 via inhibiting A20 in peripheral B cells of patients with food allergy

CD99 triggering induces methuosis of Ewing sarcoma cells through IGF-1R/RAS/Rac1 signaling

PD-L1 promoter methylation is a prognostic biomarker for biochemical recurrence-free survival in prostate cancer patients following radical prostatectomy

miR-186 affects the proliferation, invasion and migration of human gastric cancer by inhibition of Twist1

Motor activity of centromere-associated protein-E contributes to its localization at the center of the midbody to regulate cytokinetic abscission

Establishment of mitochondrial pyruvate carrier 1 (MPC1) gene knockout mice with preliminary gene function analyses

Mitomycin C treatment induces resistance and enhanced migration via phosphorylated Akt in aggressive lung cancer cells

Biodegradable double-targeted PTX-mPEG-PLGA nanoparticles for ultrasound contrast enhanced imaging and antitumor therapy in vitro

Diagnostic accuracy of DNA methylation for head and neck cancer varies by sample type and number of markers tested

New combined microRNA and protein plasmatic biomarker panel for pancreatic cancer

Serological immune response against ADAM10 pro-domain is associated with favourable prognosis in stage III colorectal cancer patients

Adjuvant radiation therapy in stage I seminoma: 20 years of oncologic results

Imatinib and polypharmacy in very old patients with chronic myeloid leukemia: effects on response rate, toxicity and outcome

Radiation combined with temozolomide contraindicated for young adults diagnosed with anaplastic glioma