Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors

Spatial learning and memory impairments are associated with increased neuronal activity in 5XFAD mouse as measured by manganese-enhanced magnetic resonance imaging

A novel polymer-free ciglitazone-coated vascular stent: in vivo and ex vivo analysis of stent endothelialization in a rabbit iliac artery model

Downregulation of the phosphatase JKAP/DUSP22 in T cells as a potential new biomarker of systemic lupus erythematosus nephritis

Expression and regulation of immune-modulatory enzyme indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation

Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival

Acquired savolitinib resistance in non-small cell lung cancer arises via multiple mechanisms that converge on MET-independent mTOR and MYC activation

Cancer megafunds with in silico and in vitro validation: accelerating cancer drug discovery via financial engineering without financial crisis

Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1

Circulating resistin levels and obesity-related cancer risk: A meta-analysis

A novel multi-target RNAi adenovirus inhibits hepatoma cell proliferation, migration, and induction of angiogenesis

ATM protein is deficient in over 40% of lung adenocarcinomas

A cancer specific hypermethylation signature of the TERT promoter predicts biochemical relapse in prostate cancer: a retrospective cohort study

CD147 knockdown improves the antitumor efficacy of trastuzumab in HER2-positive breast cancer cells

Honokiol suppresses lung tumorigenesis by targeting EGFR and its downstream effectors

Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling

Role of SATB2 in human pancreatic cancer: Implications in transformation and a promising biomarker

Her2 oncogene transformation enhances 5-aminolevulinic acid-mediated protoporphyrin IX production and photodynamic therapy response

Acute myeloid leukemia stem cell markers in prognosis and targeted therapy: potential impact of BMI-1, TIM-3 and CLL-1

UHRF1 regulates global DNA hypomethylation and is associated with poor prognosis in esophageal squamous cell carcinoma

PTEN expression is a prognostic marker for patients with non-small cell lung cancer: a systematic review and meta-analysis of the literature

Deletion of epidermal Rac1 inhibits HPV-8 induced skin papilloma formation and facilitates HPV-8- and UV-light induced skin carcinogenesis

Inhibition of PlexA1-mediated brain tumor growth and tumor-associated angiogenesis using a transmembrane domain targeting peptide

KDM4B plays an important role in mitochondrial apoptosis by upregulating HAX1 expression in colorectal cancer

RSUME is implicated in tumorigenesis and metastasis of pancreatic neuroendocrine tumors

Sunitinib as salvage treatment including potent anti-tumor activity in carcinomatous ulcers for patients with multidrug-resistant metastatic breast cancer

Long non-coding RNA ANRIL promotes the invasion and metastasis of thyroid cancer cells through TGF-β/Smad signaling pathway

IRWRLDA: improved random walk with restart for lncRNA-disease association prediction

Anti-cancer effects of nitrogen-containing bisphosphonates on human cancer cells

Structural basis for exploring the allosteric inhibition of human kidney type glutaminase

Ligand activated progesterone receptor B drives autophagy-senescence transition through a Beclin-1/Bcl-2 dependent mechanism in human breast cancer cells

DcR3 gene polymorphisms are associated with sporadic breast infiltrating ductal carcinoma in Northeast Chinese women

Increased expression of EHF contributes to thyroid tumorigenesis through transcriptionally regulating HER2 and HER3

Prognostic value of long non-coding RNA UCA1 in human solid tumors

KRAS mutation as a prognostic factor in ampullary adenocarcinoma: a meta-analysis and review

Therapeutic implication of HER2 in advanced biliary tract cancer

Co-expression analysis identifies long noncoding RNA SNHG1 as a novel predictor for event-free survival in neuroblastoma

Ethacrynic acid improves the antitumor effects of irreversible epidermal growth factor receptor tyrosine kinase inhibitors in breast cancer

ABCB1 as predominant resistance mechanism in cells with acquired SNS-032 resistance

Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission

Simultaneous activation and inhibition of autophagy sensitizes cancer cells to chemotherapy

Preconditioning of bone marrow mesenchymal stem cells with hydrogen sulfide improves their therapeutic potential

Comparison of the EORTC criteria and PERCIST in solid tumors: a pooled analysis and review

Suppression of breast cancer metastasis through the inactivation of ADP-ribosylation factor 1

Radio-frequency plasma polymerized biodegradable carrier for in vivo release of cis-platinum

Combretastatin-A4 phosphate improves the distribution and antitumor efficacy of albumin-bound paclitaxel in W256 breast carcinoma model

Bromodomain inhibitor OTX015 (MK-8628) combined with targeted agents shows strong in vivo antitumor activity in lymphoma

miR-497-5p inhibits cell proliferation and invasion by targeting KCa3.1 in angiosarcoma

Matriptase regulates c-Met mediated proliferation and invasion in inflammatory breast cancer

Impacts of the mTOR gene polymorphisms rs2536 and rs2295080 on breast cancer risk in the Chinese population

IL-1α and IL-1β-producing macrophages populate lung tumor lesions in mice

UBE2C cell-free RNA in urine can discriminate between bladder cancer and hematuria

The putative tumor suppressor gene EphA7 is a novel BMI-1 target

MicroRNA 744-3p promotes MMP-9-mediated metastasis by simultaneously suppressing PDCD4 and PTEN in laryngeal squamous cell carcinoma

A clinical observation of Chinese chronic myelogenous leukemia patients after discontinuation of tyrosine kinase inhibitors

Proteolysis-a characteristic of tumor-initiating cells in murine metastatic breast cancer

Factors predicting organ-specific distant metastasis in patients with completely resected lung adenocarcinoma

C23 promotes tumorigenesis via suppressing p53 activity

Aberrant DR5 transport through disruption of lysosomal function suggests a novel mechanism for receptor activation

Prognostic nomogram for post-surgical treatment with adjuvant TACE in hepatitis B virus-related hepatocellular carcinoma

G-protein-coupled receptors mediate ω-3 PUFAs-inhibited colorectal cancer by activating the Hippo pathway

Targeting antisense mitochondrial ncRNAs inhibits murine melanoma tumor growth and metastasis through reduction in survival and invasion factors

CD44 and CD24 coordinate the reprogramming of nasopharyngeal carcinoma cells towards a cancer stem cell phenotype through STAT3 activation

Up-regulation of microRNA let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl

Growth factor progranulin promotes tumorigenesis of cervical cancer via PI3K/Akt/mTOR signaling pathway

The DDGP (cisplatin, dexamethasone, gemcitabine, and pegaspargase) regimen for treatment of extranodal natural killer (NK)/T-cell lymphoma, nasal type

The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice

A recombinantly tailored β-defensin that displays intensive macropinocytosis-mediated uptake exerting potent efficacy against K-Ras mutant pancreatic cancer

TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2

Doxorubicin-triggered self-assembly of native amphiphilic peptides into spherical nanoparticles

Prognostic values of normal preoperative serum cancer markers for gastric cancer

Elevated eukaryotic elongation factor 2 expression is involved in proliferation and invasion of lung squamous cell carcinoma

DCUN1D3 activates SCF^SKP2 ubiquitin E3 ligase activity and cell cycle progression under UV damage

Detection of the T790M mutation of EGFR in plasma of advanced non–small cell lung cancer patients with acquired resistance to tyrosine kinase inhibitors (West Japan oncology group 8014LTR study)

The reliable assurance of detecting somatic mutations in cancer-related genes by next-generation sequencing: the results of external quality assessment in China

Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells

Targeting a novel cancer-driving protein (LAPTM4B-35) by a small molecule (ETS) to inhibit cancer growth and metastasis

Randomized clinical trial: Nucleos(t)ide analogues improved survival of CHB-related HCC patients via reducing severity and progression of malignancy

Nuclear localization of B7-H4 in pulmonary adenocarcinomas presenting as a solitary pulmonary nodule

Clinical utility of microRNA-378 as early diagnostic biomarker of human cancers: a meta-analysis of diagnostic test

Oxaliplatin, 5-fluorouracil and leucovorin (FOLFOX) as second-line therapy for patients with advanced urothelial cancer

Anti-miR-203 suppresses ER-positive breast cancer growth and stemness by targeting SOCS3

Diagnostic value of microRNAs in asbestos exposure and malignant mesothelioma: systematic review and qualitative meta-analysis

Gene mutations and actionable genetic lesions in mantle cell lymphoma

Angiogenesis in pancreatic ductal adenocarcinoma: A controversial issue

An updated meta-analysis of 37 case-control studies on the association between NFKB1 -94ins/del ATTG promoter polymorphism and cancer susceptibility

Decellularized scaffolds in regenerative medicine

Advanced new strategies for metastatic cancer treatment by therapeutic stem cells and oncolytic virotherapy

Cancer diagnostics: The journey from histomorphology to molecular profiling

Weekly versus three weeks chemotherapy for advanced ovarian cancer: a meta-analysis