CDK4/6 inhibition: the late harvest cycle begins

LIGHTing tumor up for checkpoint blockade

PIP₃-binding proteins promote age-dependent protein aggregation and limit survival in C. elegans

Noninvasive ventilation improves cardiac function in patients with chronic heart failure

Mitochondrial transplantation attenuates hypoxic pulmonary hypertension

Deciphering bacterial community changes in zucker diabetic fatty rats based on 16S rRNA gene sequences analysis

Abnormal organization of white matter networks in patients with subjective cognitive decline and mild cognitive impairment

β-MSCs: successful fusion of MSCs with β-cells results in a β-cell like phenotype

Saikosaponin a inhibits LPS-induced inflammatory response by inducing liver X receptor alpha activation in primary mouse macrophages

Identification of IFN-γ-producing T cells as the main mediators of the side effects associated to mouse interleukin-15 sustained exposure

IRF3 is an important molecule in the UII/UT system and mediates immune inflammatory injury in acute liver failure

PCP4/PEP19 promotes migration, invasion and adhesion in human breast cancer MCF-7 and T47D cells

Efficient therapeutic delivery by a novel cell-permeant peptide derived from KDM4A protein for antitumor and antifibrosis

Increased FGF19 copy number is frequently detected in hepatocellular carcinoma with a complete response after sorafenib treatment

A four gene signature of chromosome instability (CIN4) predicts for benefit from taxanes in the NCIC-CTG MA21 clinical trial

Functional role and tobacco smoking effects on methylation of CYP1A1 gene in prostate cancer

X chromosome-wide identification of SNVs in microRNA genes and non-obstructive azoospermia risk in Han Chinese population

MicroRNA-224 inhibits proliferation and migration of breast cancer cells by down-regulating Frizzled 5 expression

Therapeutic strategy with artificially-designed i-lncRNA targeting multiple oncogenic microRNAs exhibits effective antitumor activity in diffuse large B-cell lymphoma

Membranous CD24 drives the epithelial phenotype of pancreatic cancer

Androgen receptor activity modulates responses to cisplatin treatment in bladder cancer

Inhibition of Cdc42 is essential for Mig-6 suppression of cell migration induced by EGF

Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease

MiR-223-5p works as an oncomiR in vulvar carcinoma by TP63 suppression

Gene network analysis reveals a novel 22-gene signature of carbon metabolism in hepatocellular carcinoma

A comprehensive characterization of rare mitochondrial DNA variants in neuroblastoma

Concerted action of IFN-α and IFN-λ induces local NK cell immunity and halts cancer growth

Dynein axonemal heavy chain 8 promotes androgen receptor activity and associates with prostate cancer progression

Interleukin-13 receptor α2 is associated with poor prognosis in patients with gastric cancer after gastrectomy

Androgen receptor as potential therapeutic target in metastatic endometrial cancer

The contribution of serum hepatitis B virus load in the carcinogenesis and prognosis of hepatocellular carcinoma: evidence from two meta-analyses

Desferal regulates hCtr1 and transferrin receptor expression through Sp1 and exhibits synergistic cytotoxicity with platinum drugs in oxaliplatin-resistant human cervical cancer cells in vitro and in vivo

Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients

Prognostic significance and function of the vacuolar H⁺-ATPase subunit V1E1 in esophageal squamous cell carcinoma

Targeted gene silencing of CCL2 inhibits triple negative breast cancer progression by blocking cancer stem cell renewal and M2 macrophage recruitment

Lin28B promotes Müller glial cell de-differentiation and proliferation in the regenerative rat retinas

PA-MSHA in combination with EGFR tyrosine kinase inhibitor: A new strategy to overcome the drug resistance of non-small cell lung cancer cells

Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion

Sohlh2 suppresses epithelial to mesenchymal transition in breast cancer via downregulation of IL-8

Cancer-secreted AGR2 induces programmed cell death in normal cells

β-catenin signaling is required for RAS-driven thyroid cancer through PI3K activation

Disruption of the EZH2/miRNA/β-catenin signaling suppresses aerobic glycolysis in glioma

CD1d expression on chronic lymphocytic leukemia B cells affects disease progression and induces T cell skewing in CD8 positive and CD4CD8 double negative T cells

Decreased expression of microRNA-320a promotes proliferation and invasion of non-small cell lung cancer cells by increasing VDAC1 expression

Accumulation of cytoplasmic Cdk1 is associated with cancer growth and survival rate in epithelial ovarian cancer

FNDC3B promotes cell migration and tumor metastasis in hepatocellular carcinoma

SEP enhanced the antitumor activity of 5-fluorouracil by up-regulating NKG2D/MICA and reversed immune suppression via inhibiting ROS and caspase-3 in mice

The anti-cancer activity of the mTORC1/2 dual inhibitor XL388 in preclinical osteosarcoma models

Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers

Autocrine glutamatergic transmission for the regulation of embryonal carcinoma stem cells

Clinical significance and diagnostic value of serum CEA, CA19-9 and CA72-4 in patients with gastric cancer

Low level phosphorylation of histone H2AX on serine 139 (γH2AX) is not associated with DNA double-strand breaks

Triptolide inhibits cell growth and GRP78 protein expression but induces cell apoptosis in original and radioresistant NPC cells

Reactivation of ERK and Akt confers resistance of mutant BRAF colon cancer cells to the HSP90 inhibitor AUY922

Transcriptome-wide characterization of the endogenous miR-34A-p53 tumor suppressor network

In-depth proteomic profiling of the uveal melanoma secretome

Metformin as a new anti-cancer drug in adrenocortical carcinoma

Targeting of RET oncogene by naphthalene diimide-mediated gene promoter G-quadruplex stabilization exerts anti-tumor activity in oncogene-addicted human medullary thyroid cancer

P2X7 targeting inhibits growth of human mesothelioma

The “melanoma-enriched” microRNA miR-4731-5p acts as a tumour suppressor

Long non-coding RNA-MIAT promotes neurovascular remodeling in the eye and brain

Dasatinib-loaded albumin nanoparticles possess diminished endothelial cell barrier disruption and retain potent anti-leukemia cell activity

Increasing sensitivity to DNA damage is a potential driver for human ovarian cancer

High CRLF2 expression associates with IKZF1 dysfunction in adult acute lymphoblastic leukemia without CRLF2 rearrangement

Targeting FGFR1 to suppress leukemogenesis in syndromic and de novo AML in murine models

Elevated expression of the IGF2 mRNA binding protein 2 (IGF2BP2/IMP2) is linked to short survival and metastasis in esophageal adenocarcinoma

Novel ERα positive breast cancer model with estrogen independent growth in the bone microenvironment

Prediction of early hepatocellular carcinoma recurrence using germinal center kinase-like kinase

A novel isoflavone, ME-344, targets the cytoskeleton in acute myeloid leukemia

FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes

High expression of WISP1 in colon cancer is associated with apoptosis, invasion and poor prognosis

Histone deacetylase inhibitors regulate P-gp expression in colorectal cancer via transcriptional activation and mRNA stabilization

The miR-644a/CTBP1/p53 axis suppresses drug resistance by simultaneous inhibition of cell survival and epithelial-mesenchymal transition in breast cancer

Clinicopathological and prognostic significance of platelet to lymphocyte ratio in patients with gastric cancer

Elevated expression of eukaryotic translation initiation factor 3H is associated with proliferation, invasion and tumorigenicity in human hepatocellular carcinoma

Targeting the WEE1 kinase as a molecular targeted therapy for gastric cancer

Comprehensive analysis of lncRNAs microarray profile and mRNA–lncRNA co-expression in oncogenic HPV-positive cervical cancer cell lines

Thyroid functional parameters and correlative autoantibodies as prognostic factors for differentiated thyroid cancers

What might explain deprivation-specific differences in the excess hazard of breast cancer death amongst screen-detected women? Analysis of patients diagnosed in the West Midlands region of England from 1989 to 2011

Long non-coding RNA BC087858 induces non-T790M mutation acquired resistance to EGFR-TKIs by activating PI3K/AKT and MEK/ERK pathways and EMT in non-small-cell lung cancer

Docosahexaenoic acid suppresses breast cancer cell metastasis by targeting matrix-metalloproteinases

Antibody neutralization of cell-surface gC1qR/HABP1/SF2-p32 prevents lamellipodia formation and tumorigenesis

Transcriptomic reappraisal identifies MGLL overexpression as an unfavorable prognosticator in primary gastrointestinal stromal tumors

AHNAK enables mammary carcinoma cells to produce extracellular vesicles that increase neighboring fibroblast cell motility

Increased expression of MUC3A is associated with poor prognosis in localized clear-cell renal cell carcinoma

Targeting synthetic lethality between the SRC kinase and the EPHB6 receptor may benefit cancer treatment

Plasticity of lung cancer stem-like cells is regulated by the transcription factor HOXA5 that is induced by oxidative stress

Extracellular translationally controlled tumor protein promotes colorectal cancer invasion and metastasis through Cdc42/JNK/ MMP9 signaling

ASC contributes to metastasis of oral cavity squamous cell carcinoma

Exosomes from human colorectal cancer induce a tumor-like behavior in colonic mesenchymal stromal cells

Class A1 scavenger receptor modulates glioma progression by regulating M2-like tumor-associated macrophage polarization

Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway

Inflammatory related gene IKKα, IKKβ, IKKγ cooperates to determine liver cancer stem cells progression by altering telomere via heterochromatin protein 1-HOTAIR axis

Evaluation of the risk of lymphomagenesis in xenografts by the PCR-based detection of EBV BamHI W region in patient cancer specimens

Acquired nintedanib resistance in FGFR1-driven small cell lung cancer: role of endothelin-A receptor-activated ABCB1 expression

Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner

SIRT1 and LSD1 competitively regulate KU70 functions in DNA repair and mutation acquisition in cancer cells

Mitotic p21^Cip1/CDKN1A is regulated by cyclin-dependent kinase 1 phosphorylation

miR-29c contribute to glioma cells temozolomide sensitivity by targeting O⁶-methylguanine-DNA methyltransferases indirectly

High expression of MnSOD promotes survival of circulating breast cancer cells and increases their resistance to doxorubicin

Compounds from the marine sponge Cribrochalina vasculum offer a way to target IGF-1R mediated signaling in tumor cells

Sunitinib enhances the antitumor responses of agonistic CD40-antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment

Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer

Halofuginone and artemisinin synergistically arrest cancer cells at the G1/G0 phase by upregulating p21^Cip1 and p27^Kip1

TMPRSS4 induces invasion and proliferation of prostate cancer cells through induction of Slug and cyclin D1

5-FU targets rpL3 to induce mitochondrial apoptosis via cystathionine-β-synthase in colon cancer cells lacking p53

TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells

Microvesicle removal of anticancer drugs contributes to drug resistance in human pancreatic cancer cells

Optogenetic regulation of site-specific subtelomeric DNA methylation

A novel pathogenic large germline deletion in adenomatous polyposis coli gene in a Chinese family with familial adenomatous polyposis

Inhibition of canonical WNT/β-catenin signaling is involved in leflunomide (LEF)-mediated cytotoxic effects on renal carcinoma cells

HMGB1 overexpression as a prognostic factor for survival in cancer: a meta-analysis and systematic review

Long non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer

Notch pathway activation is essential for maintenance of stem-like cells in early tongue cancer

High intensity focused ultrasound inhibits melanoma cell migration and metastasis through attenuating microRNA-21-mediated PTEN suppression

Salinomycin co-treatment enhances tamoxifen cytotoxicity in luminal A breast tumor cells by facilitating lysosomal degradation of receptor tyrosine kinases

Comprehensive profiling and quantitation of oncogenic mutations in non small-cell lung carcinoma using single molecule amplification and re-sequencing technology

Myotubularin-related protein 7 inhibits insulin signaling in colorectal cancer

Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer

SUMOylation of PES1 upregulates its stability and function via inhibiting its ubiquitination

Branched multipeptide immunotherapy for glioblastoma using human leukocyte antigen-A*0201-restricted cytotoxic T-lymphocyte epitopes from ERBB2, BIRC5 and CD99

Stress-induced phosphoprotein-1 maintains the stability of JAK2 in cancer cells

TREM-1 expression in craniopharyngioma and Rathke’s cleft cyst: its possible implication for controversial pathology

Cetuximab response in CRC patient-derived xenografts seems predicted by an expression based RAS pathway signature

Panels of tumor-derived RNA markers in peripheral blood of patients with non-small cell lung cancer: their dependence on age, gender and clinical stages

Cambogin exerts anti-proliferative and pro-apoptotic effects on breast adenocarcinoma through the induction of NADPH oxidase 1 and the alteration of mitochondrial morphology and dynamics

Phase II study of neoadjuvant therapy with nab-paclitaxel and cisplatin followed by surgery in patients with locally advanced esophageal squamous cell carcinoma

Clinical factors that influence the outcome of selective devascularization in the treatment of portal hypertension

Outcomes of re-treatment with first-line trastuzumab plus a taxane in HER2 positive metastatic breast cancer patients after (neo)adjuvant trastuzumab: A prospective multicenter study

Efficacy of trastuzumab beyond progression in HER2 positive advanced gastric cancer: a multicenter prospective observational cohort study

The signaling involved in autophagy machinery in keratinocytes and therapeutic approaches for skin diseases

The emerging roles of exosomes in leukemogeneis

Molecular factors in migraine

SETD2: an epigenetic modifier with tumor suppressor functionality

Targeting tumor-associated macrophages to combat pancreatic cancer

The retinal determination gene network: from developmental regulator to cancer therapeutic target

The inflammasome: an emerging therapeutic oncotarget for cancer prevention

Current relevance of hypoxia in head and neck cancer

mTOR: An attractive therapeutic target for osteosarcoma?