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γKlotho is a Novel Marker and Cell Survival Factor in a Subset of Triple Negative Breast Cancers. Cover art by J. Weon, See Trošt et al.
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Table of Contents
Research Perspectives
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| Click chemistry 3Dprinting and omics: the future of drug development |
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https://doi.org/10.18632/oncotarget.6787
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| 2155-2158 |
Priority Research Papers
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| Oncogenic KRAS activates an embryonic stem celllike program in human colon cancer initiation |
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https://doi.org/10.18632/oncotarget.6818
|
| 2159-2174 |
Research Papers: Gerotarget (Focus on Aging)
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| Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1 |
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https://doi.org/10.18632/oncotarget.6814
|
| 2175-2188 |
Research Papers: Pathology
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| Nucleus pulposus phenotypic markers to determine stem cell differentiation: fact or fiction |
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https://doi.org/10.18632/oncotarget.6782
|
| 2189-2200 |
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| MiRNA133b promotes the proliferation of human Sertoli cells through targeting GLI3 |
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https://doi.org/10.18632/oncotarget.6876
|
| 2201-2219 |
Research Papers: Immunology
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| Increased serum NKG2Dligands and downregulation of NKG2D in peripheral blood NK cells of patients with major burns |
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https://doi.org/10.18632/oncotarget.6789
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| 2220-2228 |
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| Chicoric acid binds to two sites and decreases the activity of the YopH bacterial virulence factor |
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https://doi.org/10.18632/oncotarget.6812
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| 2229-2238 |
Research Papers: Autophagy and Cell Death
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| Caspase inhibition impaired the neural stem/progenitor cell response after cortical ischemia in mice |
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https://doi.org/10.18632/oncotarget.6803
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| 2239-2248 |
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| VDAC3 as a sensor of oxidative state of the intermembrane space of mitochondria: the putative role of cysteine residue modifications |
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https://doi.org/10.18632/oncotarget.6850
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| 2249-2268 |
Research Papers: Chromosome
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| Pololike kinase 1 mediates BRCA1 phosphorylation and recruitment at DNA doublestrand breaks |
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https://doi.org/10.18632/oncotarget.6825
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| 2269-2283 |
Reviews
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| EZH2 in normal hematopoiesis and hematological malignancies |
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https://doi.org/10.18632/oncotarget.6198
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| 2284-2296 |
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| MEF2 transcription factors: developmental regulators and emerging cancer genes |
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https://doi.org/10.18632/oncotarget.6223
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| 2297-2312 |
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| Bevacizumab and radiotherapy for the treatment of glioblastoma: brothers in arms or unholy alliance |
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https://doi.org/10.18632/oncotarget.6320
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| 2313-2328 |
Research Papers
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| The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and EµMYC driven Bcell lymphoma |
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https://doi.org/10.18632/oncotarget.4919
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| 2329-2342 |
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| Therapeutic potential of targeting cell division cycle associated 5 for oral squamous cell carcinoma |
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https://doi.org/10.18632/oncotarget.6148
|
| 2343-2353 |
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| Overexpression of TREM2 enhances glioma cell proliferation and invasion: a therapeutic target in human glioma |
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https://doi.org/10.18632/oncotarget.6221
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| 2354-2366 |
|
| Disentangling the microRNA regulatory milieu in multiple myeloma: integrative genomics analysis outlines mixed miRNATF circuits and pathwayderived networks modulated in t4;14 patients |
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https://doi.org/10.18632/oncotarget.6151
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| 2367-2378 |
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| Transcription factor LSF TFCP2 inhibits melanoma growth |
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https://doi.org/10.18632/oncotarget.6230
|
| 2379-2390 |
|
| Inhibition of the miR155 target NIAM phenocopies the growth promoting effect of miR155 in Bcell lymphoma |
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https://doi.org/10.18632/oncotarget.6165
|
| 2391-2400 |
|
| Prognostic impact of concurrent MYC and BCL6 rearrangements and expression in de novo diffuse large Bcell lymphoma |
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https://doi.org/10.18632/oncotarget.6262
|
| 2401-2416 |
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| MicroRNA7085p acts as a therapeutic agent against metastatic lung cancer |
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https://doi.org/10.18632/oncotarget.6594
|
| 2417-2432 |
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| BRCA1/2 mutations perturb telomere biology: characterization of structural and functional abnormalities in vitro and in vivo |
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https://doi.org/10.18632/oncotarget.5693
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| 2433-2454 |
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| Transforming growth factorβ1 polymorphisms and graftversushost disease risk: a metaanalysis |
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https://doi.org/10.18632/oncotarget.6289
|
| 2455-2461 |
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| Suppression of BRD4 inhibits human hepatocellular carcinoma by repressing MYC and enhancing BIM expression |
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https://doi.org/10.18632/oncotarget.6275
|
| 2462-2474 |
|
| NOVA1 inhibition by miR146b5p in the remnant tissue microenvironment defines occult residual disease after gastric cancer removal |
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https://doi.org/10.18632/oncotarget.6542
|
| 2475-2495 |
|
| Adoptive immunotherapy using T lymphocytes redirected to glypican3 for the treatment of lung squamous cell carcinoma |
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https://doi.org/10.18632/oncotarget.6595
|
| 2496-2507 |
|
| Tumorassociated fibroblastconditioned medium induces CDDP resistance in HNSCC cells |
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https://doi.org/10.18632/oncotarget.6210
|
| 2508-2518 |
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| LKB1 promotes cell survival by modulating TIFIAmediated preribosomal RNA synthesis under uridine downregulated conditions |
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https://doi.org/10.18632/oncotarget.6224
|
| 2519-2531 |
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| Simvastatininduced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway |
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https://doi.org/10.18632/oncotarget.6304
|
| 2532-2544 |
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| Concomitant BET and MAPK blockade for effective treatment of ovarian cancer |
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https://doi.org/10.18632/oncotarget.6309
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| 2545-2554 |
|
| Computational selection of antibodydrug conjugate targets for breast cancer |
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https://doi.org/10.18632/oncotarget.6679
|
| 2555-2571 |
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| Tie2 regulates the stemness and metastatic properties of prostate cancer cells |
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https://doi.org/10.18632/oncotarget.3950
|
| 2572-2584 |
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| Overexpression of ATP1B1 predicts an adverse prognosis in cytogenetically normal acute myeloid leukemia |
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https://doi.org/10.18632/oncotarget.6226
|
| 2585-2595 |
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| An integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiation |
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https://doi.org/10.18632/oncotarget.6354
|
| 2596-2610 |
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| γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancers |
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https://doi.org/10.18632/oncotarget.6006
|
| 2611-2628 |
|
| Novel variants in MLL confer to bladder cancer recurrence identified by wholeexome sequencing |
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https://doi.org/10.18632/oncotarget.6380
|
| 2629-2645 |
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| pERK/pAkt phenotyping in circulating tumor cells as a biomarker for sorafenib efficacy in patients with advanced hepatocellular carcinoma |
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https://doi.org/10.18632/oncotarget.6104
|
| 2646-2659 |
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| MicroRNA497 inhibits tumor growth and increases chemosensitivity to 5fluorouracil treatment by targeting KSR1 |
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https://doi.org/10.18632/oncotarget.6545
|
| 2660-2671 |
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| miR192 a prognostic indicator targets the SLC39A6/SNAIL pathway to reduce tumor metastasis in human hepatocellular carcinoma |
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https://doi.org/10.18632/oncotarget.6603
|
| 2672-2683 |
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| STBHO a novel mica fine particle inhibits the teratomaforming ability of human embryonic stem cells after in vivo transplantation |
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https://doi.org/10.18632/oncotarget.6472
|
| 2684-2695 |
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| Mutations in epigenetic regulators are involved in acute lymphoblastic leukemia relapse following allogeneic hematopoietic stem cell transplantation |
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https://doi.org/10.18632/oncotarget.6259
|
| 2696-2708 |
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| microRNA3425p and miR608 inhibit colon cancer tumorigenesis by targeting NAA10 |
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https://doi.org/10.18632/oncotarget.6458
|
| 2709-2720 |
|
| The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia |
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https://doi.org/10.18632/oncotarget.5436
|
| 2721-2733 |
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| Combinatorial drug screening and molecular profiling reveal diverse mechanisms of intrinsic and adaptive resistance to BRAF inhibition in V600E BRAF mutant melanomas |
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https://doi.org/10.18632/oncotarget.6548
|
| 2734-2753 |
|
| An epigenetic biomarker combination of PCDH17 and POU4F2 detects bladder cancer accurately by methylation analyses of urine sediment DNA in Han Chinese |
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https://doi.org/10.18632/oncotarget.6666
|
| 2754-2764 |
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| Ibrutinib synergizes with polyADPribose glycohydrolase inhibitors to induce cell death in AML cells via a BTKindependent mechanism |
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https://doi.org/10.18632/oncotarget.6409
|
| 2765-2779 |
|
| In silico pathway analysis in cervical carcinoma reveals potential new targets for treatment |
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https://doi.org/10.18632/oncotarget.6667
|
| 2780-2795 |
|
| Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic antitumor effects in vitro and in vivo |
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https://doi.org/10.18632/oncotarget.6425
|
| 2796-2808 |
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| Ulocuplumab BMS936564 / MDX1338: a fully human antiCXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen speciesdependent pathway |
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https://doi.org/10.18632/oncotarget.6465
|
| 2809-2822 |
|
| UBE4B targets phosphorylated p53 at serines 15 and 392 for degradation |
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https://doi.org/10.18632/oncotarget.6555
|
| 2823-2836 |
|
| Interferonγinduced p27KIP1 binds to and targets MYC for proteasomemediated degradation |
|
https://doi.org/10.18632/oncotarget.6693
|
| 2837-2854 |
|
| Biocompatible and colloidally stabilized mPEGPE/calcium phosphate hybrid nanoparticles loaded with siRNAs targeting tumors |
|
https://doi.org/10.18632/oncotarget.6428
|
| 2855-2866 |
|
| Inferring the progression of multifocal liver cancer from spatial and temporal genomic heterogeneity |
|
https://doi.org/10.18632/oncotarget.6558
|
| 2867-2877 |
|
| TLE4 promotes colorectal cancer progression through activation of JNK/cJun signaling pathway |
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https://doi.org/10.18632/oncotarget.6694
|
| 2878-2888 |
|
| Oncogene and drug resistanceassociated alternative exon usage in acute myeloid leukemia AML |
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https://doi.org/10.18632/oncotarget.3898
|
| 2889-2909 |
|
| Inhibition of the pentose phosphate pathway by dichloroacetate unravels a missing link between aerobic glycolysis and cancer cell proliferation |
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https://doi.org/10.18632/oncotarget.6272
|
| 2910-2920 |
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| The erbB3 and IGF1 receptorinitiated signaling pathways exhibit distinct effects on lapatinib sensitivity against trastuzumabresistant breast cancer cells |
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https://doi.org/10.18632/oncotarget.6404
|
| 2921-2935 |
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| The Tolllike receptor 5 agonist entolimod suppresses hepatic metastases in a murine model of ocular melanoma via an NK celldependent mechanism |
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https://doi.org/10.18632/oncotarget.6500
|
| 2936-2950 |
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| Expression and function of lysophosphatidic acid receptors LPARs 1 and 3 in human hepatic cancer progenitor cells |
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https://doi.org/10.18632/oncotarget.6696
|
| 2951-2967 |
|
| Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model |
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https://doi.org/10.18632/oncotarget.6502
|
| 2968-2984 |
|
| Melatonin inhibits AP2β/hTERT NFκB/COX2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells |
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https://doi.org/10.18632/oncotarget.6407
|
| 2985-3001 |
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| Towards understanding the breast cancer epigenome: a comparison of genomewide DNA methylation and gene expression data |
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https://doi.org/10.18632/oncotarget.6503
|
| 3002-3017 |
|
| NDN is an imprinted tumor suppressor gene that is downregulated in ovarian cancers through genetic and epigenetic mechanisms |
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https://doi.org/10.18632/oncotarget.6576
|
| 3018-3032 |
|
| Novel evidence that pituitary gonadotropins directly stimulate human leukemic cellsstudies of myeloid cell lines and primary patient AML and CML cells |
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https://doi.org/10.18632/oncotarget.6698
|
| 3033-3046 |
|
| miR16 targets fibroblast growth factor 2 to inhibit NPC cell proliferation and invasion via PI3K/AKT and MAPK signaling pathways |
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https://doi.org/10.18632/oncotarget.6504
|
| 3047-3058 |
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| Intraoperative imaging identifies thymoma margins following neoadjuvant chemotherapy |
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https://doi.org/10.18632/oncotarget.6578
|
| 3059-3067 |
|
| Identification of a novel HER3 activating mutation homologous to EGFRL858R in lung cancer |
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https://doi.org/10.18632/oncotarget.6585
|
| 3068-3083 |
|
| Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugs |
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https://doi.org/10.18632/oncotarget.6413
|
| 3084-3097 |
|
| AnnexinA1 and caldesmon are associated with resistance to tamoxifen in estrogen receptor positive recurrent breast cancer |
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https://doi.org/10.18632/oncotarget.6521
|
| 3098-3110 |
|
| Oxidative stress induces the acquisition of cancer stemlike phenotype in breast cancer detectable by using a Sox2 regulatory region2 SRR2 reporter |
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https://doi.org/10.18632/oncotarget.6630
|
| 3111-3127 |
|
| Tumor suppressor BTG1 promotes PRMT1mediated ATF4 function in response to cellular stress |
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https://doi.org/10.18632/oncotarget.6519
|
| 3128-3143 |
|
| A novel PAD4/SOX4/PU1 signaling pathway is involved in the committed differentiation of acute promyelocytic leukemia cells into granulocytic cells |
|
https://doi.org/10.18632/oncotarget.6551
|
| 3144-3157 |
|
| Mps1 is SUMOmodified during the cell cycle |
|
https://doi.org/10.18632/oncotarget.6552
|
| 3158-3170 |
|
| Antibiotic drug tigecycline inhibits melanoma progression and metastasis in a p21CIP1/Waf1dependent manner |
|
https://doi.org/10.18632/oncotarget.6419
|
| 3171-3185 |
|
| Combination of Tolfenamic acid and curcumin induces colon cancer cell growth inhibition through modulating specific transcription factors and reactive oxygen species |
|
https://doi.org/10.18632/oncotarget.6553
|
| 3186-3200 |
|
| Luminal long noncoding RNAs regulated by estrogen receptor alpha in a ligandindependent manner show functional roles in breast cancer |
|
https://doi.org/10.18632/oncotarget.6420
|
| 3201-3216 |
|
| Quinomycin A targets Notch signaling pathway in pancreatic cancer stem cells |
|
https://doi.org/10.18632/oncotarget.6560
|
| 3217-3232 |
|
| Sphingosine kinase 1 is overexpressed and promotes adrenocortical carcinoma progression |
|
https://doi.org/10.18632/oncotarget.6564
|
| 3233-3244 |
|
| A chemotherapy response classifier based on support vector machines for highgrade serous ovarian carcinoma |
|
https://doi.org/10.18632/oncotarget.6569
|
| 3245-3254 |
|
| Direct quantitative detection for cellfree miR155 in urine: a potential role in diagnosis and prognosis for nonmuscle invasive bladder cancer |
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https://doi.org/10.18632/oncotarget.6487
|
| 3255-3266 |
|
| Artemin is hypoxia responsive and promotes oncogenicity and increased tumor initiating capacity in hepatocellular carcinoma |
|
https://doi.org/10.18632/oncotarget.6572
|
| 3267-3282 |
|
| Tumor suppressor REIC/DKK3 and cochaperone SGTA: Their interaction and roles in the androgen sensitivity |
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https://doi.org/10.18632/oncotarget.6488
|
| 3283-3296 |
|
| Unique roles of Akt1 and Akt2 in IGFIR mediated lung tumorigenesis |
|
https://doi.org/10.18632/oncotarget.6489
|
| 3297-3316 |
|
| Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma |
|
https://doi.org/10.18632/oncotarget.6580
|
| 3317-3331 |
|
| Prognostic significance of FAM83D gene expression across human cancer types |
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https://doi.org/10.18632/oncotarget.6620
|
| 3332-3340 |
|
| Inhibition of hypoxia inducible factor 1 and topoisomerase with acriflavine sensitizes perihilar cholangiocarcinomas to photodynamic therapy |
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https://doi.org/10.18632/oncotarget.6490
|
| 3341-3356 |
|
| Detection of EpCAMpositive microparticles in pleural fluid: A new approach to miniinvasively identify patients with malignant pleural effusions |
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https://doi.org/10.18632/oncotarget.6581
|
| 3357-3366 |
|
| EGFR kinase domain mutation positive lung cancers are sensitive to intrapleural perfusion with hyperthermic chemotherapy IPHC complete treatment |
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https://doi.org/10.18632/oncotarget.6491
|
| 3367-3378 |
|
| Monoamine oxidase B levels are highly expressed in human gliomas and are correlated with the expression of HiF1α and with transcription factors Sp1 and Sp3 |
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https://doi.org/10.18632/oncotarget.6582
|
| 3379-3393 |
|
| Regulatory T cells may participate in Helicobacter pylori persistence in gastric MALT lymphoma: lessons from an animal model |
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https://doi.org/10.18632/oncotarget.6492
|
| 3394-3402 |
|
| Mutational landscape of MCPyVpositive and MCPyVnegative Merkel cell carcinomas with implications for immunotherapy |
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https://doi.org/10.18632/oncotarget.6494
|
| 3403-3415 |
|
| Involvement of Nrf2 in proteasome inhibitionmediated induction of ORP150 in thyroid cancer cells |
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https://doi.org/10.18632/oncotarget.6636
|
| 3416-3426 |
|
| Obglike ATPase 1 regulates global protein serine/threonine phosphorylation in cancer cells by suppressing the GSK3βinhibitor 2PP1 positive feedback loop |
|
https://doi.org/10.18632/oncotarget.6496
|
| 3427-3439 |
|
| Inhibition of EZH2 by chemo and radiotherapy agents and small molecule inhibitors induces cell death in castrationresistant prostate cancer |
|
https://doi.org/10.18632/oncotarget.6497
|
| 3440-3452 |
|
| HER2 genomic amplification in circulating tumor DNA from patients with cetuximabresistant colorectal cancer |
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https://doi.org/10.18632/oncotarget.6498
|
| 3453-3460 |
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| Molecular evidence of Zn chelation of the procaspase activating compound BPAC1 in B cell lymphoma |
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https://doi.org/10.18632/oncotarget.6505
|
| 3461-3476 |
|
| The positive prognostic effect of stromal CD8+ tumorinfiltrating T cells is restrained by the expression of HLAE in nonsmall cell lung carcinoma |
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https://doi.org/10.18632/oncotarget.6506
|
| 3477-3488 |
|
| Chronic ethanol exposure enhances the aggressiveness of breast cancer: the role of p38γ |
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https://doi.org/10.18632/oncotarget.6508
|
| 3489-3505 |
|
| FOXP1 functions as an oncogene in promoting cancer stem celllike characteristics in ovarian cancer cells |
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https://doi.org/10.18632/oncotarget.6510
|
| 3506-3519 |
|
| Selective targeting of BCL6 induces oncogene addiction switching to BCL2 in Bcell lymphoma |
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https://doi.org/10.18632/oncotarget.6513
|
| 3520-3532 |
|
| Gamabufotalin a major derivative of bufadienolide inhibits VEGFinduced angiogenesis by suppressing VEGFR2 signaling pathway |
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https://doi.org/10.18632/oncotarget.6514
|
| 3533-3547 |
|
| Auranofinmediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in nonsmall cell lung cancer cells |
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https://doi.org/10.18632/oncotarget.6516
|
| 3548-3558 |
|
| Mitochondrial reactive oxygen species perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of PP2A in lowdose irradiated human fibroblasts |
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https://doi.org/10.18632/oncotarget.6518
|
| 3559-3570 |
|
| Metronomic topotecan impedes tumor growth of MYCNamplified neuroblastoma cells in vitro and in vivo by therapy induced senescence |
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https://doi.org/10.18632/oncotarget.6527
|
| 3571-3586 |
|
| A microRNAbased prediction model for lymph node metastasis in hepatocellular carcinoma |
|
https://doi.org/10.18632/oncotarget.6534
|
| 3587-3598 |
Clinical Research Papers
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| Mutually exclusive mutations in NOTCH1 and PIK3CA associated with clinical prognosis and chemotherapy responses of esophageal squamous cell carcinoma in China |
|
https://doi.org/10.18632/oncotarget.6120
|
| 3599-3613 |
|
| Tolerability and efficacy of gamma knife radiosurgery on hepatocellular carcinoma with portal vein tumor thrombosis |
|
https://doi.org/10.18632/oncotarget.6118
|
| 3614-3622 |
|
| HAG regimen improves survival in adult patients with hypocellular acute myeloid leukemia |
|
https://doi.org/10.18632/oncotarget.6211
|
| 3623-3634 |
|
| Greater efficacy of chemotherapy plus bevacizumab compared to chemo and targeted therapy alone on nonsmall cell lung cancer patients with brain metastasis |
|
https://doi.org/10.18632/oncotarget.6184
|
| 3635-3644 |
|
| Development of a tensignature classifier using a support vector machine integrated approach to subdivide the M1 stage into M1a and M1b stages of nasopharyngeal carcinoma with synchronous metastases to better predict patients’ survival |
|
https://doi.org/10.18632/oncotarget.6436
|
| 3645-3657 |
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