Epidermal Nbn deletion causes premature hair loss and a phenotype resembling psoriasiform dermatitis

Adipose triglyceride lipase decrement affects skeletal muscle homeostasis during aging through FAs-PPARα-PGC-1α antioxidant response

Nitrogen and carbon source balance determines longevity, independently of fermentative or respiratory metabolism in the yeast Saccharomyces cerevisiae

Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health

The pathological role of advanced glycation end products-downregulated heat shock protein 60 in islet β-cell hypertrophy and dysfunction

Effect of CTLA-4 gene polymorphisms on long-term kidney allograft function in Han Chinese recipients

Does an NKT-cell-based immunotherapeutic approach have a future in multiple myeloma?

The altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters

hsa-miR-9 controls the mobility behavior of glioblastoma cells via regulation of MAPK14 signaling elements

MRP1-CD28 bi-specific oligonucleotide aptamers: target costimulation to drug-resistant melanoma cancer stem cells

STARD13-correlated ceRNA network inhibits EMT and metastasis of breast cancer

E2F1-induced upregulation of long noncoding RNA LINC00668 predicts a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically silencing of CKIs

Advanced malignancies treated with a combination of the VEGF inhibitor bevacizumab, anti-EGFR antibody cetuximab, and the mTOR inhibitor temsirolimus

Emetine induces chemosensitivity and reduces clonogenicity of acute myeloid leukemia cells

Concordance of anaplastic lymphoma kinase (ALK) gene rearrangements between circulating tumor cells and tumor in non-small cell lung cancer

Meta-analysis of transcriptome data identifies a novel 5-gene pancreatic adenocarcinoma classifier

Depletion of FAP+ cells reduces immunosuppressive cells and improves metabolism and functions CD8+T cells within tumors

MAPK1^E322K mutation increases head and neck squamous cell carcinoma sensitivity to erlotinib through enhanced secretion of amphiregulin

Genomic landscape of DNA repair genes in cancer

β-casein nanovehicles for oral delivery of chemotherapeutic drug combinations overcoming P-glycoprotein-mediated multidrug resistance in human gastric cancer cells

Identification of extracellular vesicle-borne periostin as a feature of muscle-invasive bladder cancer

Hepatitis B virus PreS2-mutant large surface antigen activates store-operated calcium entry and promotes chromosome instability

Near infrared photoimmunotherapy with an anti-mesothelin antibody

BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death

Cell fate determination in cisplatin resistance and chemosensitization

NF-κB functions as a molecular link between tumor cells and Th1/Tc1 T cells in the tumor microenvironment to exert radiation-mediated tumor suppression

ABCG1 maintains high-grade glioma survival in vitro and in vivo

Tumor growth suppressive effect of IL-4 through p21-mediated activation of STAT6 in IL-4Rα overexpressed melanoma models

BCL6 modulation of acute lymphoblastic leukemia response to chemotherapy

Genomic portfolio of Merkel cell carcinoma as determined by comprehensive genomic profiling: implications for targeted therapeutics

Activation of autophagy flux by metformin downregulates cellular FLICE–like inhibitory protein and enhances TRAIL- induced apoptosis

Role of ADAM17 in invasion and migration of CD133-expressing liver cancer stem cells after irradiation

Androgen deprivation therapy sensitizes triple negative breast cancer cells to immune-mediated lysis through androgen receptor independent modulation of osteoprotegerin

Increased chemoresistance via Snail–Raf kinase inhibitor protein signaling in colorectal cancer in response to a nicotine derivative

Driver or passenger effects of augmented c-Myc and Cdc20 in gliomagenesis

GP73 N-glycosylation at Asn144 reduces hepatocellular carcinoma cell motility and invasiveness

Effect of sorafenib on cisplatin-based chemoradiation in head and neck cancer cells

Krüppel-like factor 8 activates the transcription of C-X-C cytokine receptor type 4 to promote breast cancer cell invasion, transendothelial migration and metastasis

Novel circulating peptide biomarkers for esophageal squamous cell carcinoma revealed by a magnetic bead-based MALDI-TOFMS assay

Progression of benign prostatic hyperplasia is associated with pro-inflammatory mediators and chronic activation of prostate-infiltrating lymphocytes

HER2-siRNA delivered by EGFR-specific single chain antibody inhibits NSCLC cell proliferation and tumor growth

[Pemetrexed + Sorafenib] lethality is increased by inhibition of ERBB1/2/3-PI3K-NFκB compensatory survival signaling

The mTOR inhibitor Everolimus synergizes with the PI3K inhibitor GDC0941 to enhance anti-tumor efficacy in uveal melanoma

Associations between serum CA724 and HER2 overexpression among stage II–III resectable gastric cancer patients: an observational study

Toll-like receptors 1, 2, 4 and 6 in esophageal epithelium, Barrett’s esophagus, dysplasia and adenocarcinoma

MicroRNA-16 sensitizes breast cancer cells to paclitaxel through suppression of IKBKB expression

Escin Ia suppresses the metastasis of triple-negative breast cancer by inhibiting epithelial-mesenchymal transition via down-regulating LOXL2 expression

SNP-SNP interactions of three new pri-miRNAs with the target gene PGC and multidimensional analysis of H. pylori in the gastric cancer/atrophic gastritis risk in a Chinese population

TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors

Dormancy activation mechanism of tracheal stem cells

The DEK oncogene activates VEGF expression and promotes tumor angiogenesis and growth in HIF-1α-dependent and -independent manners

Upregulation of E2F8 promotes cell proliferation and tumorigenicity in breast cancer by modulating G1/S phase transition

Virtual screening-driven repositioning of etoposide as CD44 antagonist in breast cancer cells

Activation of TRPV2 and BKCa channels by the LL-37 enantiomers stimulates calcium entry and migration of cancer cells

Hypoxia-regulated gene expression explains differences between melanoma cell line-derived xenografts and patient-derived xenografts

The NEDD8-activating enzyme inhibitor MLN4924 induces G2 arrest and apoptosis in T-cell acute lymphoblastic leukemia

Two classes of intrahepatic cholangiocarcinoma defined by relative abundance of mutations and copy number alterations

PIM1 destabilization activates a p53-dependent response to ribosomal stress in cancer cells

Rnf25/AO7 positively regulates wnt signaling via disrupting Nkd1-Axin inhibitory complex independent of its ubiquitin ligase activity

IMB-6G, a novel N-substituted sophoridinic acid derivative, induces endoplasmic reticulum stress-mediated apoptosis via activation of IRE1α and PERK signaling

Clinicopathologic characteristics of EGFR, KRAS, and ALK alterations in 6,595 lung cancers

Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation

Integrated analysis of long non-coding RNAs in human colorectal cancer

High expression of C-C chemokine receptor 2 associates with poor overall survival in gastric cancer patients after surgical resection

Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth

Triptolide has anticancer and chemosensitization effects by down-regulating Akt activation through the MDM2/REST pathway in human breast cancer

Role of isoenzyme M2 of pyruvate kinase in urothelial tumorigenesis

Plasminogen activator inhibitor-1 enhances radioresistance and aggressiveness of non-small cell lung cancer cells

Distinct effects of SIRT1 in cancer and stromal cells on tumor promotion

Armored long non-coding RNA MEG3 targeting EGFR based on recombinant MS2 bacteriophage virus-like particles against hepatocellular carcinoma

C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties

Transmembrane adaptor protein PAG1 is a novel tumor suppressor in neuroblastoma

Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells

cRGD inhibits vasculogenic mimicry formation by down-regulating uPA expression and reducing EMT in ovarian cancer

An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2

MicroRNA-1229 overexpression promotes cell proliferation and tumorigenicity and activates Wnt/β-catenin signaling in breast cancer

Prospective phase II trial of pazopanib plus CapeOX (capecitabine and oxaliplatin) in previously untreated patients with advanced gastric cancer

An individualized prognostic signature and multi‑omics distinction for early stage hepatocellular carcinoma patients with surgical resection

Tumor necrosis factor receptor 2-signaling in CD133-expressing cells in renal clear cell carcinoma

Targeting the epigenetic readers in Ewing Sarcoma inhibits the oncogenic transcription factor EWS/Fli1

Phenylethanolamine N-methyltransferase downregulation is associated with malignant pheochromocytoma/paraganglioma

DEPTOR promotes survival of cervical squamous cell carcinoma cells and its silencing induces apoptosis through downregulating PI3K/AKT and by up-regulating p38 MAP kinase

Genomic profiling of lung adenocarcinoma patients reveals therapeutic targets and confers clinical benefit when standard molecular testing is negative

Hedgehog pathway maintains cell survival under stress conditions, and drives drug resistance in lung adenocarcinoma

Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis

Survival analysis of patients with advanced-stage nasopharyngeal carcinoma according to the Epstein-Barr virus status

Predictive value of angiogenesis-related gene profiling in patients with HER2-negative metastatic breast cancer treated with bevacizumab and weekly paclitaxel

mTOR inhibition as an adjuvant therapy in a metastatic model of HPV+ HNSCC

Functional role of eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) in NSCLC

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use

PD-L1 is an independent prognostic predictor in gastric cancer of Western patients

The retinoblastoma protein regulates hypoxia-inducible genetic programs, tumor cell invasiveness and neuroendocrine differentiation in prostate cancer cells

Multilevel induction of apoptosis by microtubule-interfering inhibitors 4β-S-aromatic heterocyclic podophyllum derivatives causing multi-fold mitochondrial depolarization and PKA signaling pathways in HeLa cells

Oncogenic protein SALL4 and ZNF217 as prognostic indicators in solid cancers: a meta‑analysis of individual studies

Genomic and epigenomic analysis of high-risk prostate cancer reveals changes in hydroxymethylation and TET1

Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein

Eukaryotic translation initiation factor 5A2 regulates the migration and invasion of hepatocellular carcinoma cells via pathways involving reactive oxygen species

EGFR mediates hyperlipidemia-induced renal injury via regulating inflammation and oxidative stress: the detrimental role and mechanism of EGFR activation

ANO1 protein as a potential biomarker for esophageal cancer prognosis and precancerous lesion development prediction

Twist1-related miR-26b-5p suppresses epithelial-mesenchymal transition, migration and invasion by targeting SMAD1 in hepatocellular carcinoma

Prevention of cisplatin-based chemotherapy-induced delayed nausea and vomiting using triple antiemetic regimens: a mixed treatment comparison

Functional characterization and anti-cancer action of the clinical phase II cardiac Na⁺/K⁺ ATPase inhibitor istaroxime: in vitro and in vivo properties and cross talk with the membrane androgen receptor

Nimotuzumab combined with concurrent chemoradiotherapy in locally advanced nasopharyngeal carcinoma: a retrospective analysis

BM microenvironmental protection of CML cells from imatinib through Stat5/NF-κB signaling and reversal by Wogonin

Neuropathy correlated with imbalanced Foxp3/IL-17 in bone marrow microenvironment of patients with acute myeloid leukemia

MicroRNA-421 regulated by HIF-1α promotes metastasis, inhibits apoptosis, and induces cisplatin resistance by targeting E-cadherin and caspase-3 in gastric cancer

Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon

Adipose microenvironment promotes triple negative breast cancer cell invasiveness and dissemination by producing CCL5

miR-206 regulates cisplatin resistance and EMT in human lung adenocarcinoma cells partly by targeting MET

Granulocyte macrophage colony-stimulating factor predicts postoperative recurrence of clear-cell renal cell carcinoma

MiR-206 suppresses epithelial mesenchymal transition by targeting TGF-β signaling in estrogen receptor positive breast cancer cells

Prognostic implications of PIK3CA amplification in curatively resected liposarcoma

miR-31 is distinctively overexpressed in primary male extramammary Paget's disease

Chronic inflammation-associated genomic instability paves the way for human esophageal carcinogenesis

Fas-associated protein with death domain (FADD) regulates autophagy through promoting the expression of Ras homolog enriched in brain (Rheb) in human breast adenocarcinoma cells

Exosomes derived from gefitinib-treated EGFR-mutant lung cancer cells alter cisplatin sensitivity via up-regulating autophagy

Analysis of mutational and clinicopathologic characteristics of lung adenocarcinoma with clear cell component

Multifunctional targeting vinorelbine plus tetrandrine liposomes for treating brain glioma along with eliminating glioma stem cells

Proper hepatic pedicle clamping during hepatectomy is associated with improved postoperative long-term prognosis in patients with AJCC stage IIIB hepatocellular carcinoma

Cefradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of T-LAK cell-originated protein kinase

KIF23 is an independent prognostic biomarker in glioma, transcriptionally regulated by TCF-4

Prevalence characteristics of high-risk human papillomaviruses in women living in Shanghai with cervical precancerous lesions and cancer

Altered neutrophil immunophenotypes in childhood B‑cell precursor acute lymphoblastic leukemia

Epithelial-to-mesenchymal transition leads to loss of EpCAM and different physical properties in circulating tumor cells from metastatic breast cancer

Expression of epithelial-mesenchymal transition-related genes increases with copy number in multiple cancer types

Progerin impairs chromosome maintenance by depleting CENP-F from metaphase kinetochores in Hutchinson-Gilford progeria fibroblasts

Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer

The microRNA-124-iGluR2/3 pathway regulates glucagon release from alpha cells

Predictive value of EGFR overexpression and gene amplification on icotinib efficacy in patients with advanced esophageal squamous cell carcinoma

Combination of an anti-EGFRvIII antibody CH12 with Rapamycin synergistically inhibits the growth of EGFRvIII⁺PTEN^–glioblastoma in vivo

A comprehensive repertoire of tRNA-derived fragments in prostate cancer

DNA promoter hypermethylation in nipple fluid: a potential tool for early breast cancer detection

Monocyte chemotactic protein-1 deficiency reduces spontaneous metastasis of Lewis lung carcinoma in mice fed a high-fat diet

Promoter methylation of RNF180 is associated with H.pylori infection and serves as a marker for gastric cancer and atrophic gastritis

The tumor-inhibitory effectiveness of a novel anti-Trop2 Fab conjugate in pancreatic cancer

New insights into the prognostic value of Ki-67 labeling index in patients with triple-negative breast cancer

G protein γ subunit 7 induces autophagy and inhibits cell division

Use of dedicated gene panel sequencing using next generation sequencing to improve the personalized care of lung cancer

Sitagliptin use and thyroid cancer risk in patients with type 2 diabetes

Marital status independently predicts pancreatic cancer survival in patients treated with surgical resection: an analysis of the SEER database

Therapy to target renal cell carcinoma using ¹³¹I-labeled B7-H3 monoclonal antibody