About-face on the metabolic side effects of rapamycin

Antibiotics for cancer therapy

Tumor-targeting Salmonella typhimurium A1-R arrests growth of breast-cancer brain metastasis

Identification of a new class of natural product MDM2 inhibitor: In vitro and in vivo anti-breast cancer activities and target validation

Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to cyclin-dependent kinase inhibitors in leukemia

CBX7 and HMGA1b proteins act in opposite way on the regulation of the SPP1 gene expression

The translation inhibitor silvestrol exhibits direct anti-tumor activity while preserving innate and adaptive immunity against EBV-driven lymphoproliferative disease

A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma

The non glycanated endocan polypeptide slows tumor growth by inducing stromal inflammatory reaction

Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of matrix metalloproteinase-2 and subsequent metastatic ability in human osteosarcomas

Mutational spectrum of adult T-ALL

Reduction of miR-29c enhances pancreatic cancer cell migration and stem cell-like phenotype

Sema6A and Mical1 control cell growth and survival of BRAF^V600E human melanoma cells

Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation

Novel antigens in non-small cell lung cancer: SP17, AKAP4, and PTTG1 are potential immunotherapeutic targets

Folate-mediated mitochondrial targeting with doxorubicin-polyrotaxane nanoparticles overcomes multidrug resistance

MicroRNA 196B regulates FAS-mediated apoptosis in colorectal cancer cells

Chronic inflammation-related DNA damage response: a driving force of gastric cardia carcinogenesis

NCL1, a highly selective lysine-specific demethylase 1 inhibitor, suppresses prostate cancer without adverse effect

12/15 lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12-HETE and 13-HODE in animal models

Statin-induced depletion of geranylgeranyl pyrophosphate inhibits cell proliferation by a novel pathway of Skp2 degradation

Clusterin facilitates metastasis by EIF3I/Akt/MMP13 signaling in hepatocellular carcinoma

Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation

Epigenetic reprogramming by tumor-derived EZH2 gain-of-function mutations promotes aggressive 3D cell morphologies and enhances melanoma tumor growth

Cathelicidin, an antimicrobial peptide produced by macrophages, promotes colon cancer by activating the Wnt/β-catenin pathway

Adhesion glycoprotein CD44 functions as an upstream regulator of a network connecting ERK, AKT and Hippo-YAP pathways in cancer progression

miR-638 promotes melanoma metastasis and protects melanoma cells from apoptosis and autophagy

Active secretion of CXCL10 and CCL5 from colorectal cancer microenvironments associates with GranzymeB+ CD8+ T-cell infiltration

Transcriptional regulation of Sox2 by the retinoblastoma family of pocket proteins

TXNIP interaction with the Her-1/2 pathway contributes to overall survival in breast cancer

Protein arginine methyltransferase 7 promotes breast cancer cell invasion through the induction of MMP9 expression

Cyclin alterations in diverse cancers: Outcome and co-amplification network

Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle

Lovastatin enhances adenovirus-mediated TRAIL induced apoptosis by depleting cholesterol of lipid rafts and affecting CAR and death receptor expression of prostate cancer cells

Long-term treatment with imatinib results in profound mast cell deficiency in Ph+ chronic myeloid leukemia

Paracrine SDF-1α signaling mediates the effects of PSCs on GEM chemoresistance through an IL-6 autocrine loop in pancreatic cancer cells

Molecular chaperone GRP78 enhances aggresome delivery to autophagosomes to promote drug resistance in multiple myeloma

Galectin-1 is overexpressed in CD133⁺ human lung adenocarcinoma cells and promotes their growth and invasiveness

Slit2/Robo1 signaling promotes intestinal tumorigenesis through Src-mediated activation of the Wnt/β-catenin pathway

Top2a identifies and provides epigenetic rationale for novel combination therapeutic strategies for aggressive prostate cancer

Targeting miR-381-NEFL axis sensitizes glioblastoma cells to temozolomide by regulating stemness factors and multidrug resistance factors

Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target

Metformin inhibits tumor growth by regulating multiple miRNAs in human cholangiocarcinoma

Simultaneous targeting of androgen receptor (AR) and MAPK-interacting kinases (MNKs) by novel retinamides inhibits growth of human prostate cancer cell lines

MicroRNA-93 activates c-Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A

Genistein suppresses FLT4 and inhibits human colorectal cancer metastasis

KITENIN promotes glioma invasiveness and progression, associated with the induction of EMT and stemness markers

Dihydromyricetin prevents cardiotoxicity and enhances anticancer activity induced by adriamycin

MiR-125b regulates epithelial-mesenchymal transition via targeting Sema4C in paclitaxel-resistant breast cancer cells

Biomolecular characterization of exosomes released from cancer stem cells: Possible implications for biomarker and treatment of cancer

MYC is a critical target of FBXW7

Overexpression of IFN-induced protein with tetratricopeptide repeats 3 (IFIT3) in pancreatic cancer: cellular “pseudoinflammation” contributing to an aggressive phenotype

In vivo treatment with epigenetic modulating agents induces transcriptional alterations associated with prognosis and immunomodulation in multiple myeloma

Prognostic and therapeutic impact of RPN2-mediated tumor malignancy in non-small-cell lung cancer

Differential expression and prognostic value of the chemokine receptor CXCR4 in bronchopulmonary neuroendocrine neoplasms

Mechanism of action and therapeutic efficacy of Aurora kinase B inhibition in MYC overexpressing medulloblastoma

A Golgi-based KDELR-dependent signalling pathway controls extracellular matrix degradation

Combined inhibition of Chk1 and Wee1 as a new therapeutic strategy for mantle cell lymphoma

FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis

RMP predicts survival and adjuvant TACE response in hepatocellular carcinoma

Oncogenes and tumor suppressor genes in squamous cell carcinoma of the tongue in young patients

B7-H1 and B7-H3 are independent predictors of poor prognosis in patients with non-small cell lung cancer

Potential impact of human papilloma virus on survival of basaloid squamous carcinoma of the head and neck