Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21^WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry

HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells

CSN6 deregulation impairs genome integrity in a COP1-dependent pathway

ERp19 contributes to tumorigenicity in human gastric cancer by promoting cell growth, migration and invasion

Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models

Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition

AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts

RAB7 counteracts PI3K-driven macropinocytosis activated at early stages of melanoma development

c-Jun N-terminal kinase 2 prevents luminal cell commitment in normal mammary glands and tumors by inhibiting p53/Notch1 and breast cancer gene 1 expression

Activation of hypoxia signaling induces phenotypic transformation of glioma cells: implications for bevacizumab antiangiogenic therapy

Meta-analysis of organ-specific differences in the structure of the immune infiltrate in major malignancies

Cripto-1 as a novel therapeutic target for triple negative breast cancer

Aquaporin 1 and 5 expression decreases during human intervertebral disc degeneration: novel HIF-1-mediated regulation of aquaporins in NP cells

Combined effects of aging and inflammation on renin-angiotensin system mediate mitochondrial dysfunction and phenotypic changes in cardiomyopathies

Filamin A phosphorylation by Akt promotes cell migration in response to arsenic

Therapeutic targeting of polo-like kinase 1 using RNA-interfering nanoparticles (iNOPs) for the treatment of non-small cell lung cancer

Epidermal growth factor receptor mutation mediates cross-resistance to panitumumab and cetuximab in gastrointestinal cancer

CXCL12-induced VLA-4 activation is impaired in trisomy 12 chronic lymphocytic leukemia cells: a role for CCL21

TIMP-1 activated carcinoma-associated fibroblasts inhibit tumor apoptosis by activating SDF1/CXCR4 signaling in hepatocellular carcinoma

Differential expression of cell cycle regulators in CDK5-dependent medullary thyroid carcinoma tumorigenesis

From the core to beyond the margin: a genomic picture of glioblastoma intratumor heterogeneity

Comparison of a healthy miRNome with melanoma patient miRNomes: are microRNAs suitable serum biomarkers for cancer?

Discovery of a small molecule targeting SET-PP2A interaction to overcome BCR-ABLT315I mutation of chronic myeloid leukemia

The emerging role of NG2 in pediatric diffuse intrinsic pontine glioma

Tudor staphylococcal nuclease drives chemoresistance of non-small cell lung carcinoma cells by regulating S100A11

Ubiquitin E3 ligase MARCH7 promotes ovarian tumor growth

miR-20b is up-regulated in brain metastases from primary breast cancers

Hepatitis B virus X protein induces expression of alpha-fetoprotein and activates PI3K/mTOR signaling pathway in liver cells

FKBPL: a marker of good prognosis in breast cancer

Identification of a novel TGF-β-miR-122-fibronectin 1/serum response factor signaling cascade and its implication in hepatic fibrogenesis

Multi-platform profiling of over 2000 sarcomas: Identification of biomarkers and novel therapeutic targets

Loss of the N-terminal methyltransferase NRMT1 increases sensitivity to DNA damage and promotes mammary oncogenesis

Estrogen receptor (ER) was regulated by RNPC1 stabilizing mRNA in ER positive breast cancer

Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype

Molecular stratification of metastatic melanoma using gene expression profiling : Prediction of survival outcome and benefit from molecular targeted therapy

Celecoxib increases EGF signaling in colon tumor associated fibroblasts, modulating EGFR expression and degradation

Infiltrated pre-adipocytes increase prostate cancer metastasis via modulation of the miR-301a/androgen receptor (AR)/TGF-β1/Smad/MMP9 signals

Sorafenib and DE605, a novel c-Met inhibitor, synergistically suppress hepatocellular carcinoma

PAQR3 expression is downregulated in human breast cancers and correlated with HER2 expression

Ex vivo generation of myeloid-derived suppressor cells that model the tumor immunosuppressive environment in colorectal cancer

Loss of Wave1 gene defines a subtype of lethal prostate cancer

TOPK is highly expressed in circulating tumor cells, enabling metastasis of prostate cancer

NHE9 induces chemoradiotherapy resistance in esophageal squamous cell carcinoma by upregulating the Src/Akt/β-catenin pathway and Bcl-2 expression

SRC family kinase (SFK) inhibition reduces rhabdomyosarcoma cell growth in vitro and in vivo and triggers p38 MAP kinase-mediated differentiation

Photochemical activation of MH3-B1/rGel: a HER2-targeted treatment approach for ovarian cancer

SEL1L SNP rs12435998, a predictor of glioblastoma survival and response to radio-chemotherapy

Targeting the inhibitory receptor CTLA-4 on T cells increased abscopal effects in murine mesothelioma model

Induction of c-Cbl contributes to anti-cancer effects of HDAC inhibitor in lung cancer

Combining TGF-β1 knockdown and miR200c administration to optimize antitumor efficacy of B16F10/GPI-IL-21 vaccine

Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines

Biological and clinical effects of abiraterone on anti-resorptive and anabolic activity in bone microenvironment

Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB signaling

miRNA-target network reveals miR-124as a key miRNA contributing to clear cell renal cell carcinoma aggressive behaviour by targeting CAV1 and FLOT1

Tumor suppressive microRNA-137 negatively regulates Musashi-1 and colorectal cancer progression

5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair

Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer

Quercetin-induced apoptosis prevents EBV infection

MAP17 (PDZKIP1) as a novel prognostic biomarker for laryngeal cancer

A STAT3-NFkB/DDIT3/CEBPβ axis modulates ALDH1A3 expression in chemoresistant cell subpopulations

High USP22 expression indicates poor prognosis in hepatocellular carcinoma

Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner

Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells

FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC

Genomic analysis of xCT-mediated regulatory network: identification of novel targets against AIDS-associated lymphoma

JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells

A standardized autopsy procurement allows for the comprehensive study of DIPG biology

Metformin potentiates rapamycin and cisplatin in gastric cancer in mice

Differences in breast cancer characteristics and outcomes between Caucasian and Chinese women in the US

Molecular heterogeneity assessment by next-generation sequencing and response to gefitinib of EGFR mutant advanced lung adenocarcinoma

Dual targeting of HER1/EGFR and HER2 with cetuximab and trastuzumab in patients with metastatic pancreatic cancer after gemcitabine failure: results of the “THERAPY”phase 1-2 trial

Actionable mutations in plasma cell-free DNA in patients with advanced cancers referred for experimental targeted therapies

HOXB13 overexpression is an independent predictor of early PSA recurrence in prostate cancer treated by radical prostatectomy