Intracellular HMGB1: defender of client proteins and cell fate

Targeting Hsp90 in urothelial carcinoma

MicroRNAs in apoptosis, autophagy and necroptosis

The biology and treatment of oligometastatic cancer

Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors

Prognostic and predictive values of long non-coding RNA LINC00472 in breast cancer

Crosstalk between Desmoglein 2 and Patched 1 accelerates chemical-induced skin tumorigenesis

D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth

DACH1 is a novel predictive and prognostic biomarker in hepatocellular carcinoma as a negative regulator of Wnt/β-catenin signaling

RIPK3 expression in cervical cancer cells is required for PolyIC-induced necroptosis, IL-1α release, and efficient paracrine dendritic cell activation

Basal and therapy-driven hypoxia-inducible factor-1α confers resistance to endocrine therapy in estrogen receptor-positive breast cancer

Enhancement of tumor initiation and expression of KCNMA1, MORF4L2 and ASPM genes in the adenocarcinoma of lung xenograft after vorinostat treatment

A novel role for microRNA-129-5p in inhibiting ovarian cancer cell proliferation and survival via direct suppression of transcriptional co-activators YAP and TAZ

The stromal genome heterogeneity between breast and prostate tumors revealed by a comparative transcriptomic analysis

Paxillin promotes colorectal tumor invasion and poor patient outcomes via ERK-mediated stabilization of Bcl-2 protein by phosphorylation at Serine 87

Cleaved CD44 intracellular domain supports activation of stemness factors and promotes tumorigenesis of breast cancer

Identification of a novel synthetic lethality of combined inhibition of hedgehog and PI3K signaling in rhabdomyosarcoma

PLK1 is a critical determinant of tumor cell sensitivity to CPT11 and its inhibition enhances the drug antitumor efficacy in squamous cell carcinoma models sensitive and resistant to camptothecins

Biological rational for sequential targeting of Bruton tyrosine kinase and Bcl-2 to overcome CD40-induced ABT-199 resistance in mantle cell lymphoma

TRPM7 maintains progenitor-like features of neuroblastoma cells: implications for metastasis formation

Overexpression of Rad51C splice variants in colorectal tumors

Targeted therapy of glioblastoma stem-like cells and tumor non-stem cells using cetuximab-conjugated iron-oxide nanoparticles

Anterior gradient protein 2 expression in high grade head and neck squamous cell carcinoma correlated with cancer stem cell and epithelial mesenchymal transition

The attenuated hepatocellular carcinoma-specific Listeria vaccine Lmdd-MPFG prevents tumor occurrence through immune regulation of dendritic cells

Constitutive asymmetric dimerization drives oncogenic activation of epidermal growth factor receptor carboxyl-terminal deletion mutants

The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1

MicroRNA profiling identifies MiR-195 suppresses osteosarcoma cell metastasis by targeting CCND1

Dual effects of collagenase-3 on melanoma: metastasis promotion and disruption of vasculogenic mimicry

Macrophages promote benzopyrene-induced tumor transformation of human bronchial epithelial cells by activation of NF-κB and STAT3 signaling in a bionic airway chip culture and in animal models

MiR-203 downregulation is responsible for chemoresistance in human glioblastoma by promoting epithelial-mesenchymal transition via SNAI2

Knockdown of EphB1 receptor decreases medulloblastoma cell growth and migration and increases cellular radiosensitization

Split anergized Natural Killer cells halt inflammation by inducing stem cell differentiation, resistance to NK cell cytotoxicity and prevention of cytokine and chemokine secretion

Dual targeting of microtubule and topoisomerase II by α-carboline derivative YCH337 for tumor proliferation and growth inhibition

GSK3 is required for rapalogs to induce degradation of some oncogenic proteins and to suppress cancer cell growth

Novel harmine derivatives for tumor targeted therapy

Synergistic inhibition of autophagy and neddylation pathways as a novel therapeutic approach for targeting liver cancer

Cell type of origin as well as genetic alterations contribute to breast cancer phenotypes

WIP1 stimulates migration and invasion of salivary adenoid cystic carcinoma by inducing MMP-9 and VEGF-C

Antibody and lectin target podoplanin to inhibit oral squamous carcinoma cell migration and viability by distinct mechanisms

IL-32α suppresses colorectal cancer development via TNFR1-mediated death signaling

Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer

Inhibition of the HER2-YB1-AR axis with Lapatinib synergistically enhances Enzalutamide anti-tumor efficacy in castration resistant prostate cancer

The SOX17/miR-371-5p/SOX2 axis inhibits EMT, stem cell properties and metastasis in colorectal cancer

Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy

MicroRNA-155 expression is independently predictive of outcome in chordoma

By activating matrix metalloproteinase-7, shear stress promotes chondrosarcoma cell motility, invasion and lung colonization

The long non-coding RNA HNF1A-AS1 regulates proliferation and metastasis in lung adenocarcinoma

ANO1/TMEM16A interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer

FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia

Mer receptor tyrosine kinase is frequently overexpressed in human non-small cell lung cancer, confirming resistance to erlotinib

The cAMP responsive element binding protein 1 transactivates epithelial membrane protein 2, a potential tumor suppressor in the urinary bladder urothelial carcinoma

FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15

miR-340 suppresses glioblastoma multiforme

The mitochondrial carrier SLC25A10 regulates cancer cell growth

Cytoplasmic accumulation of NCoR in malignant melanoma: consequences of altered gene repression and prognostic significance

A pentacyclic triterpene natural product, ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis

Up-regulation of CD44 in the development of metastasis, recurrence and drug resistance of ovarian cancer

Co-inhibition of polo-like kinase 1 and Aurora kinases promotes mitotic catastrophe

A novel small-form NEDD4 regulates cell invasiveness and apoptosis to promote tumor metastasis

Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development

HPV16 E5 deregulates the autophagic process in human keratinocytes

Gut bacteria require neutrophils to promote mammary tumorigenesis

CIP4 promotes metastasis in triple-negative breast cancer and is associated with poor patient prognosis

Temporal regulation of HIF-1 and NF-κB in hypoxic hepatocarcinoma cells

PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis

Heterogeneous chromosome 12p deletion is an independent adverse prognostic factor and resistant to bortezomib-based therapy in multiple myeloma

MiR-195 suppresses non-small cell lung cancer by targeting CHEK1

miR-211 suppresses hepatocellular carcinoma by downregulating SATB2

Quantification of cellular viability by automated microscopy and flow cytometry

Lyn modulates Claudin-2 expression and is a therapeutic target for breast cancer liver metastasis

Translation initiation complex eIF4F is a therapeutic target for dual mTOR kinase inhibitors in non-Hodgkin lymphoma

TRAIL-R2 promotes skeletal metastasis in a breast cancer xenograft mouse model

Transcriptional co-activator TAZ sustains proliferation and tumorigenicity of neuroblastoma by targeting CTGF and PDGF-β

Podoplanin-expressing cancer-associated fibroblasts inhibit small cell lung cancer growth

Serum thioredoxin is a diagnostic marker for hepatocellular carcinoma

Polymorphism in one-carbon metabolism pathway affects survival of gastric cancer patients: Large and comprehensive study

Inactivation of bone morphogenetic protein 2 may predict clinical outcome and poor overall survival for renal cell carcinoma through epigenetic pathways

Elevated serum CA72-4 levels predict poor prognosis in pancreatic adenocarcinoma after intensity-modulated radiation therapy

Prognostic value of receptor conversion after neoadjuvant chemotherapy in breast cancer patients: a prospective observational study

Hypomethylation and up-regulation of PD-1 in T cells by azacytidine in MDS/AML patients: A rationale for combined targeting of PD-1 and DNA methylation

Head and neck cancer subtypes with biological and clinical relevance: Meta-analysis of gene-expression data