Unique molecular signatures as a hallmark of patients with metastatic breast cancer: Implications for current treatment paradigms

Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma

The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway

Alternative splicing of FBP-interacting repressor coordinates c-Myc, P27Kip1/cyclinE and Ku86/XRCC5 expression as a molecular sensor for bleomycin-induced DNA damage pathway

SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I

Bak and Mcl-1 are essential for Temozolomide induced cell death in human glioma

WT1 regulates angiogenesis in Ewing Sarcoma

Enrichment of circulating melanoma cells (CMCs) using negative selection from patients with metastatic melanoma.

YB-1 expression promotes epithelial-to-mesenchymal transition in prostate cancer that is inhibited by a small molecule fisetin

FAAH inhibition enhances anandamide mediated anti-tumorigenic effects in non-small cell lung cancer by downregulating the EGF/EGFR pathway

A DNA repair pathway score predicts survival in human multiple myeloma: the potential for therapeutic strategy

A high-content morphological screen identifies novel microRNAs that regulate neuroblastoma cell differentiation

miR-199a-3p displays tumor suppressor functions in papillary thyroid carcinoma

STAT3 down regulates LC3 to inhibit autophagy and pancreatic cancer cell growth

Hyperactivation of Akt/mTOR and deficiency in tuberin increased the oxidative DNA damage in kidney cancer patients with diabetes

ATRX mRNA expression combined with IDH1/2 mutational status and Ki-67 expression refines the molecular classification of astrocytic tumors: evidence from the whole transcriptome sequencing of 169 samples

IGF-1R, a target of let-7b, mediates crosstalk between IRS-2/Akt and MAPK pathways to promote proliferation of oral squamous cell carcinoma

Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth

Biomarkers of reactive resistance and early disease progression during chemotherapy plus bevacizumab treatment for colorectal carcinoma

HOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin-11 expression

YAP1 acts as oncogenic target of 11q22 amplification in multiple cancer subtypes.

Targeting the MUC1-C oncoprotein inhibits self-renewal capacity of breast cancer cells

Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma

Heat shock protein 27 regulates human prostate cancer cell motility and metastatic progression

Isorhapontigenin (ISO) inhibited cell transformation by inducing G0/G1 phase arrest via increasing MKP-1 mRNA stability

Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells

Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma

Hyperactivation of Alk induces neonatal lethality in knock-in Alk^F1178L mice

The anti-apoptotic form of tyrosine kinase Lyn that is generated by proteolysis is degraded by the N-end rule pathway

Oncogenic functions of IGF1R and INSR in prostate cancer include enhanced tumor growth, cell migration and angiogenesis

Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer

The characterization of a novel monoclonal antibody against CD93 unveils a new antiangiogenic target.

Direct endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice

Indoleamine 2,3-dioxygenase mediates immune-independent human tumor cell resistance to olaparib, gamma radiation, and cisplatin

microRNA-148a dysregulation discriminates poor prognosis of hepatocellular carcinoma in association with USP4 overexpression

Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells, and synergizes with irinotecan

RNA binding protein RBM14 promotes radio-resistance in glioblastoma by regulating DNA repair and cell differentiation

ROS-induced epithelial-mesenchymal transition in mammary epithelial cells is mediated by NF-κB-dependent activation of Snail

Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups

Strategy to enhance the therapeutic effect of doxorubicin in human hepatocellular carcinoma by selenocystine, a synergistic agent that regulates the ROS-mediated signaling