About The Cover
Structural modeling of celecoxib, DMC and other small molecule inhibitors binding to CDH11 and inhibiting the growth of MDA-MB-231 cells. Sd-133 binding capability to CDH11 was validated by SPR. Shown is a EC1 homodimer interface of CDH11 (PDB: 2A4C); one monomer is represented by the Van der Waals molecular surface (green) and the other by a ribbon. See Assefnia et al.
Table of Contents
Editorial
Invasive leader cells: metastatic oncotarget
| Invasive leader cells: metastatic oncotarget |
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https://doi.org/10.18632/oncotarget.1870 Kevin J. Cheung, and Andrew J. Ewald |
| 1390-1391 |
| PDF | How to cite |
Reviews
Molecular pathways and therapeutic targets in lung cancer
| Molecular pathways and therapeutic targets in lung cancer |
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https://doi.org/10.18632/oncotarget.1891 Emma Shtivelman, Thomas Hensing, George R. Simon, Phillip A. Dennis, Gregory A. Otterson, Raphael Bueno, and Ravi Salgia |
| 1392-1433 |
| Abstract | PDF | HTML | How to cite |
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Research Perspectives
The lncRNAs PCGEM1 and PRNCR1 are not implicated in castration resistant prostate cancer
| The lncRNAs PCGEM1 and PRNCR1 are not implicated in castration resistant prostate cancer |
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https://doi.org/10.18632/oncotarget.1846 John R. Prensner, Anirban Sahu, Matthew K. Iyer, Rohit Malik, Benjamin Chandler, Irfan A. Asangani, Anton Poliakov, Ismael A. Vergara, Mohammed Alshalalfa, Robert B. Jenkins, Elai Davicioni, Felix Y. Feng, and Arul M. Chinnaiyan |
| 1434-1438 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
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Research Papers
Capturing the biological impact of CDKN2A and MC1R genes as an early predisposing event in melanoma and non melanoma skin cancer.
| Capturing the biological impact of CDKN2A and MC1R genes as an early predisposing event in melanoma and non melanoma skin cancer. |
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https://doi.org/10.18632/oncotarget.1444 María José Escamez, Francisco Garcia-Garcia, Gemma Tell-Marti, Angels Fabra, Lucía Martínez-Santamaría, Celia Badenas, Paula Aguilera, Marta Pevida, Joaquín Dopazo, Marcela del Río, and Susana Puig |
| 1439-1451 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
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The genetic landscape of anaplastic astrocytoma
| The genetic landscape of anaplastic astrocytoma |
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https://doi.org/10.18632/oncotarget.1505 Patrick J. Killela, Christopher J. Pirozzi, Zachary J. Reitman, Sian Jones, B. Ahmed Rasheed, Eric Lipp, Henry Friedman, Allan H. Friedman, Yiping He, Roger E. McLendon, Darell D. Bigner, and Hai Yan |
| 1452-1457 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies.
| Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies. |
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https://doi.org/10.18632/oncotarget.1538 Shahin Assefnia, Sivanesan Dakshanamurthy, Jaime M. Guidry Auvil, Constanze Hampel, Panos Z. Anastasiadis, Bhaskar Kallakury, Aykut Uren, David W. Foley, Milton L. Brown, Lawrence Shapiro, Michael Brenner, David Haigh, and Stephen W. Byers |
| 1458-1474 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN
| Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN |
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https://doi.org/10.18632/oncotarget.1745 Tian-Huei Chu, Hoi-Hung Chan, Hsiao-Mei Kuo, Li-Fen Liu, Tsung-Hui Hu, Cheuk-Kwan Sun, Mei-Lang Kung, Shih-Wei Lin, E-Ming Wang, Yi-Ling Ma, Kwan-Hung Cheng, Kwok-Hung Lai, Zhi-Hong Wen, Ping-I Hsu, and Ming-Hong Tai |
| 1475-1490 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
C-kit induces epithelial–mesenchymal transition and contributes to salivary adenoid cystic cancer progression
| C-kit induces epithelial–mesenchymal transition and contributes to salivary adenoid cystic cancer progression |
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https://doi.org/10.18632/oncotarget.1606 Ya-ling Tang, Yun-long Fan, Jian Jiang, Kai-de Li, Min Zheng, Wei Chen, Xiang-rui Ma, Ning Geng, Qian-ming Chen, Yu Chen, and Xinhua Liang |
| 1491-1501 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity
| Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity |
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https://doi.org/10.18632/oncotarget.1609 Adrienne L. Watson, Bryant J. Keller, Kyle A. Williams, Namrata N. Damle, Samuel J. Finnerty, Leah K. Anderson, Andrew D. Greeley, Vincent W. Keng, Eric P. Rahrmann, Amanda L. Halfond, Natasha M. Powell, Margaret H. Collins, Tilat Rizvi, Christopher L. Moertel, Nancy Ratner, and David A. Largaespada |
| 1502-1514 |
| Abstract | PDF | HTML | How to cite |
Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas
| Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas |
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https://doi.org/10.18632/oncotarget.1765 Patrick J. Killela, Christopher J. Pirozzi, Patrick Healy, Zachary J. Reitman, Eric Lipp, Ahmed B. Rasheed, Rui Yang, Bill H. Diplas, Zhaohui Wang, Paula K. Greer, Huishan Zhu, Catherine Y. Wang, Austin B. Carpenter, Henry Friedman, Allan H. Friedman, Stephen T. Keir, Jie He, Yiping He, Roger E. McLendon, James E. Herndon II, Hai Yan, and Darell D. Bigner |
| 1515-1525 |
| Abstract | PDF | HTML | How to cite |
Atg7- and Keap1-dependent autophagy protects breast cancer cell lines against mitoquinone-induced oxidative stress
| Atg7- and Keap1-dependent autophagy protects breast cancer cell lines against mitoquinone-induced oxidative stress |
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https://doi.org/10.18632/oncotarget.1715 Yanira Gonzalez, Baikuntha Aryal, Leena Chehab, and V Ashutosh Rao |
| 1526-1537 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
The receptor for urokinase-plasminogen activator (uPAR) controls plasticity of cancer cell movement in mesenchymal and amoeboid migration style
| The receptor for urokinase-plasminogen activator (uPAR) controls plasticity of cancer cell movement in mesenchymal and amoeboid migration style |
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https://doi.org/10.18632/oncotarget.1754 Francesca Margheri, Cristina Luciani, Maria Letizia Taddei, Elisa Giannoni, Anna Laurenzana, Alessio Biagioni, Anastasia Chillà, Paola Chiarugi, Gabriella Fibbi, and Mario Del Rosso |
| 1538-1553 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
RhoGDI2 promotes epithelial-mesenchymal transition via induction of Snail in gastric cancer cells
| RhoGDI2 promotes epithelial-mesenchymal transition via induction of Snail in gastric cancer cells |
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https://doi.org/10.18632/oncotarget.1733 Hee Jun Cho, Sun-Mi Park, In-Kyu Kim, In-Koo Nam, Kyoung Eun Baek, Min-Ju Im, Jong-Min Yoo, Seung-Ho Park, Ki-Jun Ryu, Hyun-Tak Han, Hyo-Jin Kim, Soon-Chan Hong, Kwang Dong Kim, Yunbae Pak, Jae Won Kim, Chang Won Lee, and Jiyun Yoo |
| 1554-1564 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Thermoregulatory correlates of nausea in rats and musk shrews
| Thermoregulatory correlates of nausea in rats and musk shrews |
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https://doi.org/10.18632/oncotarget.1732 Sukonthar Ngampramuan, Matteo Cerri, Flavia Del Vecchio, Joshua J. Corrigan, Amornrat Kamphee, Alexander S. Dragic, John A. Rudd, Andrej Romanovsky, and Eugene Nalivaiko |
| 1565-1575 |
| Abstract | PDF | HTML | How to cite |
Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer
| Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer |
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https://doi.org/10.18632/oncotarget.1738 Saverio Candido, Roberta Maestro, Jerry Polesel, Alessia Catania, Francesca Maira, Santo S. Signorelli, James A. McCubrey, and Massimo Libra |
| 1576-1594 |
| Abstract | PDF | HTML | How to cite |
Prostate cancer-derived CCN3 induces M2 macrophage infiltration and contributes to angiogenesis in prostate cancer microenvironment
| Prostate cancer-derived CCN3 induces M2 macrophage infiltration and contributes to angiogenesis in prostate cancer microenvironment |
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https://doi.org/10.18632/oncotarget.1570 Po-Chun Chen, Hsu-Chen Cheng, John Wang, Shin-Wei Wang, Huai-Ching Tai, Chiao-Wen Lin, and Chih-Hsin Tang |
| 1595-1608 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
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TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities
| TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities |
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https://doi.org/10.18632/oncotarget.1707 Zenobia C. D'Costa, Catherine A. Higgins, Chee Wee Ong, Gareth Irwin, David Boyle, Darragh G. McArt, Karen McCloskey, Niamh E. Buckley, Nyree T. Crawford, Lalitha Thiagarajan, James T. Murray, Richard D. Kennedy, Karl A. Mulligan, Denis P. Harkin, David J.J. Waugh, Chris J. Scott, Manuel Salto-Tellez, Richard Williams, and Paul B. Mullan |
| 1609-1620 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication
| Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication |
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https://doi.org/10.18632/oncotarget.1764 Tobias Forster, Vanessa Rausch, Yiyao Zhang, Orkhan Isayev, Katharina Heilmann, Frank Schoensiegel, Li Liu, Michelle Nessling, Karsten Richter, Sabrina Labsch, Clifford C. Nwaeburu, Juergen Mattern, Jury Gladkich, Nathalia Giese, Jens Werner, Peter Schemmer, Wolfgang Gross, Martha M. Gebhard, Clarissa Gerhauser, Michael Schaefer, and Ingrid Herr |
| 1621-1634 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Diagnosis of bladder cancer and prediction of survival by urinary metabolomics
| Diagnosis of bladder cancer and prediction of survival by urinary metabolomics |
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https://doi.org/10.18632/oncotarget.1744 Xing Jin, Seok Joong Yun, Pildu Jeong, Isaac Yi Kim, Wun-Jae Kim, and Sunghyouk Park |
| 1635-1645 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy
| Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy |
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https://doi.org/10.18632/oncotarget.1802 Bo Cao, Yanfeng Qi, Guanyi Zhang, Duo Xu, Yang Zhan, Xavier Alvarez, Zhiyong Guo, Xueqi Fu, Stephen R. Plymate, Oliver Sartor, Haitao Zhang, and Yan Dong |
| 1646-1656 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
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Linking differential radiation responses to glioma heterogeneity
| Linking differential radiation responses to glioma heterogeneity |
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https://doi.org/10.18632/oncotarget.1823 Chao Ke, Katherine Tran, Yumay Chen, Anne T. Di Donato, Liping Yu, Yuanjie Hu, Mark E. Linskey, Ping H. Wang, Charles L. Limoli, and Yi-Hong Zhou |
| 1657-1665 |
| Abstract | PDF | HTML | How to cite |
The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling
| The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling |
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https://doi.org/10.18632/oncotarget.1850 Ricardo G. Correa, Maryla Krajewska, Carl F. Ware, Motti Gerlic, and John C. Reed |
| 1666-1682 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Strigolactone analogues induce apoptosis through activation of p38 and the stress response pathway in cancer cell lines and in conditionally reprogrammed primary prostate cancer cells.
| Strigolactone analogues induce apoptosis through activation of p38 and the stress response pathway in cancer cell lines and in conditionally reprogrammed primary prostate cancer cells. |
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https://doi.org/10.18632/oncotarget.1849 Claire B. Pollock, Sara McDonough, Victor S. Wang, Hyojung Lee, Lymor Ringer, Xin Li, Cristina Prandi, Richard J. Lee, Adam S. Feldman, Hinanit Koltai, Yoram Kapulnik, Olga C. Rodriguez, Richard Schlegel, Christopher Albanese, and Ronit I. Yarden |
| 1683-1698 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
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