About The Cover
The cover for the December issue of Oncotarget was taken from Mira et al. Entitled " Lovastatin regulates Tg-neu tumor vascular phenotype.", shown is FITC-lectin-perfused Vhcl-.
Table of Contents
Editorial Materials
MicroRNAs as regulators of tumor-associated stromal cells
| MicroRNAs as regulators of tumor-associated stromal cells |
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https://doi.org/10.18632/oncotarget.1625 Brian Ell, and Yibin Kang |
| 2166-2167 |
| PDF | How to cite |
MYC and MiR: vicious circle
| MYC and MiR: vicious circle |
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https://doi.org/10.18632/oncotarget.1602 Xiaohong Zhao, Xinwei Zhang, and Jianguo Tao |
| 2168-2169 |
| PDF | How to cite |
Wip1 and ATM in tumor evolution: role for BRCA1.
| Wip1 and ATM in tumor evolution: role for BRCA1. |
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https://doi.org/10.18632/oncotarget.1661 Doria Filipponi, and Dmitry V. Bulavin |
| 2170 |
| PDF | How to cite |
Reviews
Chemokines in tumor progression and metastasis
| Chemokines in tumor progression and metastasis |
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https://doi.org/10.18632/oncotarget.1426 Purvaba J. Sarvaiya, Donna Guo, Ilya V. Ulasov, Patrik Gabikian, and Maciej S. Lesniak |
| 2171-2185 |
| Abstract | PDF | HTML | How to cite |
Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms
| Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms |
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https://doi.org/10.18632/oncotarget.1497 Jahangir Abdi, Guoan Chen, and Hong Chang |
| 2186-2207 |
| Abstract | PDF | Erratum | HTML | How to cite |
Brief Reports
A loss-of-function mutation in PTCH1 suggests a role for autocrine hedgehog signaling in colorectal tumorigenesis
| A loss-of-function mutation in PTCH1 suggests a role for autocrine hedgehog signaling in colorectal tumorigenesis |
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https://doi.org/10.18632/oncotarget.1651 Jon H. Chung, and Fred Bunz |
| 2208-2211 |
| Abstract | PDF | HTML | How to cite |
Research Papers
Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype.
| Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype. |
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https://doi.org/10.18632/oncotarget.1143 Mickaël Ohanna, Yann Cheli, Caroline Bonet, Vanessa F Bonazzi, Marylin Allegra, Sandy Giuliano, Karine Bille, Philippe Bahadoran, Damien Giacchero, Jean Philippe Lacour, Glen M Boyle, Nicholas F Hayward, Corine Bertolotto, and Robert Ballotti |
| 2212-2224 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Combinatorial antitumor effect of HDACs and the PI3K-Akt-mTOR pathway inhibition in a Pten deficient model of prostate cancer
| Combinatorial antitumor effect of HDACs and the PI3K-Akt-mTOR pathway inhibition in a Pten deficient model of prostate cancer |
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https://doi.org/10.18632/oncotarget.1314 Leigh Ellis, ShengYu Ku, Swathi Ramakrishnan, Elena Lasorsa, Gizzou Azabdaftari, Alejandro Godoy, and Roberto Pili |
| 2225-2236 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
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Identification of anaplastic lymphoma kinase as a potential therapeutic target in Basal Cell Carcinoma
| Identification of anaplastic lymphoma kinase as a potential therapeutic target in Basal Cell Carcinoma |
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https://doi.org/10.18632/oncotarget.1357 Hanna Ning, Hiroshi Mitsui, Claire Q.F. Wang, Mayte Suárez-Fariñas, Juana Gonzalez, Kejal R. Shah, Jie Chen, Israel Coats, Diane Felsen, John A. Carucci, and James G. Krueger |
| 2237-2248 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Induction of apoptosis by directing oncogenic Bcr-Abl into the nucleus
| Induction of apoptosis by directing oncogenic Bcr-Abl into the nucleus |
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https://doi.org/10.18632/oncotarget.1339 Zheng-Lan Huang, Miao Gao, Qian-Yin Li, Kun Tao, Qing Xiao, Wei-Xi Cao, and Wen-Li Feng |
| 2249-2260 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Reduction of MLH1 and PMS2 confers temozolomide resistance and is associated with recurrence of glioblastoma
| Reduction of MLH1 and PMS2 confers temozolomide resistance and is associated with recurrence of glioblastoma |
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https://doi.org/10.18632/oncotarget.1302 Yoshinari Shinsato, Tatsuhiko Furukawa, Shunji Yunoue, Hajime Yonezawa, Kentarou Minami, Yukihiko Nishizawa, Ryuji Ikeda, Kohichi Kawahara, Masatatsu Yamamoto, Hirofumi Hirano, Hiroshi Tokimura, and Kazunori Arita |
| 2261-2270 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
A tumor-promoting mechanism mediated by retrotransposon-encoded reverse transcriptase is active in human transformed cell lines
| A tumor-promoting mechanism mediated by retrotransposon-encoded reverse transcriptase is active in human transformed cell lines |
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https://doi.org/10.18632/oncotarget.1403 Ilaria Sciamanna, Alberto Gualtieri, Cristina Cossetti, Emanuele Felice Osimo, Manuela Ferracin, Gianfranco Macchia, Eleonora Arico, Gianni Prosseda, Patrizia Vitullo, Tom Misteli, and Corrado Spadafora |
| 2271-2287 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
A lovastatin-elicited genetic program inhibits M2 macrophage polarization and enhances T cell infiltration into spontaneous mouse mammary tumors
| A lovastatin-elicited genetic program inhibits M2 macrophage polarization and enhances T cell infiltration into spontaneous mouse mammary tumors |
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https://doi.org/10.18632/oncotarget.1376 Emilia Mira, Lorena Carmona-Rodríguez, Manuel Tardáguila, Iñigo Azcoitia, Alicia González-Martín, Luis Almonacid, Josefina Casas, Gemma Fabriás, and Santos Mañes |
| 2288-2301 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Impaired angiogenesis and tumor development by inhibition of the mitotic kinesin Eg5
| Impaired angiogenesis and tumor development by inhibition of the mitotic kinesin Eg5 |
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https://doi.org/10.18632/oncotarget.1490 Prisca Exertier, Sophie Javerzat, Baigang Wang, Mélanie Franco, John M. Herbert, Natalia Platonova, Marie Winandy, Nadège Pujol, Olivier Nivelles, Sandra Ormenese, Virginie Godard, Jürgen Becker, Roy Bicknell, Raphael Pineau, Jörg Wilting, Andreas Bikfalvi, and Martin Hagedorn |
| 2302-2316 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
HOXA11 hypermethylation is associated with progression of non-small cell lung cancer
| HOXA11 hypermethylation is associated with progression of non-small cell lung cancer |
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https://doi.org/10.18632/oncotarget.1464 Jung-Ah Hwang, Bo Bin Lee, Yujin Kim, Seong-Eun Park, Kyun Heo, Seung-Hyun Hong, Young-Ho Kim, Joungho Han, Duk-Hwan Kim, Young Mog Shim, and Yeon-Su Lee |
| 2317-2325 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity
| Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity |
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https://doi.org/10.18632/oncotarget.1554 Ling Yu, Shiqing Liu, Chun Zhang, Bo Zhang, Bruno M. Simoes, Rachel Eyre, Yi Liang, Huichao Yan, Zheng Wu, Weichun Guo, and Robert B. Clarke |
| 2326-2338 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
SCFβ-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration
| SCFβ-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration |
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https://doi.org/10.18632/oncotarget.1446 Jiateng Zhong, Shavali Shaik, Lixin Wan, Adriana E. Tron, Zhiwei Wang, Liankun Sun, Hiroyuki Inuzuka, and Wenyi Wei |
| 2339-2353 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Inhibition of SIRT2 in merlin/NF2-mutant Schwann cells triggers necrosis
| Inhibition of SIRT2 in merlin/NF2-mutant Schwann cells triggers necrosis |
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https://doi.org/10.18632/oncotarget.1422 Alejandra M. Petrilli, Marga Bott, and Cristina Fernández-Valle |
| 2354-2365 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Ovarian cancer stem-like cells with induced translineage-differentiation capacity and are suppressed by alkaline phosphatase inhibitor
| Ovarian cancer stem-like cells with induced translineage-differentiation capacity and are suppressed by alkaline phosphatase inhibitor |
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https://doi.org/10.18632/oncotarget.1424 Kuei-Chun Liu, Yi-Te Yo, Rui-Lan Huang, Yu-Chi Wang, Yu-Ping Liao, Tien-Shuo Huang, Tai-Kuang Chao, Chi-Kang Lin, Shao-Ju Weng, Kuo-Hsing Ma, Cheng-Chang Chang, Mu-Hsien Yu, and Hung-Cheng Lai |
| 2366-2382 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-κB activity
| EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-κB activity |
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https://doi.org/10.18632/oncotarget.1434 Jung-Min Choi, Sushil Devkota, Young Hoon Sung, and Han-Woong Lee |
| 2383-2396 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
1 alpha, 25-dihydroxylvitamin D3 promotes Bacillus Calmette-Guérin immunotherapy of bladder cancer
| 1 alpha, 25-dihydroxylvitamin D3 promotes Bacillus Calmette-Guérin immunotherapy of bladder cancer |
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https://doi.org/10.18632/oncotarget.1494 Jong-Wei Hsu, Peng-Nien Yin, Ronald Wood, James Messing, Edward Messing, and Yi-Fen Lee |
| 2397-2406 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
In situ mutation detection and visualization of intratumor heterogeneity for cancer research and diagnostics
| In situ mutation detection and visualization of intratumor heterogeneity for cancer research and diagnostics |
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https://doi.org/10.18632/oncotarget.1527 Ida Grundberg, Sara Kiflemariam, Marco Mignardi, Juliana Imgenberg-Kreuz, Karolina Edlund, Patrick Micke, Magnus Sundström, Tobias Sjöblom, Johan Botling, and Mats Nilsson |
| 2407-2418 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer.
| Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer. |
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https://doi.org/10.18632/oncotarget.1572 Anastasia Wyce, Yan Degenhardt, Yuchen Bai, BaoChau Le, Susan Korenchuk, Ming-Chih Crouthamel, Charles McHugh, Robert Vessella, Caretha Creasy, Peter Tummino, and Olena Barbash |
| 2419-2429 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
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Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells
| Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells |
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https://doi.org/10.18632/oncotarget.1431 Kai Wu, Qingshan Chang, Yongju Lu, Ping Qiu, Bailing Chen, Chitra Thakur, Jiaying Sun, Lingzhi Li, Anjaneyulu Kowluru, and Fei Chen |
| 2430-2438 |
| Abstract | PDF | HTML | How to cite |
Evaluation of Zinc (II) chelators for inhibiting p53-mediated apoptosis
| Evaluation of Zinc (II) chelators for inhibiting p53-mediated apoptosis |
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https://doi.org/10.18632/oncotarget.1535 Akinori Morita, Shinya Ariyasu, Soichiro Ohya, Ippei Takahashi, Bing Wang, Kaoru Tanaka, Takatoshi Uchida, Haruna Okazaki, Kengo Hanaya, Atsushi Enomoto, Mitsuru Nenoi, Masahiko Ikekita, Shin Aoki, and Yoshio Hosoi |
| 2439-2450 |
| Abstract | PDF | HTML | How to cite |
Dietary protein restriction inhibits tumor growth in human xenograft models of prostate and breast cancer
| Dietary protein restriction inhibits tumor growth in human xenograft models of prostate and breast cancer |
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https://doi.org/10.18632/oncotarget.1586 Luigi Fontana, Remi M. Adelaiye, Antonella L. Rastelli, Kiersten Marie Miles, Eric Ciamporcero, Valter D. Longo, Holly Nguyen, Robert Vessella, and Roberto Pili |
| 2451-2461 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
High aldehyde dehydrogenase activity identifies cancer stem cells in human cervical cancer
| High aldehyde dehydrogenase activity identifies cancer stem cells in human cervical cancer |
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https://doi.org/10.18632/oncotarget.1578 Shuyan Liu, and Pengsheng Zheng |
| 2462-2475 |
| Abstract | PDF | HTML | How to cite |
FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7
| FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7 |
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https://doi.org/10.18632/oncotarget.1581 Zeran Wang, Yueyong Liu, Pengju Zhang, Weiguo Zhang, Weijing Wang, Kenneth Curr, Guangwei Wei, and Jian-Hua Mao |
| 2476-2486 |
| Abstract | PDF | HTML | How to cite |
Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects
| Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects |
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https://doi.org/10.18632/oncotarget.1604 Jason U. Tilan, Congyi Lu, Susana Galli, Ewa Izycka-Swieszewska, Joshua P. Earnest, Asim Shabbir, Lindsay M. Everhart, Shuo Wang, Samantha Martin, Meredith Horton, Akanksha Mahajan, David Christian, Alison O'Neill, Hongkun Wang, Tingting Zhuang, Magdalena Czarnecka, Michael D. Johnson, Jeffrey A. Toretsky, and Joanna B. Kitlinska |
| 2487-2501 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth
| Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth |
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https://doi.org/10.18632/oncotarget.1540 Jinyun Chen, Franklin Chung, Guizhi Yang, Minying Pu, Hui Gao, Wei Jiang, Hong Yin, Vladimir Capka, Shailaja Kasibhatla, Bryan Laffitte, Savina Jaeger, Raymond Pagliarini, Yaoyu Chen, and Wenlai Zhou |
| 2502-2511 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Loss of E-cadherin activates EGFR-MEK/ERK signaling, which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer
| Loss of E-cadherin activates EGFR-MEK/ERK signaling, which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer |
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https://doi.org/10.18632/oncotarget.1463 Gab-Yong Bae, So-Jung Choi, Ji-Seon Lee, Jisuk Jo, Jinseon Lee, Jhingook Kim, and Hyuk-Jin Cha |
| 2512-2522 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Extracellular p53 fragment re-enters K-Ras mutated cells through the caveolin-1 dependent early endosomal system
| Extracellular p53 fragment re-enters K-Ras mutated cells through the caveolin-1 dependent early endosomal system |
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https://doi.org/10.18632/oncotarget.1550 Sun-Hye Lee, Tae-Gyun Woo, Su-Jin Lee, Nam-Chul Ha, and Bum-Joon Park |
| 2523-2531 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer
| The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer |
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https://doi.org/10.18632/oncotarget.1503 Zhongwu li, Yanling Wang, Jing Qiu, Qiang Li, Chunping Yuan, Wei Zhang, Dongmiao Wang, Jinhai Ye, Hongbin Jiang, Jianrong Yang, and Jie Cheng |
| 2532-2549 |
| Abstract | PDF | HTML | How to cite |
Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming
| Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming |
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https://doi.org/10.18632/oncotarget.1508 Veronica Martinez-Marignac, Nader Toban, Miguel Bazile, and Raquel Aloyz |
| 2550-2566 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Research Perspectives
Endothelial hypoxic metabolism in carcinogenesis and dissemination : HIF-A isoforms are a NO metastatic phenomenon
| Endothelial hypoxic metabolism in carcinogenesis and dissemination : HIF-A isoforms are a NO metastatic phenomenon |
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https://doi.org/10.18632/oncotarget.1461 Cristina Branco-Price, Colin E. Evans, and Randall S. Johnson |
| 2567-2576 |
| Abstract | PDF | HTML | How to cite |
Anti-oxidative stress response genes: bioinformatic analysis of their expression and relevance in multiple cancers
| Anti-oxidative stress response genes: bioinformatic analysis of their expression and relevance in multiple cancers |
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https://doi.org/10.18632/oncotarget.1658 Barak Rotblat, Thomas G. P. Grunewald, Gabriel Leprivier, Gerry Melino, and Richard A. Knight |
| 2577-2590 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
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