- Editorial Comments
- Reviews
- Special Feature: Editorial
- Brief Reports
- Research Papers
- Research Perspectives
About The Cover
Geminin localization in HME cells. Geminin localization in HME cells. Shown is the localization of geminin (green) and γ-tubulin (red) during in cytokinesis. See Blanchard et al.
Table of Contents
Editorial Comments
Galectin-1 as an oncotarget in gliomas and melanomas
| Galectin-1 as an oncotarget in gliomas and melanomas |
|
https://doi.org/10.18632/oncotarget.408 Florence Lefranc, Véronique Mathieu, and Robert Kiss |
| 892-893 |
| PDF | HTML | How to cite |
Resistance to EGFR inhibitors: Molecular determinants and the enigma of head and neck cancer
| Resistance to EGFR inhibitors: Molecular determinants and the enigma of head and neck cancer |
|
https://doi.org/10.18632/oncotarget.407 Luc G.T. Morris, and Timothy A. Chan |
| 894-895 |
| PDF | HTML | How to cite |
Reviews
Metformin: Multi-faceted protection against cancer
| Metformin: Multi-faceted protection against cancer |
|
https://doi.org/10.18632/oncotarget.387 Sonia Del Barco, Alejandro Vazquez-Martin, Sílvia Cufí, Cristina Oliveras-Ferraros, Joaquim Bosch-Barrera, Jorge Joven, Begoña Martin-Castillo, and Javier A Menendez |
| 896-917 |
| Abstract | PDF | HTML | How to cite |
AHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disorders
| AHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disorders |
|
https://doi.org/10.18632/oncotarget.405 Sharmin Esmailzadeh, and Xiaoyan Jiang |
| 918-934 |
| Abstract | PDF | HTML | How to cite |
Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target
| Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target |
|
https://doi.org/10.18632/oncotarget.416 Mourad Sanhaji, Claire T Friel, Linda Wordeman, Frank Louwen, and Juping Yuan |
| 935-947 |
| Abstract | PDF | HTML | How to cite |
Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor
| Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor |
|
https://doi.org/10.18632/oncotarget.389 Esha Madan, Rajan Gogna, Madan Bhatt, Uttam Pati, Periannan Kuppusamy, and Abbas Ali Mahdi |
| 948-957 |
| Abstract | PDF | HTML | How to cite |
Special Feature: Editorial
Mechanism of Activation of AMPK and Upregulation of OGG1 by Rapamycin in Cancer Cells
| Mechanism of Activation of AMPK and Upregulation of OGG1 by Rapamycin in Cancer Cells |
|
https://doi.org/10.18632/oncotarget.381 Samy L. Habib |
| 958-959 |
| Abstract | PDF | HTML | How to cite |
Brief Reports
Pilot study of a pediatric metronomic 4-drug regimen
| Pilot study of a pediatric metronomic 4-drug regimen |
|
https://doi.org/10.18632/oncotarget.358 Nicolas André, Sylvie Abed, Daniel Orbach, Corinne Armari Alla, Laetitia Padovani, Eddy Pasquier, Jean Claude Gentet, and Arnauld Verschuur |
| 960-965 |
| Abstract | PDF | HTML | How to cite |
MED12 exon 2 mutations are common in uterine leiomyomas from South African patients
| MED12 exon 2 mutations are common in uterine leiomyomas from South African patients |
|
https://doi.org/10.18632/oncotarget.370 Netta Mäkinen, Hanna-Riikka Heinonen, Shane Moore, Ian Tomlinson, Zephne van der Spuy, and Lauri Aaltonen |
| 966-969 |
| Abstract | PDF | HTML | How to cite |
CRIP1 expression is correlated with a favorable outcome and less metastases in osteosarcoma patients
| CRIP1 expression is correlated with a favorable outcome and less metastases in osteosarcoma patients |
|
https://doi.org/10.18632/oncotarget.398 Daniel Baumhoer, Mareike Elsner, Jan Smida, Stephanie Zillmer, Sandra Rauser, Cédrik Schoene, Benjamin Balluff, Stefan Bielack, Gernot Jundt, Axel Walch, and Michaela Nathrath |
| 970-975 |
| Abstract | PDF | HTML | How to cite |
Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas.
| Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas. |
|
https://doi.org/10.18632/oncotarget.410 Sandra Cantilena, Fabio Pastorino, Olesya Chayka, Annalisa Pezzolo, Vito Pistoia, Mirco Ponzoni, and Arturo Sala |
| 976-983 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Research Papers
PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation
| PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation |
|
https://doi.org/10.18632/oncotarget.362 Dannis Gilbert Van Vuurden, Esther Hulleman, Olga L.M. Meijer, Laurine E. Wedekind, Marcel Kool, Hendrik Witt, W. Peter Vandertop, Thomas Würdinger, David P. Noske, Gertjan J.L. Kaspers, and Jacqueline Cloos |
| 984-996 |
| Abstract | PDF | HTML | How to cite |
Antitumoral activity of allosteric inhibitors of Protein kinase CK2
| Antitumoral activity of allosteric inhibitors of Protein kinase CK2 |
|
https://doi.org/10.18632/oncotarget.361 Virginie Moucadel, Renaud Prudent, Céline F. Sautel, Florence Teillet, Caroline Barette, Laurence Lafanechere, Veronique Receveur-Brechot, and Claude Cochet |
| 997-1010 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Geminin overexpression induces mammary tumors via suppressing cytokinesis.
| Geminin overexpression induces mammary tumors via suppressing cytokinesis. |
|
https://doi.org/10.18632/oncotarget.363 Zannel Blanchard, Rohit Malik, Nicole Mullins, Christine Maric, Hugh Luk, David Horio, Brenda Hernandez, Jeffrey Killeen, and Wael M. ElShamy |
| 1011-1027 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Cord blood stem cells revert glioma stem cell EMT by down regulating transcriptional activation of Sox2 and Twist1
| Cord blood stem cells revert glioma stem cell EMT by down regulating transcriptional activation of Sox2 and Twist1 |
|
https://doi.org/10.18632/oncotarget.367 Kiran Kumar Velpula, Venkata Ramesh Dasari, Andrew J. Tsung, Dzung H. Dinh, and Jasti S. Rao |
| 1028-1042 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Putting the brakes on mammary tumorigenesis: Loss of STAT1 predisposes to intraepithelial neoplasias
| Putting the brakes on mammary tumorigenesis: Loss of STAT1 predisposes to intraepithelial neoplasias |
|
https://doi.org/10.18632/oncotarget.371 Christine Schneckenleithner, Zsuzsanna Bago-Horvath, Helmuth Dolznig, Nina Neugebauer, Karoline Kollmann, Thomas Kolbe, Thomas Decker, Dontscho Kerjaschki, Kay-Uwe Wagner, Mathias Müller, Dagmar Stoiber, and Veronika Sexl |
| 1043-1054 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
A Novel Dual Signaling Axis for NSP 5a3a induced apoptosis in Head and Neck Carcinoma
| A Novel Dual Signaling Axis for NSP 5a3a induced apoptosis in Head and Neck Carcinoma |
|
https://doi.org/10.18632/oncotarget.306 Luca D'Agostino, and Antonio Giordano |
| 1055-1074 |
| Abstract | PDF | HTML | How to cite |
Annexin A2 is a novel Cellular Redox Regulatory Protein involved in Tumorigenesis
| Annexin A2 is a novel Cellular Redox Regulatory Protein involved in Tumorigenesis |
|
https://doi.org/10.18632/oncotarget.375 Patricia Alexandra Madureira, Richard Hill, Victoria Ann Miller, Carman Giacomantonio, Patrick WK Lee, and David Morton Waisman |
| 1075-1093 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death
| DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death |
|
https://doi.org/10.18632/oncotarget.378 Richard Hill, Patricia A. Madureira, David M. Waisman, and Patrick W.K. Lee |
| 1094-1108 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors
| Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors |
|
https://doi.org/10.18632/oncotarget.380 Valeria G. Antico Arciuch, Marika A. Russo, Mariavittoria Dima, Kristy S. Kang, Florence Dasrath, Xiao-Hui Liao, Samuel Refetoff, Cristina Montagna, and Antonio Di Cristofano |
| 1109-1126 |
| Abstract | PDF | HTML | How to cite |
Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height
| Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height |
|
https://doi.org/10.18632/oncotarget.385 Katrina Tatton-Brown, Sandra Hanks, Elise Ruark, Anna Zachariou, Silvana Del Vecchio Duarte, Emma Ramsay, Katie Snape, Anne Murray, Elizabeth R. Perdeaux, Sheila Seal, Chey Loveday, Siddharth Banka, Carol Clericuzio, Frances Flinter, Alex Magee, Vivienne McConnell, Michael Patton, Wolfgang Raith, Julia Rankin, Miranda Splitt, Volker Strenger, Clare Taylor, Patricia Wheeler, I. Karen Temple, Trevor Cole, Jenny Douglas, and Nazneen Rahman |
| 1127-1133 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells
| PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells |
|
https://doi.org/10.18632/oncotarget.386 Allan Siu, Carl Virtanen, and Jan Jongstra |
| 1134-1144 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
|
TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death
| TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death |
|
https://doi.org/10.18632/oncotarget.391 Naveen Muppani, Ulrika Nyman, and Bertrand Joseph |
| 1145-1154 |
| Abstract | PDF | HTML | How to cite |
Phosphatase inhibitor, sodium stibogluconate, in combination with interferon (IFN) alpha 2b: phase I trials to identify pharmacodynamic and clinical effects
| Phosphatase inhibitor, sodium stibogluconate, in combination with interferon (IFN) alpha 2b: phase I trials to identify pharmacodynamic and clinical effects |
|
https://doi.org/10.18632/oncotarget.563 Taolin Yi, Paul Elson, Masato Mitsuhashi, Barbara Jacobs, Emese Hollovary, G. Thomas Budd, Timothy Spiro, Pierre Triozzi, and Ernest Borden |
| 1155-1164 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Overexpression of TWIST2 correlates with poor prognosis in Head and Neck Squamous Cell Carcinomas
| Overexpression of TWIST2 correlates with poor prognosis in Head and Neck Squamous Cell Carcinomas |
|
https://doi.org/10.18632/oncotarget.390 Daniela Gasparotto, Jerry Polesel, Alessandra Marzotto, Roberta Colladel, Sara Piccinin, Piergiorgio Modena, Alessandra Grizzo, Sandro Sulfaro, Diego Serraino, Luigi Barzan, Claudio Doglioni, and Roberta Maestro |
| 1165-1175 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins
| Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins |
|
https://doi.org/10.18632/oncotarget.397 Paula Vainio, Laura Lehtinen, Tuomas Mirtti, Mika Hilvo, Tuulikki Seppänen-Laakso, Johannes Virtanen, Anna Sankila, Stig Nordling, Johan Lundin, Antti Rannikko, Matej Orešič, Olli Kallioniemi, and Kristiina Iljin |
| 1176-1190 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
|
Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation
| Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation |
|
https://doi.org/10.18632/oncotarget.395 Michal Sheffer, Amos J. Simon, Jasmine Jacob-Hirsch, Gideon Rechavi, Eytan Domany, David Givol, and Gabriella D'Orazi |
| 1191-1202 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome
| Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome |
|
https://doi.org/10.18632/oncotarget.382 Paul M. Neilsen, Jacqueline E. Noll, Rachel J. Suetani, Renee B Schulz, Fares Al-Ejeh, Andreas Evdokiou, David P. Lane, and David F. Callen |
| 1203-1217 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
The suppression of FOXM1 and its targets in breast cancer xenograft tumors by siRNA
| The suppression of FOXM1 and its targets in breast cancer xenograft tumors by siRNA |
|
https://doi.org/10.18632/oncotarget.359 Ming Wang, and Andrei L. Gartel |
| 1218-1226 |
| Abstract | PDF | HTML | How to cite |
Characterization of the Human Folate Receptor Alpha Via Novel Antibody-Based Probes
| Characterization of the Human Folate Receptor Alpha Via Novel Antibody-Based Probes |
|
https://doi.org/10.18632/oncotarget.412 Daniel J. O’Shannessy, Elizabeth B. Somers, Earl Albone, Xin Cheng, Young Chul Park, Brian E. Tomkowicz, Yoshitomo Hamuro, Thomas O. Kohl, Tracy M. Forsyth, Robert Smale, Yao-Shi Fu, and Nicholas C. Nicolaides |
| 1227-1243 |
| Abstract | PDF | HTML | How to cite |
A Modular Strategy to Prepare Multivalent Inhibitors of Prostate-Specific Membrane Antigen (PSMA)
| A Modular Strategy to Prepare Multivalent Inhibitors of Prostate-Specific Membrane Antigen (PSMA) |
|
https://doi.org/10.18632/oncotarget.415 Sangeeta Ray Banerjee, Mrudula Pullambhatla, Hassan Shallal, Ala Lisok, Ronnie C. Mease, and Martin G. Pomper |
| 1244-1253 |
| Abstract | PDF | HTML | How to cite |
Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1)
| Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1) |
|
https://doi.org/10.18632/oncotarget.406 Nancy Liu-Sullivan, Jianping Zhang, Amy Bakleh, John Marchica, Jinyu Li, Despina Siolas, Sylvie Laquerre, Yan Y. Degenhardt, Richard Wooster, Kenneth Chang, Gregory J. Hannon, and Scott Powers |
| 1254-1264 |
| Abstract | PDF | HTML | How to cite |
Identification of a chrXq27.3 microRNA cluster associated with early relapse in advanced stage ovarian cancer patients
| Identification of a chrXq27.3 microRNA cluster associated with early relapse in advanced stage ovarian cancer patients |
|
https://doi.org/10.18632/oncotarget.401 Marina Bagnoli, Loris De Cecco, Anna Granata, Roberta Nicoletti, Edoardo Marchesi, Paola Alberti, Barbara Valeri, Massimo Libra, Mattia Barbareschi, Francesco Raspagliesi, Delia Mezzanzanica, and Silvana Canevari |
| 1265-1278 |
| Abstract | PDF | Addendum | HTML | Supplementary Information | How to cite |
Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1
| Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1 |
|
https://doi.org/10.18632/oncotarget.411 Yan Hu, Mary L. Spengler, Karen K. Kuropatwinski, Maria Comas, Marilyn Jackson, Mikhail V. Chernov, Anatoly S. Gleiberman, Natalia Fedtsova, Youcef M. Rustum, Andrei V. Gudkov, and Marina Antoch |
| 1279-1290 |
| Abstract | PDF | HTML | Supplementary Information | How to cite |
Epigenetic regulation of Delta-Like1 controls Notch1 activation in gastric cancer
| Epigenetic regulation of Delta-Like1 controls Notch1 activation in gastric cancer |
|
https://doi.org/10.18632/oncotarget.414 Giulia Piazzi, Lucia Fini, Michael Selgrad, Melissa Garcia, Yahya Daoud, Thomas Wex, Peter Malfertheiner, Antonio Gasbarrini, Marco Romano, Richard L. Meyer, Robert M Genta, James G. Fox, C. Richard Boland, Franco Bazzoli, and Luigi Ricciardiello |
| 1291-1301 |
| Abstract | PDF | HTML | How to cite |
Research Perspectives
Targeting Autophagy Addiction in Cancer
| Targeting Autophagy Addiction in Cancer |
|
https://doi.org/10.18632/oncotarget.384 Joseph D. Mancias, and Alec C. Kimmelman |
| 1302-1306 |
| Abstract | PDF | HTML | How to cite |
Finding cancer’s weakest link
| Finding cancer’s weakest link |
|
https://doi.org/10.18632/oncotarget.396 Nicole Michel Sodir, and Gerard I. Evan |
| 1307-1313 |
| Abstract | PDF | HTML | How to cite |
Will PI3K pathway inhibitors be effective as single agents in patients with cancer?
| Will PI3K pathway inhibitors be effective as single agents in patients with cancer? |
|
https://doi.org/10.18632/oncotarget.409 Joan T. Garrett, Anindita Chakrabarty, and Carlos L. Arteaga |
| 1314-1321 |
| Abstract | PDF | HTML | How to cite |
AMPK in BCR-ABL expressing leukemias. Regulatory effects and therapeutic implications.
| AMPK in BCR-ABL expressing leukemias. Regulatory effects and therapeutic implications. |
|
https://doi.org/10.18632/oncotarget.413 Leonidas Platanias, and Eliza Vakana |
| 1322-1328 |
| Abstract | PDF | HTML | How to cite |
Is human cytomegalovirus a target in cancer therapy?
| Is human cytomegalovirus a target in cancer therapy? |
|
https://doi.org/10.18632/oncotarget.383 John Inge Johnsen, Ninib Baryawno, and Cecilia Söderberg-Nauclér |
| 1329-1338 |
| Abstract | PDF | HTML | How to cite |
T cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancer
| T cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancer |
|
https://doi.org/10.18632/oncotarget.403 Abira Sarkar, Moses K. Donkor, and Ming O. Li |
| 1339-1351 |
| Abstract | PDF | HTML | How to cite |
NCI’s provocative questions on cancer: some answers to ignite discussion
| NCI’s provocative questions on cancer: some answers to ignite discussion |
|
https://doi.org/10.18632/oncotarget.432 Mikhail V. Blagosklonny |
| 1352-1367 |
| Abstract | PDF | HTML | How to cite |
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