Oncotarget

Volume 16 (2025)

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Table of Contents

Research Papers

Anti-correlation of KLRG1 and PD-1 expression in human tumor CD8 T cells

Anti-correlation of KLRG1 and PD-1 expression in human tumor CD8 T cells

https://doi.org/10.18632/oncotarget.28679

Steven A. Greenberg
1-8
Abstract  |  PDF  |  Full Text  |  How to cite  |  Press Release

Retraction

Retraction: Overexpression of lncRNA ANRIL up-regulates VEGF expression and promotes angiogenesis of diabetes mellitus combined with cerebral infarction by activating NF-κB signaling pathway in a rat model

Retraction: Overexpression of lncRNA ANRIL up-regulates VEGF expression and promotes angiogenesis of diabetes mellitus combined with cerebral infarction by activating NF-κB signaling pathway in a rat model

https://doi.org/10.18632/oncotarget.28572

Bo Zhang, Dan Wang, Tie-Feng Ji, Lei Shi,  and Jin-Lu Yu
9-9
Retraction  |  PDF  |  How to cite

Retraction

Retraction: Transient activation of the PI3K/Akt pathway promotes Newcastle disease virus replication and enhances anti-apoptotic signaling responses

Retraction: Transient activation of the PI3K/Akt pathway promotes Newcastle disease virus replication and enhances anti-apoptotic signaling responses

https://doi.org/10.18632/oncotarget.28683

Yinfeng Kang, Runyu Yuan, Xiaqiong Zhao, Bin Xiang, Shimin Gao, Pei Gao, Xu Dai, Minsha Feng, Yanling Li, Peng Xie, Yulian Li, Xiaoyi Gao,  and Tao Ren
10-10
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Reviews

Evolving concepts in HER2-low breast cancer: Genomic insights, definitions, and treatment paradigms

Evolving concepts in HER2-low breast cancer: Genomic insights, definitions, and treatment paradigms

https://doi.org/10.18632/oncotarget.28680

Whitney L. Hensing, Emily L. Podany, James J. Sears, Shaili Tapiavala,  and Andrew A. Davis
11-27
Abstract  |  PDF  |  Full Text  |  How to cite  |  Press Release

Retraction

Retraction: Lithium chloride inhibits titanium particle-induced osteoclastogenesis by inhibiting the NF-κB pathway

Retraction: Lithium chloride inhibits titanium particle-induced osteoclastogenesis by inhibiting the NF-κB pathway

https://doi.org/10.18632/oncotarget.28684

Xuanyang Hu, Zhirong Wang, Jiawei Shi, Xiaobin Guo, Liangliang Wang, Zichuan Ping, Yunxia Tao, Huilin Yang, Jun Zhou, Yaozeng Xu,  and Dechun Geng
28-28
Retraction  |  PDF  |  How to cite

Research Papers

Assessment of cfDNA release dynamics during colorectal cancer surgery

Assessment of cfDNA release dynamics during colorectal cancer surgery

https://doi.org/10.18632/oncotarget.28681

Mailson Alves Lopes, Maria Elvira Ribeiro Cordeiro, Flávio de Alencar Teles Barreto, Lara de Souza Moreno, André Araújo de Medeiros Silva, Mariana Braccialli de Loyola, Mayra Veloso Ayrimoraes Soares, Joao Batista de Sousa,  and Fabio Pittella-Silva
29-38
Abstract  |  PDF  |  Full Text  |  How to cite  |  Press Release

Case Reports

Acquired RUFY1-RET rearrangement as a mechanism of resistance to lorlatinib in a patient with CD74-ROS1 rearranged non-small cell lung cancer: A case report

Acquired RUFY1-RET rearrangement as a mechanism of resistance to lorlatinib in a patient with CD74-ROS1 rearranged non-small cell lung cancer: A case report

https://doi.org/10.18632/oncotarget.28682

Jenny L. Wu,  and Wade T. Iams
39-42
Abstract  |  PDF  |  Full Text  |  How to cite  |  Press Release

Retraction

Retraction: MicroRNA-145 down-regulates mucin 5AC to alleviate airway remodeling and targets EGFR to inhibit cytokine expression

Retraction: MicroRNA-145 down-regulates mucin 5AC to alleviate airway remodeling and targets EGFR to inhibit cytokine expression

https://doi.org/10.18632/oncotarget.28689

Zhe Cheng, Ling-Ling Dai, Xi Wang, Liu-Qun Jia, Xiao-Gang Jing, Peng-Fei Li, Meng Liu, Huan Wang,  and Lin An
43-43
Retraction  |  PDF  |  How to cite

Case Reports

A case report of donor cell–derived hematologic neoplasms 9 years after allogeneic hematopoietic cell transplantation

A case report of donor cell–derived hematologic neoplasms 9 years after allogeneic hematopoietic cell transplantation

https://doi.org/10.18632/oncotarget.28686

Aleksandra Mroczkowska-Bękarciak,  and Tomasz Wróbel
44-50
Abstract  |  PDF  |  Full Text  |  How to cite  |  Press Release

Reviews

SETDB1 amplification in osteosarcomas: Insights from its role in healthy tissues and other cancer types

SETDB1 amplification in osteosarcomas: Insights from its role in healthy tissues and other cancer types

https://doi.org/10.18632/oncotarget.28688

Elodie Verdier, Nathalie Gaspar, Maria Eugenia Marques Da Costa,  and Antonin Marchais
51-62
Abstract  |  PDF  |  Full Text  |  How to cite  |  Press Release

Corrections

Correction: Catalytic inhibitors of DNA topoisomerase II suppress the androgen receptor signaling and prostate cancer progression

Correction: Catalytic inhibitors of DNA topoisomerase II suppress the androgen receptor signaling and prostate cancer progression

https://doi.org/10.18632/oncotarget.28692

Haolong Li, Ning Xie, Martin E. Gleave,  and Xuesen Dong
63-64
Correction  |  PDF  |  How to cite

Corrections

Correction: Downregulation of c-SRC kinase CSK promotes castration resistant prostate cancer and pinpoints a novel disease subclass

Correction: Downregulation of c-SRC kinase CSK promotes castration resistant prostate cancer and pinpoints a novel disease subclass

https://doi.org/10.18632/oncotarget.28693

Chih-Cheng Yang, Ladan Fazli, Salvatore Loguercio, Irina Zharkikh, Pedro Aza-Blanc, Martin E. Gleave,  and Dieter A. Wolf
65-66
Correction  |  PDF  |  How to cite

Research Papers

Could Panitumumab with very low dose Capecitabine be an option as a maintenance regimen

Could Panitumumab with very low dose Capecitabine be an option as a maintenance regimen

https://doi.org/10.18632/oncotarget.28687

Doaa A. Gamal, Aiat Morsy,  and Mervat Omar
67-78
Abstract  |  PDF  |  Full Text  |  How to cite  |  Press Release

Research Papers

Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells

Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells

https://doi.org/10.18632/oncotarget.28690

Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz,  and Fred Bunz
79-100
Abstract  |  PDF  |  Full Text  |  How to cite  |  Press Release

Retraction

Retraction: Methylation-mediated repression of microRNA-129-2 suppresses cell aggressiveness by inhibiting high mobility group box 1 in human hepatocellular carcinoma

Retraction: Methylation-mediated repression of microRNA-129-2 suppresses cell aggressiveness by inhibiting high mobility group box 1 in human hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.28694

Zhikui Liu, Changwei Dou, Bowen Yao, Meng Xu, Linglong Ding, Yufeng Wang, Yuli Jia, Qing Li, Hongyong Zhang, Kangsheng Tu, Tao Song,  and Qingguang Liu
101-101
Retraction  |  PDF  |  How to cite

Retraction

Retraction: Ftx non coding RNA-derived miR-545 promotes cell proliferation by targeting RIG-I in hepatocellular carcinoma

Retraction: Ftx non coding RNA-derived miR-545 promotes cell proliferation by targeting RIG-I in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.28695

Zhikui Liu, Changwei Dou, Bowen Yao, Meng Xu, Linglong Ding, Yufeng Wang, Yuli Jia, Qing Li, Hongyong Zhang, Kangsheng Tu, Tao Song,  and Qingguang Liu
102-102
Retraction  |  PDF  |  How to cite

Research Papers

Leukopenia, weight loss and oral mucositis induced by 5-Fluorouracil in hamsters’ model: A regenerative approach using electrospun poly(Lactic-co-Glycolic Acid) membrane

Leukopenia, weight loss and oral mucositis induced by 5-Fluorouracil in hamsters’ model: A regenerative approach using electrospun poly(Lactic-co-Glycolic Acid) membrane

https://doi.org/10.18632/oncotarget.28685

Ana Chor, Hélio dos Santos Dutra, Marcos Lopes Dias, Raquel Pires Gonçalves, Alexandre Malta Rossi, Christina Maeda Takiya,  and Marcos Farina
103-117
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite  |  Press Release

Research Papers

Effect of TIMPs and their minimally engineered variants in blocking invasion and migration of brain cancer cells

Effect of TIMPs and their minimally engineered variants in blocking invasion and migration of brain cancer cells

https://doi.org/10.18632/oncotarget.28691

Elham Taheri,  and Maryam Raeeszadeh-Sarmazdeh
118-130
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite  |  Press Release

Retraction

Retraction: FKBP14 overexpression contributes to osteosarcoma carcinogenesis and indicates poor survival outcome

Retraction: FKBP14 overexpression contributes to osteosarcoma carcinogenesis and indicates poor survival outcome

https://doi.org/10.18632/oncotarget.28697

Zhongming Huang, Junhua Li, Shaohua Du, Yanghua Tang, Ligang Huang, Luwei Xiao,  and Peijian Tong
131-131
Retraction  |  PDF  |  How to cite

Addendum

Addendum: Assessment of cholecystokinin 2 receptor (CCK2R) in neoplastic tissue

Addendum: Assessment of cholecystokinin 2 receptor (CCK2R) in neoplastic tissue

https://doi.org/10.18632/oncotarget.28699

Jyoti Roy, Karson S. Putt, Domenico Coppola, Marino E. Leon, Farah K. Khalil, Barbara A. Centeno, Noel Clark, Valerie E. Stark, David L. Morse,  and Philip S. Low
132-132
Addendum  |  PDF  |  Supplementary Information  |  How to cite

Editorial

EXPOSOMES and GENES: The duo influencing CANCER initiation and progression

EXPOSOMES and GENES: The duo influencing CANCER initiation and progression

https://doi.org/10.18632/oncotarget.28696

Uzma Saqib, Katherine E. Ricks, Alexander G. Obukhov,  and Krishnan Hajela
133-135
PDF  |  How to cite  |  Press Release

Retraction

Retraction: MicroRNA-216a inhibits the metastasis of gastric cancer cells by targeting JAK2/STAT3-mediated EMT process

Retraction: MicroRNA-216a inhibits the metastasis of gastric cancer cells by targeting JAK2/STAT3-mediated EMT process

https://doi.org/10.18632/oncotarget.28702

Youmao Tao, Songbai Yang, Yuanyu Wu, Xuedong Fang, Yannan Wang, Yan Song,  and Tao Han
136-137
Retraction  |  PDF  |  How to cite

Editorial

COMETgazing - interesting insights, lessons for clinical practice and a call for more precision using the biomarkerSCOPE

COMETgazing - interesting insights, lessons for clinical practice and a call for more precision using the biomarkerSCOPE

https://doi.org/10.18632/oncotarget.28698

Mangesh A. Thorat
138-139
PDF  |  How to cite  |  Press Release

Precision Oncology

Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine: Bringing next-generation precision oncology to patients

Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine: Bringing next-generation precision oncology to patients

https://doi.org/10.18632/oncotarget.28703

Wafik S. El-Deiry, Catherine Bresson, Fanny Wunder, Benedito A. Carneiro, Don S. Dizon, Jeremy L. Warner, Stephanie L. Graff, Christopher G. Azzoli, Eric T. Wong, Liang Cheng, Sendurai A. Mani, Howard P. Safran, Casey Williams, Tobias Meissner, Benjamin Solomon, Eitan Rubin, Angel Porgador, Guy Berchem, Pierre Saintigny, Amir Onn, Jair Bar, Raanan Berger, Manon Gantenbein, Zhen Chen, Cristiano de Pádua Souza, Rui Manuel Vieira Reis, Marina Sekacheva, Andrés Cervantes, William L. Dahut, Christina M. Annunziata, Kerri Gober, Khaled M. Musallam, Humaid O. Al-Shamsi, Ibrahim Abu-Gheida, Ramon Salazar, Sewanti Limaye, Adel T. Aref, Roger R. Reddel, Mohammed Ussama Al Homsi, Abdul Rouf, Said Dermime, Jassim Al Suwaidi, Catalin Vlad, Rares Buiga, Amal Al Omari, Hikmat Abdel-Razeq, Luis F. Oñate-Ocaña, Finn Cilius Nielsen, Leah Graham, Jens Rueter, Anthony M. Joshua, Eugenia Girda, Steven Libutti, Gregory Riedlinger, Mohammed E. Salem, Carol J. Farhangfar, Ruben A. Mesa, Bishoy M. Faltas, Olivier Elemento, C.S. Pramesh, Manju Sengar, Satoru Aoyama, Sadakatsu Ikeda, Ioana Berindan-Neagoe, Himabindu Gaddipati, Mandar Kulkarni, Elisabeth Auzias, Maria Gerogianni, Nicolas Wolikow, Simon Istolainen, Pessie Schlafrig, Naftali Z. Frankel, Amanda R. Ferraro, Jim Palma, Alejandro Piris Gimenez, Alberto Hernando-Calvo, Enriqueta Felip, Apostolia M. Tsimberidou, Roy S. Herbst, Josep Tabernero, Richard L. Schilsky, Jia Liu, Yves Lussier, Jacques Raynaud, Gerald Batist, Shai Magidi,  and Razelle Kurzrock
140-162
Abstract  |  PDF  |  Full Text  |  How to cite  |  Press Release

Editorial

No disease left behind

No disease left behind

https://doi.org/10.18632/oncotarget.28700

Muzamil Arshad, Connor Lynch, Rohan R. Katipally, Sean P. Pitroda,  and Ralph R. Weichselbaum
163-166
PDF  |  How to cite  |  Press Release

Retraction

Retraction: Down-regulation of microRNA-320 suppresses cardiomyocyte apoptosis and protects against myocardial ischemia and reperfusion injury by targeting IGF-1

Retraction: Down-regulation of microRNA-320 suppresses cardiomyocyte apoptosis and protects against myocardial ischemia and reperfusion injury by targeting IGF-1

https://doi.org/10.18632/oncotarget.28704

Chun-Li Song, Bin Liu, Hong-Ying Diao, Yong-Feng Shi, Ji-Chang Zhang, Yang-Xue Li, Ning Liu, Yun-Peng Yu, Guan Wang, Jin-Peng Wang,  and Qian Li
167-167
Retraction  |  PDF  |  How to cite

Reviews

Signaling pathway dysregulation in breast cancer

Signaling pathway dysregulation in breast cancer

https://doi.org/10.18632/oncotarget.28701

Dinara Ryspayeva, Attila A. Seyhan, William J. MacDonald, Connor Purcell, Tyler J. Roady, Maryam Ghandali, Nataliia Verovkina, Wafik S. El-Deiry, Martin S. Taylor,  and Stephanie L. Graff
168-201
Abstract  |  PDF  |  Full Text  |  How to cite  |  Press Release

Research Papers

FGR Src family kinase causes signaling and phenotypic shift mimicking retinoic acid-induced differentiation of leukemic cells

FGR Src family kinase causes signaling and phenotypic shift mimicking retinoic acid-induced differentiation of leukemic cells

https://doi.org/10.18632/oncotarget.28705

Noor Kazim, Wang Peng, Jianbo Yue,  and Andrew Yen
202-218
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Retraction

Retraction: Silencing of BAG3 inhibits the epithelial-mesenchymal transition in human cervical cancer

Retraction: Silencing of BAG3 inhibits the epithelial-mesenchymal transition in human cervical cancer

https://doi.org/10.18632/oncotarget.28708

Fei Song, Geng Wang, Zhifang Ma, Yuebing Ma,  and Yingying Wang
219-219
Retraction  |  PDF  |  How to cite

Research Papers

NSD2-epigenomic reprogramming and maintenance of plasma cell phenotype in t(4;14) myeloma

NSD2-epigenomic reprogramming and maintenance of plasma cell phenotype in t(4;14) myeloma

https://doi.org/10.18632/oncotarget.28706

Andrea Gunnell, Scott T. Kimber, Richard Houlston,  and Martin Kaiser
220-229
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Research Papers

Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT

Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT

https://doi.org/10.18632/oncotarget.28707

Lanlan Zhou, Leiqing Zhang, Jun Zhang, Laura Jinxuan Wu, Shengliang Zhang, Andrew George, Marina Hahn, Howard P. Safran, Clark C. Chen, Attila A. Seyhan, Eric T. Wong,  and Wafik S. El-Deiry
230-248
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite


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